(41 nodes) Mismatch repair network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	RPA2	Replication protein A2. (306 aa)
	POLD4	Uncharacterized protein. (107 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	MLH3	MutL homolog 3. (1456 aa)
	MEIOB	Meiosis specific with OB-fold. (289 aa)
	EXO1	Exonuclease 1. (835 aa)
	FBH1	F-box DNA helicase 1. (1056 aa)
	MLH1	MutL homolog 1. (757 aa)
	SASS6	SAS-6 centriolar assembly protein. (657 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1229 aa)
	ENSPCOP00000008190	AAA domain-containing protein. (331 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (174 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ENSPCOP00000008992	Uncharacterized protein. (248 aa)
	ATAD5	ATPase family AAA domain containing 5. (1646 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (504 aa)
	ISG20L2	Interferon stimulated exonuclease gene 20 like 2. (349 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
	YJU2	YJU2 splicing factor homolog. (325 aa)
	POLD1	DNA polymerase. (1125 aa)
	RFC1	Replication factor C subunit 1. (1113 aa)
	REXO4	REX4 homolog, 3'-5' exonuclease. (419 aa)
	POLD3	DNA polymerase delta 3, accessory subunit. (359 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	LIG1	DNA ligase. (916 aa)
	CABP5	Calcium binding protein 5. (165 aa)
	MSH4	MutS homolog 4. (834 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (719 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1091 aa)
	RFC4	Replication factor C subunit 4. (365 aa)
	RFC5	AAA domain-containing protein. (338 aa)
	AEN	Apoptosis enhancing nuclease. (325 aa)
	SSBP1	Single stranded DNA binding protein 1. (148 aa)
	LOC105824103	Uncharacterized protein. (430 aa)
	RPA3	Replication protein A3. (107 aa)
	MSH5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (836 aa)
	PRKRIP1	PRKR interacting protein 1. (187 aa)
	RAD17	RAD17 checkpoint clamp loader component. (475 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	ENSPCOP00000008190	ENSPCOP00000018109	ENSPCOP00000008190	Apoptosis enhancing nuclease.	AAA domain-containing protein.	0.499
AEN	FBH1	ENSPCOP00000018109	ENSPCOP00000003893	Apoptosis enhancing nuclease.	F-box DNA helicase 1.	0.733
AEN	PCNA	ENSPCOP00000018109	ENSPCOP00000008972	Apoptosis enhancing nuclease.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.912
AEN	RAD17	ENSPCOP00000018109	ENSPCOP00000023053	Apoptosis enhancing nuclease.	RAD17 checkpoint clamp loader component.	0.499
AEN	RFC2	ENSPCOP00000018109	ENSPCOP00000028762	Apoptosis enhancing nuclease.	Replication factor C subunit 2.	0.499
AEN	RFC3	ENSPCOP00000018109	ENSPCOP00000015964	Apoptosis enhancing nuclease.	Replication factor C subunit 3.	0.508
AEN	RFC4	ENSPCOP00000018109	ENSPCOP00000017227	Apoptosis enhancing nuclease.	Replication factor C subunit 4.	0.499
AEN	RFC5	ENSPCOP00000018109	ENSPCOP00000017256	Apoptosis enhancing nuclease.	AAA domain-containing protein.	0.499
AEN	SSBP1	ENSPCOP00000018109	ENSPCOP00000018234	Apoptosis enhancing nuclease.	Single stranded DNA binding protein 1.	0.502
ATAD5	ENSPCOP00000008190	ENSPCOP00000011601	ENSPCOP00000008190	ATPase family AAA domain containing 5.	AAA domain-containing protein.	0.986
ATAD5	EXO1	ENSPCOP00000011601	ENSPCOP00000001179	ATPase family AAA domain containing 5.	Exonuclease 1.	0.980
ATAD5	FBH1	ENSPCOP00000011601	ENSPCOP00000003893	ATPase family AAA domain containing 5.	F-box DNA helicase 1.	0.811
ATAD5	LIG1	ENSPCOP00000011601	ENSPCOP00000030243	ATPase family AAA domain containing 5.	DNA ligase.	0.894
ATAD5	MEIOB	ENSPCOP00000011601	ENSPCOP00000000779	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.882
ATAD5	MLH1	ENSPCOP00000011601	ENSPCOP00000004418	ATPase family AAA domain containing 5.	MutL homolog 1.	0.468
ATAD5	MSH2	ENSPCOP00000011601	ENSPCOP00000005815	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.565
ATAD5	MSH3	ENSPCOP00000011601	ENSPCOP00000017190	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.505
ATAD5	MSH6	ENSPCOP00000011601	ENSPCOP00000007510	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.603
ATAD5	PCNA	ENSPCOP00000011601	ENSPCOP00000008972	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.992
ATAD5	POLD1	ENSPCOP00000011601	ENSPCOP00000015021	ATPase family AAA domain containing 5.	DNA polymerase.	0.883