STRINGSTRING
ITPR1 ITPR1 RBBP4 RBBP4 PPP3CB PPP3CB PKD1L1 PKD1L1 MAP2K6 MAP2K6 CCNA1 CCNA1 RHEBL1 RHEBL1 CDKN2A CDKN2A CDK6 CDK6 ENSPCOP00000026433 ENSPCOP00000026433 CHEK2 CHEK2 CNTD2 CNTD2 PPP1CA PPP1CA CAPN12 CAPN12 GATA6 GATA6 GATA4 GATA4 SIRT1 SIRT1 HIPK1 HIPK1 MDM2 MDM2 AKT3 AKT3 ENSPCOP00000028627 ENSPCOP00000028627 E2F5 E2F5 AKT1 AKT1 CDKN2B CDKN2B CCND1 CCND1 LOC105817290 LOC105817290 MAPK1 MAPK1 VDAC3 VDAC3 SLC25A4 SLC25A4 PIK3CD PIK3CD MAPK13 MAPK13 CAPN11 CAPN11 GADD45G GADD45G HRAS HRAS VDAC1 VDAC1 RAD9B RAD9B AKT2 AKT2 RAD9A RAD9A TGFBR1 TGFBR1 ITPR3 ITPR3 MCUB MCUB PIK3R1 PIK3R1 PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 E2F1 E2F1 BTRC BTRC CALML4 CALML4 ATM ATM MAPK14 MAPK14 CAPN8 CAPN8 CHEK1 CHEK1 MR1 MR1 SLC25A5 SLC25A5 E2F4 E2F4 RBL1 RBL1 PIK3CB PIK3CB LIN37 LIN37 RBL2 RBL2 TSC2 TSC2 ATR ATR MAP2K1 MAP2K1 PIK3CA PIK3CA CCNB1 CCNB1 NFATC2 NFATC2 PVALEF PVALEF SQSTM1 SQSTM1 MAPK11 MAPK11 LOC105817910 LOC105817910 HUS1B HUS1B MAPK12 MAPK12 CALM2 CALM2 LOC105812777 LOC105812777 ENSPCOP00000013454 ENSPCOP00000013454 CACNA1D CACNA1D IL1A IL1A PPP3CC PPP3CC RRAS RRAS CSDE1 CSDE1 HIPK3 HIPK3 FOXO1 FOXO1 CAPN3 CAPN3 REM1 REM1 CALM3 CALM3 PPP1CB PPP1CB LOC105810224 LOC105810224 FOXM1 FOXM1 CCNB3 CCNB3 FBXW11 FBXW11 RB1 RB1 SERPINE1 SERPINE1 RRAS2 RRAS2 ENSPCOP00000010764 ENSPCOP00000010764 TRAF3IP2 TRAF3IP2 CALM1 CALM1 LIN54 LIN54 KRAS KRAS EFCAB3 EFCAB3 LOC105819868 LOC105819868 RHEB RHEB NFATC4 NFATC4 HUS1 HUS1 MRE11 MRE11 E2F3 E2F3 CDK1 CDK1 CAPN1 CAPN1 MAPK3 MAPK3 ZFP36L2 ZFP36L2 IL6 IL6 NFKB1 NFKB1 PIK3R3 PIK3R3 ENSPCOP00000007681 ENSPCOP00000007681 CCNE2 CCNE2 LOC105812775 LOC105812775 TGFB3 TGFB3 ENSPCOP00000006829 ENSPCOP00000006829 CDC25A CDC25A TPRG1L TPRG1L MAPKAPK2 MAPKAPK2 CCNA2 CCNA2 ENSPCOP00000005894 ENSPCOP00000005894 PPP3CA PPP3CA NRAS NRAS RAF1 RAF1 ENSPCOP00000005162 ENSPCOP00000005162 CCND2 CCND2 GADD45B GADD45B ENSPCOP00000004671 ENSPCOP00000004671 VDAC2 VDAC2 ENSPCOP00000003978 ENSPCOP00000003978 ITPR2 ITPR2 HIPK2 HIPK2 MYC MYC ENSPCOP00000002686 ENSPCOP00000002686 LIN9 LIN9 GATA5 GATA5 ENSPCOP00000002211 ENSPCOP00000002211 ENSPCOP00000002207 ENSPCOP00000002207 ENSPCOP00000002148 ENSPCOP00000002148 TSC1 TSC1 CDK4 CDK4 MTOR MTOR NFATC3 NFATC3 LOC105817288 LOC105817288 PTEN PTEN MAP2K2 MAP2K2 TGFBR2 TGFBR2 TGFB2 TGFB2 NFATC1 NFATC1 E2F2 E2F2 LIN52 LIN52 NBN NBN SMAD2 SMAD2 RAD1 RAD1 ENSPCOP00000000308 ENSPCOP00000000308 ENSPCOP00000000307 ENSPCOP00000000307 CCNE1 CCNE1 RRAD RRAD TRPM7 TRPM7 TRPV4 TRPV4 CDK2 CDK2 MAP2K3 MAP2K3 MYBL2 MYBL2 TP53 TP53 ETS1 ETS1 IGFBP3 IGFBP3 CAPN9 CAPN9 AZGP1 AZGP1 RELA RELA CAPN14 CAPN14 PPP3R1 PPP3R1 PPID PPID ZFP36L1 ZFP36L1 CAPN2 CAPN2 GEM GEM CCND3 CCND3 TESMIN TESMIN PPP1CC PPP1CC SMAD3 SMAD3 SLC25A6 SLC25A6 CCNB2 CCNB2 GADD45A GADD45A ENSPCOP00000022360 ENSPCOP00000022360 CDK3 CDK3 MRAS MRAS RBBP7 RBBP7 TGFB1 TGFB1 CRYBB3 CRYBB3 HIPK4 HIPK4 TPRG1 TPRG1 LOC105810171 LOC105810171 ENSPCOP00000023872 ENSPCOP00000023872 SLC25A31 SLC25A31 ENSPCOP00000024532 ENSPCOP00000024532 MCU MCU CXCL8 CXCL8 ENSPCOP00000024796 ENSPCOP00000024796 FOXO3 FOXO3 RASSF5 RASSF5 LOC105817846 LOC105817846
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
PKD1L1Polycystin 1 like 1, transient receptor potential channel interacting. (2710 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (442 aa)
RHEBL1RHEB like 1. (183 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
ENSPCOP00000026433Uncharacterized protein. (628 aa)
CHEK2Checkpoint kinase 2. (571 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (292 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CAPN12Calpain 12; Belongs to the peptidase C2 family. (691 aa)
GATA6GATA binding protein 6. (593 aa)
GATA4GATA binding protein 4. (445 aa)
SIRT1Sirtuin 1. (743 aa)
HIPK1Homeodomain interacting protein kinase 1. (1131 aa)
MDM2Uncharacterized protein. (68 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSPCOP00000028627Cyclin_C domain-containing protein. (259 aa)
E2F5E2F transcription factor 5. (312 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
LOC105817290Ig-like domain-containing protein; Belongs to the MHC class I family. (464 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CAPN11Calpain 11; Belongs to the peptidase C2 family. (733 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
VDAC1Uncharacterized protein. (283 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (416 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
MCUBMitochondrial calcium uniporter dominant negative beta subunit. (229 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
E2F1E2F transcription factor 1. (436 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (609 aa)
CALML4Calmodulin like 4. (178 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
CAPN8Calpain 8; Belongs to the peptidase C2 family. (703 aa)
CHEK1Checkpoint kinase 1. (454 aa)
MR1Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (337 aa)
SLC25A5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
E2F4E2F transcription factor 4. (408 aa)
RBL1RB transcriptional corepressor like 1. (935 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
LIN37Lin-37 DREAM MuvB core complex component. (251 aa)
RBL2RB transcriptional corepressor like 2. (925 aa)
TSC2TSC complex subunit 2. (1814 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
SQSTM1Sequestosome 1. (440 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
LOC105817910Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (253 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
LOC105812777Uncharacterized protein. (436 aa)
ENSPCOP00000013454Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
RRASRAS related. (220 aa)
CSDE1Cold shock domain containing E1. (798 aa)
HIPK3Homeodomain interacting protein kinase 3. (1129 aa)
FOXO1Forkhead box O1. (656 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (282 aa)
LOC105810224Tankyrase_bdg_C domain-containing protein. (390 aa)
FOXM1Forkhead box M1. (763 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1307 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
RB1RB transcriptional corepressor 1. (787 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
RRAS2RAS related 2. (201 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
TRAF3IP2TRAF3 interacting protein 2. (562 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
LIN54Lin-54 DREAM MuvB core complex component. (720 aa)
KRASUncharacterized protein. (75 aa)
EFCAB3Uncharacterized protein. (185 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
NFATC4Nuclear factor of activated T cells 4. (953 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
E2F3E2F transcription factor 3. (464 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (714 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ZFP36L2ZFP36 ring finger protein like 2. (493 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
PIK3R3Uncharacterized protein. (454 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSPCOP00000006829Uncharacterized protein. (252 aa)
CDC25ACell division cycle 25A. (527 aa)
TPRG1LTumor protein p63 regulated 1 like. (272 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
ENSPCOP00000005894Uncharacterized protein. (192 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ENSPCOP00000005162WD_REPEATS_REGION domain-containing protein. (355 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ENSPCOP00000004671Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (276 aa)
VDAC2Voltage dependent anion channel 2. (309 aa)
ENSPCOP00000003978Uncharacterized protein. (482 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
LIN9Lin-9 DREAM MuvB core complex component. (593 aa)
GATA5GATA binding protein 5. (394 aa)
ENSPCOP00000002211Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
TSC1TSC complex subunit 1. (1164 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
LOC105817288Ig-like domain-containing protein; Belongs to the MHC class I family. (371 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NFATC1Nuclear factor of activated T cells 1. (945 aa)
E2F2E2F transcription factor 2. (435 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
NBNNbs1_C domain-containing protein. (429 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
RAD1Uncharacterized protein. (282 aa)
ENSPCOP00000000308Uncharacterized protein. (257 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1683 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MYBL2MYB proto-oncogene like 2. (699 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
IGFBP3Insulin like growth factor binding protein 3. (293 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (690 aa)
AZGP1Alpha-2-glycoprotein 1, zinc-binding; Belongs to the MHC class I family. (312 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (676 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPIDPeptidylprolyl isomerase D. (305 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
GEMGTP binding protein overexpressed in skeletal muscle. (160 aa)
CCND3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
TESMINTestis expressed metallothionein like protein. (484 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (399 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ENSPCOP00000022360FHA domain-containing protein. (60 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
HIPK4Homeodomain interacting protein kinase 4; Belongs to the protein kinase superfamily. (397 aa)
TPRG1Tumor protein p63 regulated 1. (279 aa)
LOC105810171Uncharacterized protein. (1584 aa)
ENSPCOP00000023872Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (116 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (270 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
MCUMitochondrial calcium uniporter. (350 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
FOXO3Forkhead box O3. (672 aa)
RASSF5Ras association domain family member 5. (318 aa)
LOC105817846Ig-like domain-containing protein; Belongs to the MHC class I family. (373 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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