STRINGSTRING
SORT1 SORT1 LIPA LIPA ATP6AP1 ATP6AP1 GNPTG GNPTG SLC17A1 SLC17A1 MFSD8 MFSD8 FUCA1 FUCA1 TSPAN11 TSPAN11 M6PR M6PR ENSPCOP00000006947 ENSPCOP00000006947 CLTB CLTB LGMN LGMN SLC17A5 SLC17A5 ARSJ ARSJ SUMF1 SUMF1 ATP6V1H ATP6V1H PNMA1 PNMA1 HEXA HEXA ACP5 ACP5 ATP6V0D1 ATP6V0D1 AP1B1 AP1B1 AP3S1 AP3S1 ATP6V0A1 ATP6V0A1 LAMP2 LAMP2 PSAP PSAP SLC17A4 SLC17A4 CATIP CATIP ENTPD4 ENTPD4 PPT1 PPT1 LAMP3 LAMP3 CLTC CLTC ENSPCOP00000003074 ENSPCOP00000003074 LIPM LIPM GLB1L2 GLB1L2 AP3B1 AP3B1 CTSH CTSH AP1S3 AP1S3 SULF1 SULF1 LITAF LITAF CD68 CD68 AP1G1 AP1G1 AP1S1 AP1S1 HYAL1 HYAL1 ENSPCOP00000000690 ENSPCOP00000000690 CTSC CTSC CTSD CTSD SLC17A3 SLC17A3 ASAH1 ASAH1 SPAM1 SPAM1 ZBED5 ZBED5 CTSO CTSO ACP6 ACP6 ATP6V0C ATP6V0C PLA2G15 PLA2G15 ENSPCOP00000029431 ENSPCOP00000029431 IDS IDS ERP44 ERP44 AP3M1 AP3M1 AP3S2 AP3S2 GGA1 GGA1 AGA AGA SCARB2 SCARB2 TSPAN4 TSPAN4 LDOC1 LDOC1 NAA80 NAA80 HGSNAT HGSNAT SMPDL3B SMPDL3B NAGLU NAGLU TBRG4 TBRG4 HYAL3 HYAL3 FUCA2 FUCA2 ATP6V0A2 ATP6V0A2 CTSV CTSV PNMA8A PNMA8A TMEM130 TMEM130 RTL8C RTL8C AP1M2 AP1M2 HYAL4 HYAL4 ACP4 ACP4 ARSG ARSG TSPAN3 TSPAN3 CTSZ CTSZ ABCB9 ABCB9 WDFY2 WDFY2 HYAL2 HYAL2 ARSB ARSB LAPTM4B LAPTM4B SMPD1 SMPD1 TPP1 TPP1 AP3D1 AP3D1 GALC GALC NPC2 NPC2 CTSA CTSA CLCN7 CLCN7 GLA GLA AP1S2 AP1S2 ARPIN ARPIN SNX14 SNX14 GLB1 GLB1 POLG POLG LAMP1 LAMP1 ATP6V0A4 ATP6V0A4 CLCN6 CLCN6 CTSK CTSK ENSPCOP00000020579 ENSPCOP00000020579 WDFY1 WDFY1 CLN5 CLN5 LIPN LIPN PPT2 PPT2 MCOLN1 MCOLN1 LOC105824234 LOC105824234 AP3M2 AP3M2 LOC105815021 LOC105815021 CTSS CTSS CTSB CTSB SGSH SGSH CTSE CTSE ABCA2 ABCA2 NPC1 NPC1 GLB1L GLB1L AP1G2 AP1G2 AP1M1 AP1M1 SLC17A2 SLC17A2 DNASE2B DNASE2B CD63 CD63 IFITM10 IFITM10 GM2A GM2A MATN3 MATN3 CTSL CTSL SLC11A1 SLC11A1 CD151 CD151 AP4B1 AP4B1 CLTCL1 CLTCL1 ENSPCOP00000016640 ENSPCOP00000016640 ACPP ACPP CLTA CLTA GAA GAA NAPSA NAPSA AP4E1 AP4E1 ENSPCOP00000015064 ENSPCOP00000015064 GGA2 GGA2 RTL9 RTL9 LAPTM4A LAPTM4A SDR39U1 SDR39U1 ENTPD7 ENTPD7 TSPAN9 TSPAN9 MAN2B1 MAN2B1 LITAFD LITAFD IGF2R IGF2R DNASE2 DNASE2 AP3B2 AP3B2 AP4M1 AP4M1 ATP6V0B ATP6V0B SLC11A2 SLC11A2 CLASRP CLASRP HEXB HEXB LAPTM5 LAPTM5 ENSPCOP00000012134 ENSPCOP00000012134 BOD1 BOD1 PEG10 PEG10 NAGPA NAGPA CD53 CD53 GALNS GALNS NEU1 NEU1 ENSPCOP00000010610 ENSPCOP00000010610 SULF2 SULF2 RTL3 RTL3 AP4S1 AP4S1 PNMA3 PNMA3 CLN3 CLN3 IDUA IDUA GIN1 GIN1 ARSA ARSA GNS GNS C9orf24 C9orf24 CTSG CTSG CDIP1 CDIP1 ATP6V0D2 ATP6V0D2 CTSW CTSW GNPTAB GNPTAB GBA GBA GGA3 GGA3 CD164 CD164 CPVL CPVL CTNS CTNS BOD1L1 BOD1L1 MANBA MANBA NAGA NAGA GUSB GUSB CTSF CTSF ACP2 ACP2 SLC25A1 SLC25A1 TCIRG1 TCIRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SORT1Sortilin. (831 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (458 aa)
GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma. (304 aa)
SLC17A1Solute carrier family 17 member 1. (467 aa)
MFSD8Major facilitator superfamily domain containing 8. (519 aa)
FUCA1Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (418 aa)
TSPAN11Tetraspanin. (253 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
ENSPCOP00000006947AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (139 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
LGMNLegumain. (433 aa)
SLC17A5Solute carrier family 17 member 5. (495 aa)
ARSJArylsulfatase family member J. (599 aa)
SUMF1Sulfatase modifying factor 1. (374 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (453 aa)
PNMA1PNMA family member 1. (353 aa)
HEXAUncharacterized protein. (436 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (389 aa)
AP1B1AP complex subunit beta. (949 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (756 aa)
LAMP2Lysosomal associated membrane protein 2. (414 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (523 aa)
SLC17A4Solute carrier family 17 member 4. (497 aa)
CATIPCiliogenesis associated TTC17 interacting protein. (387 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
PPT1Palmitoyl-protein thioesterase 1. (302 aa)
LAMP3Uncharacterized protein. (411 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
ENSPCOP00000003074Uncharacterized protein. (109 aa)
LIPMLipase; Belongs to the AB hydrolase superfamily. Lipase family. (422 aa)
GLB1L2Beta-galactosidase. (607 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (958 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (336 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
SULF1Sulfatase 1. (863 aa)
LITAFLipopolysaccharide induced TNF factor. (206 aa)
CD68CD68 molecule. (355 aa)
AP1G1AP-1 complex subunit gamma. (840 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
HYAL1Hyaluronidase. (435 aa)
ENSPCOP00000000690Clat_adaptor_s domain-containing protein. (174 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (463 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa)
SLC17A3Solute carrier family 17 member 3. (498 aa)
ASAH1N-acylsphingosine amidohydrolase 1. (242 aa)
SPAM1Hyaluronidase. (516 aa)
ZBED5Zinc finger BED-type containing 5. (693 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (316 aa)
ACP6Acid phosphatase 6, lysophosphatidic; Belongs to the histidine acid phosphatase family. (428 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
ENSPCOP00000029431Saposin B-type domain-containing protein. (129 aa)
IDSSulfatase domain-containing protein. (549 aa)
ERP44Endoplasmic reticulum protein 44. (380 aa)
AP3M1AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
AP3S2Clat_adaptor_s domain-containing protein. (204 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (646 aa)
AGAAspartylglucosaminidase. (346 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
TSPAN4Tetraspanin. (257 aa)
LDOC1LDOC1 regulator of NFKB signaling. (145 aa)
NAA80N(alpha)-acetyltransferase 80, NatH catalytic subunit. (286 aa)
HGSNATHeparan-alpha-glucosaminide N-acetyltransferase. (633 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (458 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (744 aa)
TBRG4Transforming growth factor beta regulator 4. (632 aa)
HYAL3Hyaluronidase. (417 aa)
FUCA2Alpha-L-fucosidase 2. (391 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
PNMA8APNMA family member 8A. (435 aa)
TMEM130Transmembrane protein 130. (423 aa)
RTL8CRetrotransposon Gag like 8C. (113 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (425 aa)
HYAL4Hyaluronidase. (481 aa)
ACP4Acid phosphatase 4; Belongs to the histidine acid phosphatase family. (425 aa)
ARSGArylsulfatase G. (525 aa)
TSPAN3Tetraspanin. (253 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
ABCB9ATP binding cassette subfamily B member 9. (766 aa)
WDFY2WD repeat and FYVE domain containing 2. (400 aa)
HYAL2Hyaluronidase. (473 aa)
ARSBArylsulfatase B. (531 aa)
LAPTM4BLysosomal protein transmembrane 4 beta. (314 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
TPP1Tripeptidyl peptidase 1. (563 aa)
AP3D1Adaptor related protein complex 3 subunit delta 1. (1208 aa)
GALCGalactosylceramidase. (642 aa)
NPC2NPC intracellular cholesterol transporter 2. (186 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (494 aa)
CLCN7Chloride voltage-gated channel 7. (864 aa)
GLAAlpha-galactosidase. (428 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
ARPINUncharacterized protein. (225 aa)
SNX14Sorting nexin 14. (946 aa)
GLB1Beta-galactosidase. (640 aa)
POLGDNA polymerase gamma, catalytic subunit. (1224 aa)
LAMP1Lysosomal associated membrane protein 1. (384 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
CLCN6Chloride voltage-gated channel 6; Belongs to the chloride channel (TC 2.A.49) family. (929 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
ENSPCOP00000020579Uncharacterized protein. (737 aa)
WDFY1Uncharacterized protein. (400 aa)
CLN5Uncharacterized protein. (389 aa)
LIPNLipase; Belongs to the AB hydrolase superfamily. Lipase family. (398 aa)
PPT2Palmitoyl-protein thioesterase 2. (308 aa)
MCOLN1Mucolipin 1. (569 aa)
LOC105824234Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
LOC105815021Uncharacterized protein. (567 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
SGSHN-sulfoglucosamine sulfohydrolase. (502 aa)
CTSECathepsin E; Belongs to the peptidase A1 family. (396 aa)
ABCA2ATP binding cassette subfamily A member 2. (2452 aa)
NPC1NPC intracellular cholesterol transporter 1. (1213 aa)
GLB1LGalactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (651 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
SLC17A2Solute carrier family 17 member 2. (478 aa)
DNASE2BDeoxyribonuclease 2 beta. (364 aa)
CD63Tetraspanin. (237 aa)
IFITM10Interferon induced transmembrane protein 10. (189 aa)
GM2AGM2 ganglioside activator. (196 aa)
MATN3Matrilin 3. (488 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
SLC11A1Solute carrier family 11 member 1. (546 aa)
CD151Tetraspanin. (253 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1426 aa)
ENSPCOP00000016640AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (178 aa)
ACPPAcid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (418 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (957 aa)
NAPSANapsin A aspartic peptidase; Belongs to the peptidase A1 family. (431 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (952 aa)
ENSPCOP00000015064Uncharacterized protein. (160 aa)
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (586 aa)
RTL9Retrotransposon Gag like 9. (1328 aa)
LAPTM4ALysosomal protein transmembrane 4 alpha. (233 aa)
SDR39U1Short chain dehydrogenase/reductase family 39U member 1. (294 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa)
TSPAN9Tetraspanin. (330 aa)
MAN2B1Alpha-mannosidase. (1010 aa)
LITAFDLITAF domain containing. (72 aa)
IGF2RInsulin like growth factor 2 receptor. (2496 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (362 aa)
AP3B2AP-3 complex subunit beta. (1104 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (291 aa)
SLC11A2Uncharacterized protein. (590 aa)
CLASRPCLK4 associating serine/arginine rich protein. (678 aa)
HEXBBeta-hexosaminidase. (526 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
ENSPCOP00000012134Glyco_hydro_35 domain-containing protein. (292 aa)
BOD1Uncharacterized protein. (199 aa)
PEG10CCHC-type domain-containing protein. (790 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (512 aa)
CD53Tetraspanin. (219 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (517 aa)
NEU1Neuraminidase 1. (416 aa)
ENSPCOP00000010610Uncharacterized protein. (82 aa)
SULF2Sulfatase 2. (850 aa)
RTL3Retrotransposon Gag like 3. (478 aa)
AP4S1Adaptor related protein complex 4 subunit sigma 1. (144 aa)
PNMA3PNMA family member 3. (455 aa)
CLN3Battenin. (438 aa)
IDUAIduronidase alpha-L-. (521 aa)
GIN1Gypsy retrotransposon integrase 1. (522 aa)
ARSAArylsulfatase A. (423 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (533 aa)
C9orf24Chromosome 9 open reading frame 24. (260 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (246 aa)
CDIP1Cell death inducing p53 target 1. (208 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (374 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1255 aa)
GBAGlucosylceramidase. (529 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (722 aa)
CD164CD164 molecule. (172 aa)
CPVLCarboxypeptidase vitellogenic like; Belongs to the peptidase S10 family. (462 aa)
CTNSCystinosin, lysosomal cystine transporter. (387 aa)
BOD1L1Biorientation of chromosomes in cell division 1 like 1. (3018 aa)
MANBAMannosidase beta. (877 aa)
NAGAAlpha-galactosidase. (411 aa)
GUSBBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (650 aa)
CTSFCathepsin F; Belongs to the peptidase C1 family. (482 aa)
ACP2Acid phosphatase 2, lysosomal; Belongs to the histidine acid phosphatase family. (423 aa)
SLC25A1Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (223 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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