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ADCY8 ADCY8 ADCY1 ADCY1 ARAF ARAF RB1 RB1 GPSM3 GPSM3 SOS2 SOS2 KRAS KRAS LOC105819868 LOC105819868 SOS1 SOS1 ENSPCOP00000008641 ENSPCOP00000008641 E2F3 E2F3 MAPK3 MAPK3 PIK3R3 PIK3R3 MMP2 MMP2 SHC4 SHC4 LOC105812775 LOC105812775 PRKACB PRKACB HBEGF HBEGF NRAS NRAS RAF1 RAF1 MED1 MED1 JAG1 JAG1 NOTCH3 NOTCH3 NOTCH1 NOTCH1 DLL1 DLL1 ENSPCOP00000004497 ENSPCOP00000004497 JAG2 JAG2 ESR2 ESR2 DLL4 DLL4 NOTCH2 NOTCH2 ENSPCOP00000002686 ENSPCOP00000002686 ADCY6 ADCY6 MAPK9 MAPK9 CDK4 CDK4 MTOR MTOR ADCY2 ADCY2 MAP2K2 MAP2K2 PTRHD1 PTRHD1 E2F2 E2F2 FOS FOS LOC105805151 LOC105805151 TP53 TP53 SHC1 SHC1 GNAS GNAS RPS6KB1 RPS6KB1 PPP1R14B PPP1R14B BAD BAD MAPK13 MAPK13 PIK3CD PIK3CD CEP152 CEP152 MAPK1 MAPK1 ADCY5 ADCY5 CCND1 CCND1 CCDC170 CCDC170 NOTCH4 NOTCH4 AKT1 AKT1 PRKACA PRKACA AKT3 AKT3 MAPK8 MAPK8 ERBB2 ERBB2 CDKN1B CDKN1B SP1 SP1 CDKN2A CDKN2A PTK2 PTK2 NCOR1 NCOR1 BRAF BRAF ADCY9 ADCY9 ADCY7 ADCY7 ESR1 ESR1 MAPK10 MAPK10 IGF1R IGF1R BCL2 BCL2 ABCB11 ABCB11 HRAS HRAS BAX BAX SHC3 SHC3 IGF1 IGF1 AKT2 AKT2 SRC SRC PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR E2F1 E2F1 NCOA3 NCOA3 GRB2 GRB2 MAPK14 MAPK14 ADCY3 ADCY3 PIK3CB PIK3CB MAP2K1 MAP2K1 PIK3CA PIK3CA ENSPCOP00000015102 ENSPCOP00000015102 BIK BIK CDKN2C CDKN2C DLL3 DLL3 MAPK11 MAPK11 CARM1 CARM1 MAPK12 MAPK12 RPS6KB2 RPS6KB2 SHC2 SHC2 LOC105812777 LOC105812777 CSDE1 CSDE1 MMP9 MMP9 ADCY4 ADCY4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
RB1RB transcriptional corepressor 1. (787 aa)
GPSM3G protein signaling modulator 3. (160 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
KRASUncharacterized protein. (75 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
E2F3E2F transcription factor 3. (464 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
SHC4SHC adaptor protein 4. (630 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOTCH3Notch receptor 3. (2318 aa)
NOTCH1Notch receptor 1. (2420 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
ENSPCOP00000004497Uncharacterized protein. (280 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1101 aa)
ESR2Estrogen receptor 2. (471 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NOTCH2Notch receptor 2. (2471 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
ADCY2Adenylate cyclase 2. (904 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
E2F2E2F transcription factor 2. (435 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
LOC105805151Uncharacterized protein. (268 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
SHC1SHC adaptor protein 1. (582 aa)
GNASUncharacterized protein. (394 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PPP1R14BUncharacterized protein. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CEP152Centrosomal protein 152. (1655 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CCDC170Coiled-coil domain containing 170. (653 aa)
NOTCH4Notch receptor 4. (2000 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SP1Sp1 transcription factor. (788 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
NCOR1Nuclear receptor corepressor 1. (2432 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
ABCB11ATP binding cassette subfamily B member 11. (1288 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
SHC3SHC adaptor protein 3. (596 aa)
IGF1Insulin like growth factor 1. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SRCTyrosine-protein kinase. (543 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F1E2F transcription factor 1. (436 aa)
NCOA3Nuclear receptor coactivator. (1410 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
BIKBCL2 interacting killer. (152 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
DLL3Delta like canonical Notch ligand 3. (585 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (552 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
SHC2Uncharacterized protein. (578 aa)
LOC105812777Uncharacterized protein. (436 aa)
CSDE1Cold shock domain containing E1. (798 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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