STRINGSTRING
TAX1BP1 TAX1BP1 ULK1 ULK1 OPTN OPTN ENSPCOP00000001321 ENSPCOP00000001321 LOC105815466 LOC105815466 GABARAPL2 GABARAPL2 MAPK9 MAPK9 AGFG1 AGFG1 TFEB TFEB AGFG2 AGFG2 ENSPCOP00000002686 ENSPCOP00000002686 ENSPCOP00000002706 ENSPCOP00000002706 MFN2 MFN2 LOC105820322 LOC105820322 UBA52 UBA52 HIF1A HIF1A RAB7A RAB7A NRAS NRAS RHOT1 RHOT1 CFAP70 CFAP70 TBC1D15 TBC1D15 ATG5 ATG5 FUNDC2 FUNDC2 ATG9A ATG9A KRAS KRAS TBC1D17 TBC1D17 USP30 USP30 RRAS2 RRAS2 FUNDC1 FUNDC1 REM1 REM1 PGAM5 PGAM5 USP15 USP15 USP43 USP43 NPAS1 NPAS1 CSDE1 CSDE1 ENSPCOP00000012718 ENSPCOP00000012718 RRAS RRAS ENSPCOP00000013079 ENSPCOP00000013079 MFN1 MFN1 BNIP3 BNIP3 CSNK2B CSNK2B SQSTM1 SQSTM1 RAB7B RAB7B RASL11B RASL11B RPS27A RPS27A PRKN PRKN TBK1 TBK1 RHOT2 RHOT2 ATF4 ATF4 NPAS3 NPAS3 E2F1 E2F1 SRC SRC ENSPCOP00000018904 ENSPCOP00000018904 USP19 USP19 SPEN SPEN HRAS HRAS LY6G5B LY6G5B ENSPCOP00000019899 ENSPCOP00000019899 CALCOCO2 CALCOCO2 GABARAP GABARAP BCL2L1 BCL2L1 RIT2 RIT2 HIF3A HIF3A GEM GEM ENSPCOP00000021800 ENSPCOP00000021800 CITED2 CITED2 MAPK10 MAPK10 USP4 USP4 MRAS MRAS CSNK2A1 CSNK2A1 PDIK1L PDIK1L USP11 USP11 ENSPCOP00000023542 ENSPCOP00000023542 PINK1 PINK1 METTL17 METTL17 CSNK2A2 CSNK2A2 FOXO3 FOXO3 EIF2AK3 EIF2AK3 REM2 REM2 STK35 STK35 TOMM7 TOMM7 ENSPCOP00000026845 ENSPCOP00000026845 SP1 SP1 BNIP3L BNIP3L LOC105816759 LOC105816759 MITF MITF ENSPCOP00000028215 ENSPCOP00000028215 USP32 USP32 MAPK8 MAPK8 USP8 USP8 TFEC TFEC RIT1 RIT1 BECN1 BECN1 TFE3 TFE3 ATG9B ATG9B FIS1 FIS1 RRAD RRAD AMBRA1 AMBRA1 USP31 USP31 TP53 TP53 RELA RELA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAX1BP1Tax1 binding protein 1. (816 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1045 aa)
OPTNOptineurin. (568 aa)
ENSPCOP00000001321Uncharacterized protein. (49 aa)
LOC105815466Rab-GAP TBC domain-containing protein. (570 aa)
GABARAPL2Uncharacterized protein. (117 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
AGFG1ArfGAP with FG repeats 1. (497 aa)
TFEBTranscription factor EB. (525 aa)
AGFG2ArfGAP with FG repeats 2. (483 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ENSPCOP00000002706Uncharacterized protein. (237 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
LOC105820322Ubiquitin-like domain-containing protein. (77 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RAB7ARAB7A, member RAS oncogene family. (161 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RHOT1Uncharacterized protein. (752 aa)
CFAP70Cilia and flagella associated protein 70. (961 aa)
TBC1D15Rab-GAP TBC domain-containing protein. (654 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
FUNDC2FUN14 domain containing 2. (189 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
KRASUncharacterized protein. (75 aa)
TBC1D17TBC1 domain family member 17. (648 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
RRAS2RAS related 2. (201 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (289 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
USP43Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1122 aa)
NPAS1Neuronal PAS domain protein 1. (591 aa)
CSDE1Cold shock domain containing E1. (798 aa)
ENSPCOP00000012718Ubiquitin-like domain-containing protein. (74 aa)
RRASRAS related. (220 aa)
ENSPCOP00000013079Uncharacterized protein. (80 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (722 aa)
BNIP3Uncharacterized protein. (235 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
SQSTM1Sequestosome 1. (440 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
RASL11BRAS like family 11 member B. (247 aa)
RPS27ARibosomal protein S27a. (156 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
TBK1TANK binding kinase 1. (690 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (621 aa)
ATF4Activating transcription factor 4. (351 aa)
NPAS3Neuronal PAS domain protein 3. (843 aa)
E2F1E2F transcription factor 1. (436 aa)
SRCTyrosine-protein kinase. (543 aa)
ENSPCOP00000018904Ubiquitin-like domain-containing protein. (131 aa)
USP19Ubiquitin specific peptidase 19. (1385 aa)
SPENSpen family transcriptional repressor. (3629 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (201 aa)
ENSPCOP00000019899Miro domain-containing protein. (554 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (472 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
BCL2L1BCL2 like 1. (233 aa)
RIT2Ras like without CAAX 2. (164 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (669 aa)
GEMGTP binding protein overexpressed in skeletal muscle. (160 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (965 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (341 aa)
USP11Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (926 aa)
ENSPCOP00000023542Ubiquitin-like domain-containing protein. (112 aa)
PINK1PTEN induced kinase 1. (581 aa)
METTL17Methyltransferase like 17. (461 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (356 aa)
FOXO3Forkhead box O3. (672 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
STK35Serine/threonine kinase 35. (538 aa)
TOMM7Translocase of outer mitochondrial membrane 7. (55 aa)
ENSPCOP00000026845USP8_dimer domain-containing protein. (167 aa)
SP1Sp1 transcription factor. (788 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
LOC105816759Ubiquitin-like domain-containing protein. (156 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
ENSPCOP00000028215Uncharacterized protein. (117 aa)
USP32Uncharacterized protein; Belongs to the peptidase C19 family. (1542 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1068 aa)
TFECTranscription factor EC. (241 aa)
RIT1Ras like without CAAX 1. (219 aa)
BECN1Beclin 1. (448 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (576 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1270 aa)
USP31Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1345 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: medium (62%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.