STRINGSTRING
CAMKK2 CAMKK2 ENSPCOP00000002148 ENSPCOP00000002148 FBP2 FBP2 TSC1 TSC1 MTOR MTOR PPP2R5E PPP2R5E ELAVL1 ELAVL1 PFKFB2 PFKFB2 ULK1 ULK1 ENSPCOP00000000328 ENSPCOP00000000328 PPP2R5C PPP2R5C CPT1A CPT1A SCD SCD ENSPCOP00000028657 ENSPCOP00000028657 PPP2R5B PPP2R5B GYS2 GYS2 AKT1 AKT1 G6PC G6PC CCND1 CCND1 PFKFB3 PFKFB3 PIK3CD PIK3CD PRKAA2 PRKAA2 RHEBL1 RHEBL1 CCNA1 CCNA1 HNF4A HNF4A PRKAG2 PRKAG2 RAB10 RAB10 GYS1 GYS1 SIRT1 SIRT1 ADRA1A ADRA1A PFKP PFKP RPS6KB1 RPS6KB1 PCK1 PCK1 PCK2 PCK2 ACACB ACACB CREB3L1 CREB3L1 CREB3 CREB3 INSR INSR PPP2CA PPP2CA SCD5 SCD5 FOXO3 FOXO3 SREBF1 SREBF1 PRKAA1 PRKAA1 PPP2R5A PPP2R5A EEF2K EEF2K LIPE LIPE RAB8A RAB8A EEF2 EEF2 PPP2R2A PPP2R2A CREB5 CREB5 PFKM PFKM IGF1R IGF1R PPARGC1A PPARGC1A PPP2R1B PPP2R1B CAB39L CAB39L IRS2 IRS2 CRTC2 CRTC2 G6PC2 G6PC2 IGF1 IGF1 AKT2 AKT2 CREB1 CREB1 PPP2R3A PPP2R3A PIK3R1 PIK3R1 PPP2R5D PPP2R5D PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 PRKAG3 PRKAG3 RAB2A RAB2A PIK3CB PIK3CB PFKFB1 PFKFB1 TSC2 TSC2 CREB3L4 CREB3L4 G6PC3 G6PC3 PIK3CA PIK3CA ADIPOR1 ADIPOR1 PPP2R3C PPP2R3C PPP2R2D PPP2R2D ACACA ACACA ENSPCOP00000013862 ENSPCOP00000013862 RPS6KB2 RPS6KB2 SLC2A4 SLC2A4 ADIPOQ ADIPOQ CPT1C CPT1C CREB3L3 CREB3L3 FOXO1 FOXO1 RAB14 RAB14 PPARG PPARG LOC105822391 LOC105822391 STRADB STRADB GAREM2 GAREM2 CPT1B CPT1B LEPR LEPR INS INS TBC1D1 TBC1D1 CD36 CD36 HMGCR HMGCR FASN FASN RPTOR RPTOR STRADA STRADA ADIPOR2 ADIPOR2 RHEB RHEB PFKFB4 PFKFB4 CREB3L2 CREB3L2 PIK3R3 PIK3R3 FBP1 FBP1 PPP2R2C PPP2R2C AKT3 AKT3 ENSPCOP00000007709 ENSPCOP00000007709 CFTR CFTR PRKAB2 PRKAB2 PPP2R3B PPP2R3B PPP2CB PPP2CB MLYCD MLYCD CCNA2 CCNA2 PRKAG1 PRKAG1 MAP3K7 MAP3K7 LEP LEP ENSPCOP00000005894 ENSPCOP00000005894 CAB39 CAB39 PDPK1 PDPK1 PPP2R2B PPP2R2B STK11 STK11 PPP2R1A PPP2R1A AKT1S1 AKT1S1 PRKAB1 PRKAB1 PFKL PFKL ENSPCOP00000002561 ENSPCOP00000002561
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
TSC1TSC complex subunit 1. (1164 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (507 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1045 aa)
ENSPCOP00000000328Uncharacterized protein. (67 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (697 aa)
SCDStearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
ENSPCOP00000028657Uncharacterized protein. (79 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (501 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (450 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (544 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
RHEBL1RHEB like 1. (183 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (442 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (540 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (738 aa)
SIRT1Sirtuin 1. (743 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
PFKPPhosphofructokinase, platelet. (751 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ACACBAcetyl-CoA carboxylase beta. (2172 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
INSRInsulin receptor. (1192 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (305 aa)
FOXO3Forkhead box O3. (672 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1180 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
LIPELipase E, hormone sensitive type. (1052 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (384 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (858 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
PPARGC1APPARG coactivator 1 alpha. (809 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (552 aa)
CAB39LCalcium binding protein 39 like. (337 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
CRTC2CREB regulated transcription coactivator 2. (686 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
IGF1Insulin like growth factor 1. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (598 aa)
PIK3R2Uncharacterized protein. (726 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
RAB2ARAB2A, member RAS oncogene family. (212 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
TSC2TSC complex subunit 2. (1814 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (410 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
ACACAAcetyl-CoA carboxylase alpha. (2347 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (802 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
FOXO1Forkhead box O1. (656 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (502 aa)
LOC105822391FBPase domain-containing protein; Belongs to the FBPase class 1 family. (278 aa)
STRADBSTE20 related adaptor beta. (377 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (875 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
LEPRLeptin receptor. (1055 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TBC1D1TBC1 domain family member 1. (1172 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
FASNFatty acid synthase. (2506 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1281 aa)
STRADASTE20 related adaptor alpha. (419 aa)
ADIPOR2Adiponectin receptor 2. (325 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (508 aa)
PIK3R3Uncharacterized protein. (454 aa)
FBP1FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSPCOP00000007709Uncharacterized protein. (186 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1426 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (479 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
MLYCDMalonyl-CoA decarboxylase. (498 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSPCOP00000005894Uncharacterized protein. (192 aa)
CAB39Calcium binding protein 39. (341 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
AKT1S1AKT1 substrate 1. (274 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PFKLPhosphofructokinase, liver type. (687 aa)
ENSPCOP00000002561Uncharacterized protein. (546 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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