STRINGSTRING
EGF EGF CNTF CNTF PTPN6 PTPN6 IL2RB IL2RB JAK1 JAK1 IL12B IL12B LOC105822566 LOC105822566 IL6ST IL6ST PTPN2 PTPN2 CNTFR CNTFR LEPR LEPR IL12RB2 IL12RB2 STAT2 STAT2 CSF2 CSF2 IL22RA2 IL22RA2 SOS2 SOS2 IL13 IL13 ENSPCOP00000009641 ENSPCOP00000009641 IL23A IL23A PRLR PRLR IL24 IL24 SOS1 SOS1 IL7 IL7 STAM2 STAM2 PIAS3 PIAS3 IL2RA IL2RA STAM STAM PIM1 PIM1 IL6 IL6 IL10 IL10 PIK3R3 PIK3R3 STAT1 STAT1 LOC105819061 LOC105819061 IFNE IFNE IRF9 IRF9 IL5 IL5 IL12RB1 IL12RB1 STAT6 STAT6 IL17D IL17D ZAN ZAN LEP LEP CSF2RA CSF2RA CRLF2 CRLF2 RAF1 RAF1 LOC105820524 LOC105820524 CCND2 CCND2 SOCS5 SOCS5 IL22RA1 IL22RA1 GHR GHR IL9R IL9R JAK3 JAK3 SOCS1 SOCS1 PIAS1 PIAS1 IL5RA IL5RA MYC MYC ENSPCOP00000003605 ENSPCOP00000003605 SOCS4 SOCS4 PDGFB PDGFB IL10RA IL10RA IFNAR2 IFNAR2 EPO EPO TYK2 TYK2 TSLP TSLP LOC105815528 LOC105815528 MTOR MTOR PIAS4 PIAS4 IL19 IL19 IFNGR2 IFNGR2 IL7R IL7R OSM OSM IFNGR1 IFNGR1 LIF LIF IL4R IL4R IL9 IL9 LOC105823083 LOC105823083 IL13RA2 IL13RA2 IL2RG IL2RG BCL2L1 BCL2L1 IFNG IFNG BCL2 BCL2 IL21R IL21R FCGBP FCGBP CTF1 CTF1 CREBBP CREBBP IL27RA IL27RA CCND3 CCND3 STAT5A STAT5A IL20 IL20 IFNAR1 IFNAR1 LIFR LIFR EPOR EPOR SOCS7 SOCS7 IL3RA IL3RA IL13RA1 IL13RA1 PDGFA PDGFA STAT5B STAT5B IL21 IL21 MPL MPL MCL1 MCL1 PDGFRA PDGFRA IL22 IL22 SOCS6 SOCS6 ENSPCOP00000026834 ENSPCOP00000026834 LOC105816126 LOC105816126 SOCS3 SOCS3 ENSPCOP00000027781 ENSPCOP00000027781 STAT4 STAT4 AKT3 AKT3 ENSPCOP00000028627 ENSPCOP00000028627 AKT1 AKT1 IL6R IL6R PTPN11 PTPN11 CSF2RB CSF2RB CCND1 CCND1 LOC105819005 LOC105819005 STAT3 STAT3 PIK3CD PIK3CD CISH CISH PDGFRB PDGFRB IL2 IL2 IL20RA IL20RA CSF3 CSF3 PIAS2 PIAS2 FHL1 FHL1 IL15RA IL15RA IL23R IL23R AOX1 AOX1 IFNL1 IFNL1 EP300 EP300 ENSPCOP00000019392 ENSPCOP00000019392 AKT2 AKT2 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR IL15 IL15 GRB2 GRB2 IL4 IL4 PRL PRL IFNLR1 IFNLR1 PIK3CB PIK3CB IL12A IL12A GFAP GFAP IL11 IL11 PIK3CA PIK3CA CSF3R CSF3R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFEpidermal growth factor. (1132 aa)
CNTFCiliary neurotrophic factor. (198 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
IL2RBInterleukin 2 receptor subunit beta. (558 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
LOC105822566Uncharacterized protein. (223 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
LEPRLeptin receptor. (1055 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (780 aa)
STAT2Signal transducer and activator of transcription. (862 aa)
CSF2Colony stimulating factor 2. (146 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
IL13Interleukin 13. (132 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (523 aa)
IL24Interleukin 24. (220 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
IL7Interleukin 7. (133 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
IL2RAInterleukin 2 receptor subunit alpha. (271 aa)
STAMVHS domain-containing protein. (280 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (401 aa)
IL6Uncharacterized protein. (211 aa)
IL10Interleukin 10. (178 aa)
PIK3R3Uncharacterized protein. (454 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
LOC105819061Uncharacterized protein. (1343 aa)
IFNEInterferon epsilon. (178 aa)
IRF9Interferon regulatory factor 9. (393 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (133 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (665 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
IL17DInterleukin 17D. (200 aa)
ZANZonadhesin (gene/pseudogene). (2373 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CSF2RAFibronectin type-III domain-containing protein. (388 aa)
CRLF2Cytokine receptor like factor 2. (384 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LOC105820524Uncharacterized protein. (201 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
SOCS5Uncharacterized protein. (536 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (573 aa)
GHRGrowth hormone receptor. (559 aa)
IL9RFibronectin type-III domain-containing protein. (345 aa)
JAK3Tyrosine-protein kinase. (1123 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
PIAS1Protein inhibitor of activated STAT 1. (640 aa)
IL5RAInterleukin 5 receptor subunit alpha. (333 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ENSPCOP00000003605LIFR_D2 domain-containing protein. (310 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
IFNAR2Uncharacterized protein. (520 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
TSLPThymic stromal lymphopoietin. (158 aa)
LOC105815528Uncharacterized protein. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PIAS4Protein inhibitor of activated STAT 4. (465 aa)
IL19Interleukin 19. (146 aa)
IFNGR2Interferon gamma receptor 2. (304 aa)
IL7RInterleukin 7 receptor. (456 aa)
OSMOncostatin M. (251 aa)
IFNGR1Interferon gamma receptor 1. (479 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
IL4RInterleukin 4 receptor. (808 aa)
IL9Interleukin 9. (144 aa)
LOC105823083Uncharacterized protein. (215 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (285 aa)
IL2RGFibronectin type-III domain-containing protein. (386 aa)
BCL2L1BCL2 like 1. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
IL21RInterleukin 21 receptor. (547 aa)
FCGBPUncharacterized protein. (1920 aa)
CTF1Cardiotrophin 1. (197 aa)
CREBBPCREB binding protein. (2449 aa)
IL27RAInterleukin 27 receptor subunit alpha. (637 aa)
CCND3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
STAT5ASignal transducer and activator of transcription. (805 aa)
IL20Interleukin 20. (126 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (407 aa)
LIFRLIF receptor subunit alpha. (1070 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
SOCS7Suppressor of cytokine signaling 7. (577 aa)
IL3RAInterleukin 3 receptor subunit alpha. (377 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (423 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
STAT5BSignal transducer and activator of transcription. (667 aa)
IL21Interleukin 21. (110 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (634 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
IL22Interleukin 22. (179 aa)
SOCS6Uncharacterized protein. (535 aa)
ENSPCOP00000026834Uncharacterized protein. (276 aa)
LOC105816126Suppressor of cytokine signaling 6. (535 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ENSPCOP00000027781Uncharacterized protein. (82 aa)
STAT4Signal transducer and activator of transcription. (628 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSPCOP00000028627Cyclin_C domain-containing protein. (259 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL6RInterleukin 6 receptor. (469 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (906 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
LOC105819005Uncharacterized protein. (1243 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CISHCytokine inducible SH2 containing protein. (274 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL20RAInterleukin 20 receptor subunit alpha. (556 aa)
CSF3Colony stimulating factor 3. (199 aa)
PIAS2Protein inhibitor of activated STAT 2. (573 aa)
FHL1Four and a half LIM domains 1. (323 aa)
IL15RASushi domain-containing protein. (339 aa)
IL23RInterleukin 23 receptor. (602 aa)
AOX1Aldehyde oxidase 1. (1303 aa)
IFNL1Interferon lambda 1. (191 aa)
EP300E1A binding protein p300. (2424 aa)
ENSPCOP00000019392SOCS box domain-containing protein. (458 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (135 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PRLProlactin. (231 aa)
IFNLR1Fibronectin type-III domain-containing protein. (244 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa)
IL11Interleukin 11. (199 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
CSF3RColony stimulating factor 3 receptor. (835 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (16%) [HD]