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| | CERS2 | Ceramide synthase 2. (411 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (220 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (365 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PRKCA | Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (501 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MAPK8 | Mitogen-activated protein kinase 8. (346 aa) |
| | S1PR1 | Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (447 aa) |
| | SGMS1 | Sphingomyelin synthase 1. (419 aa) |
| | ADAMTS19 | ADAM metallopeptidase with thrombospondin type 1 motif 19. (1215 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | ENSPCOP00000025645 | Uncharacterized protein. (162 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (295 aa) |
| | DEGS2 | Delta 4-desaturase, sphingolipid 2. (323 aa) |
| | ENSPCOP00000024796 | Uncharacterized protein. (442 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | SRMS | Tyrosine-protein kinase. (496 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (384 aa) |
| | ENSPCOP00000022276 | Peptidase M12B domain-containing protein. (545 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (473 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | GAB2 | GRB2 associated binding protein 2. (679 aa) |
| | BCL2 | BCL2 apoptosis regulator. (234 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (552 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (199 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | GNA12 | G protein subunit alpha 12. (380 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1150 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (598 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | IFITM10 | Interferon induced transmembrane protein 10. (189 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14. (340 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | TRADD | TNFRSF1A associated via death domain. (309 aa) |
| | NSMAF | Neutral sphingomyelinase activation associated factor. (925 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | CERS6 | Ceramide synthase 6. (392 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1. (377 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1317 aa) |
| | CERS3 | Ceramide synthase 3. (349 aa) |
| | PIK3CA | Phosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (410 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | FCER1A | Fc fragment of IgE receptor Ia. (238 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (443 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (455 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | ENSPCOP00000013862 | SER_THR_PHOSPHATASE domain-containing protein. (209 aa) |
| | CERS4 | Ceramide synthase 4. (396 aa) |
| | CSDE1 | Cold shock domain containing E1. (798 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (390 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | SPHK1 | Sphingosine kinase 1. (469 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | NOS3 | Nitric oxide synthase 3. (994 aa) |
| | KRAS | Uncharacterized protein. (75 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | ENSPCOP00000009588 | Uncharacterized protein. (316 aa) |
| | LOC105819868 | Protein kinase domain-containing protein. (302 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (961 aa) |
| | PIK3R3 | Uncharacterized protein. (454 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | ENSPCOP00000007999 | Uncharacterized protein. (107 aa) |
| | ROCK1 | Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (560 aa) |
| | GNAI1 | G protein subunit alpha i1. (354 aa) |
| | ENSPCOP00000007290 | Uncharacterized protein. (174 aa) |
| | PPP2R3B | Protein phosphatase 2 regulatory subunit B''beta. (479 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | PLCB1 | Phosphoinositide phospholipase C. (1010 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1504 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (558 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa) |
| | KNG1 | Uncharacterized protein. (391 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (441 aa) |
| | ENSPCOP00000002686 | CSD_1 domain-containing protein. (293 aa) |
| | ENSPCOP00000002561 | Uncharacterized protein. (546 aa) |
| | MS4A2 | Membrane spanning 4-domains A2. (241 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9. (417 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | CERS5 | Ceramide synthase 5. (392 aa) |
| | RAC3 | Rac family small GTPase 3. (205 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | PLD2 | Phospholipase. (932 aa) |
| | AADACL2 | Arylacetamide deacetylase like 2. (377 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa) |
| | ASAH2 | Neutral ceramidase. (726 aa) |
| | SPHK2 | Sphingosine kinase 2. (660 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (366 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa) |
| | ASAH1 | N-acylsphingosine amidohydrolase 1. (242 aa) |
| | PLD1 | Phospholipase. (1040 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa) |
| | TMIGD3 | Transmembrane and immunoglobulin domain containing 3; Belongs to the G-protein coupled receptor 1 family. (347 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (552 aa) |
