STRINGSTRING
ENSPCOP00000031725 ENSPCOP00000031725 CXCL11 CXCL11 FOS FOS BPIFC BPIFC TRAF6 TRAF6 MAP2K2 MAP2K2 MAPK9 MAPK9 SPP1 SPP1 IFNAR2 IFNAR2 MAP2K7 MAP2K7 CCL5 CCL5 CD80 CD80 IRF5 IRF5 IRF3 IRF3 MAP3K7 MAP3K7 ENSPCOP00000006977 ENSPCOP00000006977 TLR9 TLR9 TRAF3 TRAF3 STAT1 STAT1 PIK3R3 PIK3R3 RELA RELA NFKB1 NFKB1 IL6 IL6 MAPK3 MAPK3 TLR3 TLR3 LOC105819868 LOC105819868 IRF7 IRF7 IL1B IL1B LY96 LY96 LOC105813852 LOC105813852 IL12B IL12B TLR1 TLR1 MAPK12 MAPK12 NFKBIA NFKBIA IRF6 IRF6 MAPK11 MAPK11 TNF TNF TLR8 TLR8 PIK3CA PIK3CA MAP2K1 MAP2K1 TMED3 TMED3 IL12A IL12A PIK3CB PIK3CB BPI BPI TBK1 TBK1 ENSPCOP00000017161 ENSPCOP00000017161 MAPK14 MAPK14 TMED7 TMED7 PIK3R2 PIK3R2 PIK3R1 PIK3R1 AKT2 AKT2 CD86 CD86 CTSK CTSK TAB1 TAB1 IKBKB IKBKB CD14 CD14 FADD FADD MAPK10 MAPK10 TAB2 TAB2 IFNAR1 IFNAR1 TIRAP TIRAP CXCL9 CXCL9 LBP LBP CASP8 CASP8 RIPK1 RIPK1 CXCL10 CXCL10 CXCL8 CXCL8 MAP2K6 MAP2K6 CD40 CD40 TICAM1 TICAM1 IKBKG IKBKG IKBKE IKBKE TOLLIP TOLLIP CCL4 CCL4 TLR4 TLR4 MAPK8 MAPK8 AKT3 AKT3 IRAK4 IRAK4 AKT1 AKT1 IRAK1 IRAK1 CHUK CHUK MAPK1 MAPK1 PIK3CD PIK3CD MAPK13 MAPK13 MYD88 MYD88 ENSPCOP00000031440 ENSPCOP00000031440 MAP2K4 MAP2K4 MAP2K3 MAP2K3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
CXCL11C-X-C motif chemokine. (100 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
BPIFCBPI fold containing family C. (507 aa)
TRAF6TNF receptor-associated factor. (498 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
SPP1Secreted phosphoprotein 1. (305 aa)
IFNAR2Uncharacterized protein. (520 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
CCL5C-C motif chemokine. (91 aa)
CD80CD80 molecule. (265 aa)
IRF5Interferon regulatory factor 5. (502 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (419 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
ENSPCOP00000006977IRF-3 domain-containing protein. (275 aa)
TLR9TIR domain-containing protein. (1029 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
PIK3R3Uncharacterized protein. (454 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL6Uncharacterized protein. (211 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
IRF7Interferon regulatory factor 7. (383 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
LY96Lymphocyte antigen 96. (160 aa)
LOC105813852C-C motif chemokine. (94 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
TLR1Toll-like receptor. (774 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IRF6Interferon regulatory factor 6. (467 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BPIBactericidal permeability increasing protein. (487 aa)
TBK1TANK binding kinase 1. (690 aa)
ENSPCOP00000017161Mitogen-activated protein kinase kinase kinase 8. (119 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
TMED7Transmembrane p24 trafficking protein 7. (224 aa)
PIK3R2Uncharacterized protein. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CD86CD86 molecule. (336 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (407 aa)
TIRAPTIR domain containing adaptor protein. (198 aa)
CXCL9C-X-C motif chemokine. (126 aa)
LBPLipopolysaccharide binding protein. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
CD40CD40 molecule. (281 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
TOLLIPToll interacting protein. (275 aa)
CCL4C-C motif chemokine. (92 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
ENSPCOP00000031440annotation not available (119 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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