STRINGSTRING
EPHB6 EPHB6 EFNB2 EFNB2 SEMA4B SEMA4B ARHGEF12 ARHGEF12 RASA1 RASA1 EPHB2 EPHB2 NCK1 NCK1 MYL9 MYL9 PRKCZ PRKCZ RAC3 RAC3 NFATC3 NFATC3 ENSPCOP00000001901 ENSPCOP00000001901 ENSPCOP00000002125 ENSPCOP00000002125 ARSI ARSI PLXNA1 PLXNA1 LOC105805812 LOC105805812 ENSPCOP00000002686 ENSPCOP00000002686 ITGB1 ITGB1 NCK2 NCK2 ENSPCOP00000002927 ENSPCOP00000002927 SEMA6B SEMA6B PDK1 PDK1 L1CAM L1CAM BOC BOC BMP7 BMP7 TRPC1 TRPC1 ENAH ENAH CFL2 CFL2 PLXNA2 PLXNA2 PAK5 PAK5 ROBO1 ROBO1 ENSPCOP00000004990 ENSPCOP00000004990 RAF1 RAF1 NTN3 NTN3 NRAS NRAS PPP3CA PPP3CA ENSPCOP00000005631 ENSPCOP00000005631 NTN4 NTN4 PAK4 PAK4 NTN1 NTN1 RHOA RHOA CXCL12 CXCL12 UNC5B UNC5B LDAH LDAH SEMA4C SEMA4C SEMA3A SEMA3A SEMA3B SEMA3B SEMA5B SEMA5B ENSPCOP00000007290 ENSPCOP00000007290 CAMK2B CAMK2B GNAI1 GNAI1 PAK1 PAK1 SEMA4F SEMA4F SEMA3G SEMA3G WNT5A WNT5A ROCK1 ROCK1 PARD6A PARD6A PIK3R3 PIK3R3 MAPK3 MAPK3 RGS3 RGS3 ENSPCOP00000008391 ENSPCOP00000008391 ENSPCOP00000008407 ENSPCOP00000008407 FYN FYN DPYSL5 DPYSL5 SSH3 SSH3 SRGAP3 SRGAP3 PLXNA3 PLXNA3 SSH2 SSH2 NFATC4 NFATC4 LOC105822409 LOC105822409 ENSPCOP00000009588 ENSPCOP00000009588 RAC2 RAC2 KRAS KRAS MYL5 MYL5 ENSPCOP00000009764 ENSPCOP00000009764 FZD3 FZD3 SEMA3E SEMA3E EPHA2 EPHA2 SEMA6D SEMA6D UNC5D UNC5D ENSPCOP00000010769 ENSPCOP00000010769 PLXNB1 PLXNB1 RHOC RHOC ENSPCOP00000011171 ENSPCOP00000011171 SEMA4D SEMA4D TRPC5 TRPC5 NEO1 NEO1 TRPC4 TRPC4 ROCK2 ROCK2 PLCG2 PLCG2 PARD3 PARD3 TRPC7 TRPC7 SSH1 SSH1 EPHA4 EPHA4 CSDE1 CSDE1 RRAS RRAS RYK RYK SLIT2 SLIT2 SEMA5A SEMA5A PPP3CC PPP3CC ROBO2 ROBO2 MYL12A MYL12A ENSPCOP00000013931 ENSPCOP00000013931 EFNA2 EFNA2 EPHB1 EPHB1 ILK ILK SLIT3 SLIT3 BMPR1B BMPR1B BMPR2 BMPR2 PLXNA4 PLXNA4 EFNA1 EFNA1 NFATC2 NFATC2 EFNA4 EFNA4 PIK3CA PIK3CA LRRC4 LRRC4 EFNB3 EFNB3 PIK3CB PIK3CB RGMA RGMA LIMK1 LIMK1 NRP1 NRP1 PAK6 PAK6 RAC1 RAC1 EPHA10 EPHA10 EPHA8 EPHA8 ENSPCOP00000018033 ENSPCOP00000018033 GDF7 GDF7 SEMA7A SEMA7A PIK3R2 PIK3R2 PIK3R1 PIK3R1 SRC SRC EPHB3 EPHB3 RND1 RND1 SEMA4A SEMA4A HRAS HRAS ABLIM3 ABLIM3 CFL1 CFL1 ROBO3 ROBO3 EPHB4 EPHB4 SRGAP1 SRGAP1 TRPC3 TRPC3 PPP3R1 PPP3R1 PAK2 PAK2 ABLIM1 ABLIM1 WNT4 WNT4 CAMK2D CAMK2D MET MET ENSPCOP00000022056 ENSPCOP00000022056 ENSPCOP00000022111 ENSPCOP00000022111 CDC42 CDC42 CAMK2G CAMK2G SEMA4G SEMA4G PTCH1 PTCH1 TRPC6 TRPC6 PAK3 PAK3 GSK3B GSK3B EPHA3 EPHA3 SEMA6C SEMA6C PLXNB2 PLXNB2 CXCR4 CXCR4 SRMS SRMS PLXNB3 PLXNB3 PLCG1 PLCG1 ENSPCOP00000024978 ENSPCOP00000024978 ADAM15 ADAM15 UNC5A UNC5A CAMK2A CAMK2A PPP3CB PPP3CB ENSPCOP00000025645 ENSPCOP00000025645 PTK2 PTK2 NTNG2 NTNG2 EPHA1 EPHA1 CDK5 CDK5 NTNG1 NTNG1 LIMK2 LIMK2 ENSPCOP00000028080 ENSPCOP00000028080 SMO SMO SEMA3F SEMA3F NGEF NGEF PLXNC1 PLXNC1 PTPN11 PTPN11 PRKCA PRKCA SEMA6A SEMA6A MAPK1 MAPK1 EFNA5 EFNA5 LOC105817025 LOC105817025 ABLIM2 ABLIM2 SRGAP2 SRGAP2 DPYSL2 DPYSL2 GNAI2 GNAI2 PIK3CD PIK3CD UNC5C UNC5C ENSPCOP00000030916 ENSPCOP00000030916 MYL12B MYL12B FES FES WNT5B WNT5B RHOD RHOD EFNA3 EFNA3 SLIT1 SLIT1 EFNB1 EFNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHB6EPH receptor B6. (1019 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (828 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1496 aa)
RASA1RAS p21 protein activator 1. (623 aa)
EPHB2EPH receptor B2. (1039 aa)
NCK1Cytoplasmic protein. (377 aa)
MYL9Myosin light chain 9. (172 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
RAC3Rac family small GTPase 3. (205 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ENSPCOP00000001901Ig-like domain-containing protein. (127 aa)
ENSPCOP00000002125ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (149 aa)
ARSIArylsulfatase family member I. (572 aa)
PLXNA1Plexin A1. (1152 aa)
LOC105805812Uncharacterized protein. (172 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ITGB1Integrin beta. (585 aa)
NCK2Cytoplasmic protein. (380 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (624 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
L1CAML1 cell adhesion molecule. (1256 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1116 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (842 aa)
ENAHENAH actin regulator. (698 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
PLXNA2Plexin A2. (1909 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ROBO1Uncharacterized protein. (1334 aa)
ENSPCOP00000004990Uncharacterized protein. (268 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NTN3Netrin 3. (580 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSPCOP00000005631Protein kinase domain-containing protein. (159 aa)
NTN4Netrin 4. (628 aa)
PAK4Non-specific serine/threonine protein kinase. (588 aa)
NTN1Netrin 1. (604 aa)
RHOARas homolog family member A. (193 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (159 aa)
UNC5BUnc-5 netrin receptor B. (932 aa)
LDAHLipid droplet associated hydrolase. (350 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (619 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (749 aa)
SEMA5BSemaphorin 5B. (1173 aa)
ENSPCOP00000007290Uncharacterized protein. (174 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (665 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (777 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
PIK3R3Uncharacterized protein. (454 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
RGS3Regulator of G protein signaling 3. (913 aa)
ENSPCOP00000008391PB1 domain-containing protein. (159 aa)
ENSPCOP00000008407Sema domain-containing protein; Belongs to the semaphorin family. (244 aa)
FYNTyrosine-protein kinase. (537 aa)
DPYSL5Dihydropyrimidinase like 5. (566 aa)
SSH3Slingshot protein phosphatase 3. (660 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
PLXNA3Plexin A3. (1872 aa)
SSH2Slingshot protein phosphatase 2. (1435 aa)
NFATC4Nuclear factor of activated T cells 4. (953 aa)
LOC105822409Eph LBD domain-containing protein. (279 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
RAC2Rac family small GTPase 2. (192 aa)
KRASUncharacterized protein. (75 aa)
MYL5Myosin light chain 5. (173 aa)
ENSPCOP00000009764Ig-like domain-containing protein. (130 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SEMA3ESema domain-containing protein; Belongs to the semaphorin family. (390 aa)
EPHA2EPH receptor A2. (976 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1100 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
ENSPCOP00000010769Ig-like domain-containing protein. (119 aa)
PLXNB1Plexin B1. (2135 aa)
RHOCRas homolog family member C. (193 aa)
ENSPCOP00000011171Uncharacterized protein. (575 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
NEO1Neogenin 1. (1443 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
PARD3Par-3 family cell polarity regulator. (1296 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
SSH1Slingshot protein phosphatase 1. (1021 aa)
EPHA4EPH receptor A4. (976 aa)
CSDE1Cold shock domain containing E1. (798 aa)
RRASRAS related. (220 aa)
RYKReceptor like tyrosine kinase. (606 aa)
SLIT2Slit guidance ligand 2. (1423 aa)
SEMA5ASemaphorin 5A. (1074 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
ROBO2Roundabout guidance receptor 2. (1323 aa)
MYL12AUncharacterized protein. (172 aa)
ENSPCOP00000013931Eph LBD domain-containing protein. (358 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (211 aa)
EPHB1EPH receptor B1. (984 aa)
ILKIntegrin linked kinase. (518 aa)
SLIT3Slit guidance ligand 3. (1523 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
PLXNA4Plexin A4. (1893 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
LRRC4Leucine rich repeat containing 4. (612 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (343 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (451 aa)
LIMK1LIM domain kinase 1. (678 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
RAC1Rac family small GTPase 1. (211 aa)
EPHA10EPH receptor A10. (1008 aa)
EPHA8EPH receptor A8. (1006 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
GDF7Growth differentiation factor 7. (447 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
PIK3R2Uncharacterized protein. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (543 aa)
EPHB3EPH receptor B3. (1009 aa)
RND1Rho family GTPase 1. (232 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ABLIM3Actin binding LIM protein family member 3. (636 aa)
CFL1ADF-H domain-containing protein. (178 aa)
ROBO3Roundabout guidance receptor 3. (1385 aa)
EPHB4EPH receptor B4. (987 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
PPP3R1Uncharacterized protein. (189 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
ABLIM1Actin binding LIM protein 1. (776 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
ENSPCOP00000022056PB1 domain-containing protein. (96 aa)
ENSPCOP00000022111Uncharacterized protein. (93 aa)
CDC42Uncharacterized protein. (191 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (600 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
PTCH1Patched 1. (1449 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
EPHA3EPH receptor A3. (831 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (963 aa)
PLXNB2Plexin B2. (1841 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
SRMSTyrosine-protein kinase. (496 aa)
PLXNB3Plexin B3. (1936 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
ENSPCOP00000024978ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
ADAM15ADAM metallopeptidase domain 15. (859 aa)
UNC5AUnc-5 netrin receptor A. (818 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
ENSPCOP00000025645Uncharacterized protein. (162 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
NTNG2Netrin G2. (452 aa)
EPHA1EPH receptor A1. (942 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
NTNG1Netrin G1. (542 aa)
LIMK2LIM domain kinase 2. (638 aa)
ENSPCOP00000028080Uncharacterized protein. (597 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (786 aa)
NGEFNeuronal guanine nucleotide exchange factor. (648 aa)
PLXNC1Plexin C1. (1569 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
LOC105817025ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (218 aa)
ABLIM2Actin binding LIM protein family member 2. (645 aa)
SRGAP2Uncharacterized protein. (1071 aa)
DPYSL2Dihydropyrimidinase like 2. (677 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
UNC5CUnc-5 netrin receptor C. (850 aa)
ENSPCOP00000030916Uncharacterized protein. (524 aa)
MYL12BMyosin light chain 12B. (172 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
RHODRas homolog family member D. (210 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
SLIT1Slit guidance ligand 1. (1510 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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