STRINGSTRING
SYK SYK IRF1 IRF1 NFATC4 NFATC4 PTGS2 PTGS2 MAPK3 MAPK3 IL6 IL6 NFKB1 NFKB1 IL10 IL10 PIK3R3 PIK3R3 STAT1 STAT1 ENSPCOP00000007681 ENSPCOP00000007681 IRF9 IRF9 PAK1 PAK1 LOC105812775 LOC105812775 EGR3 EGR3 RHOA RHOA IL17D IL17D MAPKAPK2 MAPKAPK2 PPP3CA PPP3CA TMEM52B TMEM52B NRAS NRAS RAF1 RAF1 CLEC1B CLEC1B RELB RELB ITPR2 ITPR2 LSP1 LSP1 ENSPCOP00000002686 ENSPCOP00000002686 ENSPCOP00000002497 ENSPCOP00000002497 ENSPCOP00000002207 ENSPCOP00000002207 MAPK9 MAPK9 PLK5 PLK5 NFATC3 NFATC3 NFATC1 NFATC1 CLEC1A CLEC1A ARHGEF12 ARHGEF12 ENSPCOP00000000307 ENSPCOP00000000307 RELA RELA PLK3 PLK3 EGR2 EGR2 CARD9 CARD9 PYCARD PYCARD MALT1 MALT1 CYLD CYLD IL2 IL2 RRAD RRAD MAPK13 MAPK13 PIK3CD PIK3CD MAPK1 MAPK1 CHUK CHUK PTPN11 PTPN11 AKT1 AKT1 AKT3 AKT3 MAPK8 MAPK8 BCL10 BCL10 MDM2 MDM2 IKBKE IKBKE IKBKG IKBKG PRKCD PRKCD CLEC7A CLEC7A ENSPCOP00000025645 ENSPCOP00000025645 PPP3CB PPP3CB ITPR1 ITPR1 NFKB2 NFKB2 ENSPCOP00000024532 ENSPCOP00000024532 MAP3K14 MAP3K14 KSR1 KSR1 CASP8 CASP8 MRAS MRAS CLEC4D CLEC4D MAPK10 MAPK10 CBLB CBLB GEM GEM FCER1G FCER1G CCL22 CCL22 IKBKB IKBKB PPP3R1 PPP3R1 CEACAM16 CEACAM16 HRAS HRAS AKT2 AKT2 ITPR3 ITPR3 SRC SRC PIK3R1 PIK3R1 BCL3 BCL3 PIK3R2 PIK3R2 CALML4 CALML4 MAPK14 MAPK14 ENSPCOP00000017179 ENSPCOP00000017179 PIK3CB PIK3CB IL12A IL12A PIK3CA PIK3CA NFATC2 NFATC2 PVALEF PVALEF TNF TNF CLEC4G CLEC4G LOC105817503 LOC105817503 CASP1 CASP1 MAPK11 MAPK11 CEACAM1 CEACAM1 CCL17 CCL17 NFKBIA NFKBIA MAPK12 MAPK12 CALM2 CALM2 LOC105812777 LOC105812777 NLRP3 NLRP3 PPP3CC PPP3CC RRAS RRAS IL12B IL12B CSDE1 CSDE1 PLCG2 PLCG2 REM1 REM1 CLEC4E CLEC4E CALM3 CALM3 CLEC4A CLEC4A IL1B IL1B RHOC RHOC RRAS2 RRAS2 ENSPCOP00000010764 ENSPCOP00000010764 STAT2 STAT2 CLEC6A CLEC6A CALM1 CALM1 KRAS KRAS IL23A IL23A EFCAB3 EFCAB3 LOC105819868 LOC105819868
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYKSpleen associated tyrosine kinase. (637 aa)
IRF1Interferon regulatory factor. (324 aa)
NFATC4Nuclear factor of activated T cells 4. (953 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL10Interleukin 10. (178 aa)
PIK3R3Uncharacterized protein. (454 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
IRF9Interferon regulatory factor 9. (393 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
EGR3Early growth response 3. (387 aa)
RHOARas homolog family member A. (193 aa)
IL17DInterleukin 17D. (200 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TMEM52BTransmembrane protein 52B. (183 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
RELBRELB proto-oncogene, NF-kB subunit. (552 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
LSP1Uncharacterized protein. (82 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ENSPCOP00000002497Uncharacterized protein. (317 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
PLK5Polo like kinase 5. (337 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
NFATC1Nuclear factor of activated T cells 1. (945 aa)
CLEC1AUncharacterized protein. (181 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1496 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PLK3Serine/threonine-protein kinase PLK. (672 aa)
EGR2Early growth response 2. (473 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
PYCARDPYD and CARD domain containing. (195 aa)
MALT1MALT1 paracaspase. (787 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
MDM2Uncharacterized protein. (68 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CLEC7AUncharacterized protein. (62 aa)
ENSPCOP00000025645Uncharacterized protein. (162 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
NFKB2Nuclear factor kappa B subunit 2. (895 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
MAP3K14Uncharacterized protein. (151 aa)
KSR1Kinase suppressor of ras 1. (849 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CBLBCbl proto-oncogene B. (908 aa)
GEMGTP binding protein overexpressed in skeletal muscle. (160 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
CCL22C-C motif chemokine. (93 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
PPP3R1Uncharacterized protein. (189 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (420 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
SRCTyrosine-protein kinase. (543 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BCL3BCL3 transcription coactivator. (454 aa)
PIK3R2Uncharacterized protein. (726 aa)
CALML4Calmodulin like 4. (178 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
ENSPCOP00000017179C-type lectin domain-containing protein. (128 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
LOC105817503Uncharacterized protein. (349 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (254 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
CEACAM1Uncharacterized protein. (523 aa)
CCL17C-C motif chemokine. (102 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
LOC105812777Uncharacterized protein. (436 aa)
NLRP3NLR family pyrin domain containing 3. (1036 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
RRASRAS related. (220 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
CSDE1Cold shock domain containing E1. (798 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
CLEC4EC-type lectin domain family 4 member E. (218 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CLEC4AC-type lectin domain family 4 member A. (208 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
RHOCRas homolog family member C. (193 aa)
RRAS2RAS related 2. (201 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
STAT2Signal transducer and activator of transcription. (862 aa)
CLEC6AC-type lectin domain containing 6A. (158 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
KRASUncharacterized protein. (75 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
EFCAB3Uncharacterized protein. (185 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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