STRINGSTRING
ENSPCOP00000031755 ENSPCOP00000031755 IFNGR1 IFNGR1 IFNGR2 IFNGR2 LOC105827009 LOC105827009 LTBR LTBR ENSPCOP00000001263 ENSPCOP00000001263 MAP2K2 MAP2K2 MTOR MTOR PRKCG PRKCG TBCA TBCA ENSPCOP00000001884 ENSPCOP00000001884 ENSPCOP00000001921 ENSPCOP00000001921 CYBB CYBB SLC2A1 SLC2A1 ENSPCOP00000002148 ENSPCOP00000002148 ARSI ARSI EPO EPO PFKL PFKL PDK1 PDK1 ENSPCOP00000003318 ENSPCOP00000003318 ENSPCOP00000003811 ENSPCOP00000003811 ENSPCOP00000003860 ENSPCOP00000003860 HMOX1 HMOX1 ENSPCOP00000004635 ENSPCOP00000004635 HIF1A HIF1A ENSPCOP00000005309 ENSPCOP00000005309 CUL2 CUL2 LTF LTF ZAN ZAN HK1 HK1 EDN1 EDN1 ENSPCOP00000007021 ENSPCOP00000007021 CAMK2B CAMK2B GAPDH GAPDH EGLN3 EGLN3 ENSPCOP00000007946 ENSPCOP00000007946 PIK3R3 PIK3R3 NFKB1 NFKB1 IL6 IL6 MAPK3 MAPK3 TEK TEK ENSPCOP00000009588 ENSPCOP00000009588 NOS3 NOS3 ENSPCOP00000009899 ENSPCOP00000009899 ANGPT4 ANGPT4 ENO4 ENO4 RBX1 RBX1 SERPINE1 SERPINE1 INS INS ENO3 ENO3 PLCG2 PLCG2 EIF4E2 EIF4E2 LOC105817330 LOC105817330 ELOC ELOC ENSPCOP00000012589 ENSPCOP00000012589 HK2 HK2 RPS6KB2 RPS6KB2 ENSPCOP00000013858 ENSPCOP00000013858 LOC105813100 LOC105813100 PDHB PDHB VHL VHL EGF EGF ENSPCOP00000015361 ENSPCOP00000015361 PIK3CA PIK3CA MAP2K1 MAP2K1 EIF4E1B EIF4E1B PIK3CB PIK3CB FLT1 FLT1 PDHA1 PDHA1 ANGPT2 ANGPT2 ENSPCOP00000017736 ENSPCOP00000017736 EIF4EBP1 EIF4EBP1 EGFR EGFR PIK3R2 PIK3R2 PIK3R1 PIK3R1 LOC105826747 LOC105826747 AKT2 AKT2 IGF1 IGF1 EP300 EP300 ENSPCOP00000020173 ENSPCOP00000020173 MKNK2 MKNK2 IFNG IFNG BCL2 BCL2 FCGBP FCGBP CREBBP CREBBP ENSPCOP00000021134 ENSPCOP00000021134 LOC105809058 LOC105809058 ANGPT1 ANGPT1 CAMK2D CAMK2D IGF1R IGF1R PFKM PFKM CAMK2G CAMK2G ENSPCOP00000023046 ENSPCOP00000023046 LDHB LDHB ELOB ELOB HKDC1 HKDC1 VEGFA VEGFA NOS2 NOS2 PLCG1 PLCG1 ALDOA ALDOA CAMK2A CAMK2A INSR INSR ALDOC ALDOC ENO1 ENO1 HK3 HK3 ENSPCOP00000026233 ENSPCOP00000026233 ENSPCOP00000026464 ENSPCOP00000026464 TF TF TFRC TFRC EGLN1 EGLN1 EGLN2 EGLN2 CDKN1B CDKN1B TLR4 TLR4 ERBB2 ERBB2 ALDOB ALDOB AKT3 AKT3 MKNK1 MKNK1 AKT1 AKT1 IL6R IL6R PGK1 PGK1 TIMP1 TIMP1 PRKCA PRKCA PRKCB PRKCB MAPK1 MAPK1 PFKFB3 PFKFB3 LOC105809057 LOC105809057 STAT3 STAT3 PIK3CD PIK3CD NPPA NPPA RPS6KB1 RPS6KB1 PFKP PFKP ARNT ARNT ENO2 ENO2 RELA RELA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000031755Uncharacterized protein; Belongs to the LDH/MDH superfamily. (324 aa)
IFNGR1Interferon gamma receptor 1. (479 aa)
IFNGR2Interferon gamma receptor 2. (304 aa)
LOC10582700940S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (246 aa)
LTBRLymphotoxin beta receptor. (435 aa)
ENSPCOP00000001263Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (223 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
ENSPCOP00000001884Uncharacterized protein. (101 aa)
ENSPCOP00000001921L-lactate dehydrogenase. (273 aa)
CYBBCytochrome b-245 beta chain. (533 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (495 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
ARSIArylsulfatase family member I. (572 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
PFKLPhosphofructokinase, liver type. (687 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
ENSPCOP00000003318Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (114 aa)
ENSPCOP00000003811Glyceraldehyde-3-phosphate dehydrogenase. (336 aa)
ENSPCOP00000003860Ldh_1_C domain-containing protein. (87 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ENSPCOP00000004635L-lactate dehydrogenase. (233 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ENSPCOP00000005309Fe2OG dioxygenase domain-containing protein. (121 aa)
CUL2Cullin 2; Belongs to the cullin family. (630 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
ZANZonadhesin (gene/pseudogene). (2373 aa)
HK1Hexokinase 1. (881 aa)
EDN1Endothelin 1. (193 aa)
ENSPCOP00000007021Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (134 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (665 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
EGLN3Fe2OG dioxygenase domain-containing protein. (239 aa)
ENSPCOP00000007946Glyceraldehyde-3-phosphate dehydrogenase. (331 aa)
PIK3R3Uncharacterized protein. (454 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL6Uncharacterized protein. (211 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
NOS3Nitric oxide synthase 3. (994 aa)
ENSPCOP00000009899L-lactate dehydrogenase. (243 aa)
ANGPT4Angiopoietin 4. (499 aa)
ENO4Enolase 4. (620 aa)
RBX1Ring-box 1. (108 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ENO3Enolase 3. (434 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
LOC105817330L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
ENSPCOP00000012589Skp1_POZ domain-containing protein. (68 aa)
HK2Hexokinase 2. (841 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSPCOP00000013858Uncharacterized protein. (78 aa)
LOC105813100Gp_dh_N domain-containing protein. (253 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
VHLVon Hippel-Lindau tumor suppressor. (208 aa)
EGFEpidermal growth factor. (1132 aa)
ENSPCOP00000015361Uncharacterized protein. (129 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (387 aa)
ANGPT2Angiopoietin 2. (496 aa)
ENSPCOP00000017736Uncharacterized protein. (177 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PIK3R2Uncharacterized protein. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC105826747Gp_dh_N domain-containing protein. (313 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IGF1Insulin like growth factor 1. (208 aa)
EP300E1A binding protein p300. (2424 aa)
ENSPCOP00000020173Ldh_1_C domain-containing protein. (58 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (468 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
FCGBPUncharacterized protein. (1920 aa)
CREBBPCREB binding protein. (2449 aa)
ENSPCOP00000021134E1_dh domain-containing protein. (188 aa)
LOC105809058Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (344 aa)
ANGPT1Angiopoietin 1. (408 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (858 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (600 aa)
ENSPCOP00000023046Uncharacterized protein. (150 aa)
LDHBLdh_1_N domain-containing protein. (252 aa)
ELOBUbiquitin-like domain-containing protein. (118 aa)
HKDC1Hexokinase domain containing 1. (869 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
INSRInsulin receptor. (1192 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (378 aa)
ENO1Enolase 1. (434 aa)
HK3Hexokinase 3. (924 aa)
ENSPCOP00000026233Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (177 aa)
ENSPCOP00000026464Uncharacterized protein. (46 aa)
TFTransferrin; Belongs to the transferrin family. (697 aa)
TFRCTransferrin receptor. (760 aa)
EGLN1Uncharacterized protein. (427 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL6RInterleukin 6 receptor. (469 aa)
PGK1Phosphoglycerate kinase. (417 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (544 aa)
LOC105809057Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (344 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NPPANatriuretic peptide A. (153 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PFKPPhosphofructokinase, platelet. (751 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (748 aa)
ENO2Enolase 2. (434 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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