STRINGSTRING
EI24 EI24 CCNE1 CCNE1 ENSPCOP00000000292 ENSPCOP00000000292 RRM2B RRM2B FAS FAS PTEN PTEN SFN SFN CDK4 CDK4 ENSPCOP00000001819 ENSPCOP00000001819 PMAIP1 PMAIP1 RPRM RPRM CD82 CD82 RRM2 RRM2 CCNG2 CCNG2 ENSPCOP00000004684 ENSPCOP00000004684 GADD45B GADD45B CCND2 CCND2 SIAH2 SIAH2 LOC105809194 LOC105809194 SERPINB5 SERPINB5 LOC105812775 LOC105812775 CCNE2 CCNE2 ENSPCOP00000008097 ENSPCOP00000008097 CDK1 CDK1 TRMU TRMU FAM76B FAM76B SIAH1 SIAH1 CCNG1 CCNG1 SERPINE1 SERPINE1 SIVA1 SIVA1 ENSPCOP00000012261 ENSPCOP00000012261 SESN3 SESN3 FAM76A FAM76A C7orf31 C7orf31 TP73 TP73 HPS5 HPS5 LOC105812777 LOC105812777 LOC105817733 LOC105817733 AIFM2 AIFM2 CCNB1 CCNB1 ATR ATR TSC2 TSC2 BBC3 BBC3 CHEK1 CHEK1 ADGRB2 ADGRB2 APAF1 APAF1 ATM ATM CASP3 CASP3 SHISA5 SHISA5 IGF1 IGF1 BAX BAX GADD45G GADD45G DDB2 DDB2 BCL2L1 BCL2L1 BCL2 BCL2 PERP PERP ZMAT3 ZMAT3 CCND3 CCND3 LOC105822716 LOC105822716 CCNB2 CCNB2 GADD45A GADD45A SESN2 SESN2 CDK3 CDK3 PPM1D PPM1D ENSPCOP00000023228 ENSPCOP00000023228 SESN1 SESN1 ENSPCOP00000023440 ENSPCOP00000023440 CASP8 CASP8 GORAB GORAB MDM4 MDM4 THBS1 THBS1 ENSPCOP00000024796 ENSPCOP00000024796 RCHY1 RCHY1 CDKN2A CDKN2A STEAP3 STEAP3 CDK6 CDK6 CHEK2 CHEK2 ENSPCOP00000027105 ENSPCOP00000027105 CNTD2 CNTD2 LOC105807375 LOC105807375 GTSE1 GTSE1 MDM2 MDM2 PIDD1 PIDD1 ENSPCOP00000028627 ENSPCOP00000028627 CRYZ CRYZ CASP9 CASP9 CCND1 CCND1 CDK2 CDK2 TP53 TP53 IGFBP3 IGFBP3 LOC105815609 LOC105815609 BID BID
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EI24Uncharacterized protein. (252 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ENSPCOP00000000292Uncharacterized protein. (404 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
FASFas cell surface death receptor. (309 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ENSPCOP00000001819Uncharacterized protein. (406 aa)
PMAIP1Uncharacterized protein. (54 aa)
RPRMReprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
CD82Tetraspanin. (267 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (386 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
ENSPCOP00000004684Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
LOC105809194PKS_ER domain-containing protein. (179 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ENSPCOP00000008097Uncharacterized protein. (192 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
TRMUtRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (417 aa)
FAM76BFamily with sequence similarity 76 member B. (338 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (312 aa)
CCNG1Cyclin G1. (151 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
ENSPCOP00000012261Uncharacterized protein. (74 aa)
SESN3Sestrin 3. (495 aa)
FAM76AFamily with sequence similarity 76 member A. (341 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1129 aa)
LOC105812777Uncharacterized protein. (436 aa)
LOC105817733PKS_ER domain-containing protein. (318 aa)
AIFM2Apoptosis inducing factor mitochondria associated 2. (373 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
TSC2TSC complex subunit 2. (1814 aa)
BBC3BCL2 binding component 3. (260 aa)
CHEK1Checkpoint kinase 1. (454 aa)
ADGRB2Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1564 aa)
APAF1Apoptotic peptidase activating factor 1. (1204 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
SHISA5Shisa family member 5. (239 aa)
IGF1Insulin like growth factor 1. (208 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
ZMAT3Zinc finger matrin-type 3. (288 aa)
CCND3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
LOC105822716Uncharacterized protein. (334 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (399 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
SESN2Sestrin 2. (480 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
ENSPCOP00000023228Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
SESN1Sestrin 1. (551 aa)
ENSPCOP00000023440Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
GORABGolgin, RAB6 interacting. (369 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
THBS1Thrombospondin 1. (1185 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (231 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
CHEK2Checkpoint kinase 2. (571 aa)
ENSPCOP00000027105Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (292 aa)
LOC105807375Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GTSE1G2 and S-phase expressed 1. (726 aa)
MDM2Uncharacterized protein. (68 aa)
PIDD1P53-induced death domain protein 1. (915 aa)
ENSPCOP00000028627Cyclin_C domain-containing protein. (259 aa)
CRYZPKS_ER domain-containing protein. (330 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
IGFBP3Insulin like growth factor binding protein 3. (293 aa)
LOC105815609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (220 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.