STRINGSTRING
RELA RELA FOS FOS IFNGR1 IFNGR1 TRAF6 TRAF6 IFNGR2 IFNGR2 NFATC1 NFATC1 TGFB2 TGFB2 TGFBR2 TGFBR2 ENSPCOP00000001609 ENSPCOP00000001609 IL1R1 IL1R1 MAPK9 MAPK9 LOC105822640 LOC105822640 IGSF1 IGSF1 TYK2 TYK2 IFNAR2 IFNAR2 MAP2K7 MAP2K7 FOSB FOSB SOCS1 SOCS1 RELB RELB ACP5 ACP5 JUNB JUNB PPP3CA PPP3CA MAP3K7 MAP3K7 JUND JUND OSCAR OSCAR CSF1 CSF1 TEC TEC IRF9 IRF9 NCF1 NCF1 STAT1 STAT1 NCF2 NCF2 PIK3R3 PIK3R3 NFKB1 NFKB1 MAPK3 MAPK3 FCGR2A FCGR2A FYN FYN TNFRSF11A TNFRSF11A SIRPA SIRPA LOC105819868 LOC105819868 SYK SYK LOC105821782 LOC105821782 RELCH RELCH LCK LCK STAT2 STAT2 IL1B IL1B PLCG2 PLCG2 PPARG PPARG TREM2 TREM2 ENSPCOP00000012847 ENSPCOP00000012847 PPP3CC PPP3CC IL1A IL1A JAK1 JAK1 MAPK12 MAPK12 NFKBIA NFKBIA NCF4 NCF4 MAPK11 MAPK11 TRAF2 TRAF2 SQSTM1 SQSTM1 TNF TNF NFATC2 NFATC2 PIK3CA PIK3CA MAP2K1 MAP2K1 LOC105809397 LOC105809397 PIK3CB PIK3CB TYROBP TYROBP MAPK14 MAPK14 GRB2 GRB2 PIK3R2 PIK3R2 ENSPCOP00000018448 ENSPCOP00000018448 PIK3R1 PIK3R1 TGFBR1 TGFBR1 CREB1 CREB1 AKT2 AKT2 LOC105809231 LOC105809231 ENSPCOP00000019747 ENSPCOP00000019747 CTSK CTSK PPP3R1 PPP3R1 IFNG IFNG GAB2 GAB2 TAB1 TAB1 IKBKB IKBKB LCP2 LCP2 MAPK10 MAPK10 TAB2 TAB2 IFNAR1 IFNAR1 TGFB1 TGFB1 FHL2 FHL2 CALCR CALCR LOC105809546 LOC105809546 CYBA CYBA SRMS SRMS BLNK BLNK MAP3K14 MAP3K14 NFKB2 NFKB2 PPP3CB PPP3CB MAP2K6 MAP2K6 CSF1R CSF1R LOC105809548 LOC105809548 SOCS3 SOCS3 IKBKG IKBKG SPI1 SPI1 SPIB SPIB MITF MITF TNFRSF1A TNFRSF1A MAPK8 MAPK8 AKT3 AKT3 AKT1 AKT1 FCGR2B FCGR2B FOSL1 FOSL1 BTK BTK CHUK CHUK MAPK1 MAPK1 NOX1 NOX1 TNFRSF11B TNFRSF11B PIK3CD PIK3CD MAPK13 MAPK13 CYLD CYLD TNFSF11 TNFSF11 CAMK4 CAMK4 FOSL2 FOSL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
IFNGR1Interferon gamma receptor 1. (479 aa)
TRAF6TNF receptor-associated factor. (498 aa)
IFNGR2Interferon gamma receptor 2. (304 aa)
NFATC1Nuclear factor of activated T cells 1. (945 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSPCOP00000001609Ig-like domain-containing protein. (159 aa)
IL1R1Interleukin 1 receptor type 1. (516 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
IGSF1Immunoglobulin superfamily member 1. (1340 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
IFNAR2Uncharacterized protein. (520 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
RELBRELB proto-oncogene, NF-kB subunit. (552 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
OSCAROsteoclast associated Ig-like receptor. (266 aa)
CSF1Colony stimulating factor 1. (438 aa)
TECTyrosine-protein kinase. (625 aa)
IRF9Interferon regulatory factor 9. (393 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PIK3R3Uncharacterized protein. (454 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
FCGR2AUncharacterized protein. (307 aa)
FYNTyrosine-protein kinase. (537 aa)
TNFRSF11ATNF receptor superfamily member 11a. (584 aa)
SIRPAUncharacterized protein. (500 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
LOC105821782Uncharacterized protein. (380 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
LCKTyrosine-protein kinase. (417 aa)
STAT2Signal transducer and activator of transcription. (862 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (502 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
ENSPCOP00000012847IG domain-containing protein. (167 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NCF4Neutrophil cytosolic factor 4. (306 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
SQSTM1Sequestosome 1. (440 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
LOC105809397Ig-like domain-containing protein. (638 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (111 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (726 aa)
ENSPCOP00000018448Uncharacterized protein. (87 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC105809231Ig-like domain-containing protein. (264 aa)
ENSPCOP00000019747Uncharacterized protein. (330 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
PPP3R1Uncharacterized protein. (189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
LCP2Lymphocyte cytosolic protein 2. (493 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (407 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FHL2Four and a half LIM domains 2. (382 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
LOC105809546Uncharacterized protein. (506 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
SRMSTyrosine-protein kinase. (496 aa)
BLNKB cell linker. (421 aa)
MAP3K14Uncharacterized protein. (151 aa)
NFKB2Nuclear factor kappa B subunit 2. (895 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
LOC105809548Uncharacterized protein. (465 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
SPI1Spi-1 proto-oncogene. (272 aa)
SPIBETS domain-containing protein. (262 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FCGR2BUncharacterized protein. (316 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (272 aa)
BTKTyrosine-protein kinase. (647 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NOX1NADPH oxidase 1. (564 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (320 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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