STRINGSTRING
INPPL1 INPPL1 ENSPCOP00000022111 ENSPCOP00000022111 ENSPCOP00000022032 ENSPCOP00000022032 GAB2 GAB2 CFL1 CFL1 ASAP3 ASAP3 ENSPCOP00000019705 ENSPCOP00000019705 VAV3 VAV3 PIP5K1C PIP5K1C LOC105811778 LOC105811778 AKT2 AKT2 MARCKSL1 MARCKSL1 PLA2G4E PLA2G4E PIK3R1 PIK3R1 PIK3R2 PIK3R2 CRK CRK PLA2G4D PLA2G4D LIMK1 LIMK1 PIK3CB PIK3CB WASF3 WASF3 GSN GSN ASAP2 ASAP2 MAP2K1 MAP2K1 PIK3CA PIK3CA LAT LAT VAV1 VAV1 LOC105822770 LOC105822770 RPS6KB2 RPS6KB2 INPP5D INPP5D WASF2 WASF2 ARPC4 ARPC4 ENSPCOP00000012847 ENSPCOP00000012847 PLA2G4B PLA2G4B PLCG2 PLCG2 HCK HCK BIN1 BIN1 SPHK1 SPHK1 ARPC3 ARPC3 LOC105821782 LOC105821782 ENSPCOP00000009588 ENSPCOP00000009588 SYK SYK ENSPCOP00000009427 ENSPCOP00000009427 SCIN SCIN PLA2G4A PLA2G4A FCGR2A FCGR2A MAPK3 MAPK3 PIK3R3 PIK3R3 PLPP1 PLPP1 VAV2 VAV2 GOLGA2 GOLGA2 NCF1 NCF1 PLA2G6 PLA2G6 PAK1 PAK1 MYO10 MYO10 ARPC5L ARPC5L ARPC1A ARPC1A VASP VASP RAF1 RAF1 PLPP2 PLPP2 ENSPCOP00000004655 ENSPCOP00000004655 CFL2 CFL2 WASF1 WASF1 PIP5K1A PIP5K1A ARPC1B ARPC1B MARCKS MARCKS ENSPCOP00000002927 ENSPCOP00000002927 AMPH AMPH ASAP1 ASAP1 PIP5K1B PIP5K1B ENSPCOP00000002125 ENSPCOP00000002125 PRKCG PRKCG ARPC2 ARPC2 PLD2 PLD2 ENSPCOP00000000994 ENSPCOP00000000994 SPHK2 SPHK2 ARF6 ARF6 PLD1 PLD1 CDC42 CDC42 ARPC5 ARPC5 PLA2G4F PLA2G4F PLPP3 PLPP3 PLCG1 PLCG1 LYN LYN ENSPCOP00000024978 ENSPCOP00000024978 DNM2 DNM2 PRKCE PRKCE PRKCD PRKCD JMJD7 JMJD7 ENSPCOP00000027517 ENSPCOP00000027517 LIMK2 LIMK2 ENSPCOP00000027946 ENSPCOP00000027946 AKT3 AKT3 AKT1 AKT1 PRKCA PRKCA PRKCB PRKCB MAPK1 MAPK1 CRKL CRKL LOC105817025 LOC105817025 PIK3CD PIK3CD LOC105810942 LOC105810942 RPS6KB1 RPS6KB1 WAS WAS FCGR2B FCGR2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
ENSPCOP00000022111Uncharacterized protein. (93 aa)
ENSPCOP00000022032Ig-like domain-containing protein. (95 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
CFL1ADF-H domain-containing protein. (178 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (904 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (682 aa)
LOC105811778WD_REPEATS_REGION domain-containing protein. (354 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MARCKSL1Uncharacterized protein. (200 aa)
PLA2G4EPhospholipase A2. (819 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PLA2G4DPhospholipase A2. (818 aa)
LIMK1LIM domain kinase 1. (678 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
WASF3WASP family member 3. (485 aa)
GSNGelsolin. (778 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (1006 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
LATLinker for activation of T cells. (236 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
LOC105822770Ig-like domain-containing protein. (140 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1178 aa)
WASF2WASP family member 2. (497 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
ENSPCOP00000012847IG domain-containing protein. (167 aa)
PLA2G4BPhospholipase A2. (781 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
HCKTyrosine-protein kinase. (524 aa)
BIN1Bridging integrator 1. (594 aa)
SPHK1Sphingosine kinase 1. (469 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
LOC105821782Uncharacterized protein. (380 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
ENSPCOP00000009427Uncharacterized protein. (189 aa)
SCINScinderin. (589 aa)
PLA2G4APhospholipase A2. (749 aa)
FCGR2AUncharacterized protein. (307 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
VAV2Vav guanine nucleotide exchange factor 2. (771 aa)
GOLGA2Uncharacterized protein. (926 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2080 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ARPC1AUncharacterized protein. (188 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (379 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PLPP2Phospholipid phosphatase 2. (304 aa)
ENSPCOP00000004655WD_REPEATS_REGION domain-containing protein. (262 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
WASF1WASP family member 1. (559 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (598 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (334 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
AMPHAmphiphysin. (688 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (988 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
ENSPCOP00000002125ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (292 aa)
PLD2Phospholipase. (932 aa)
ENSPCOP00000000994Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (173 aa)
SPHK2Sphingosine kinase 2. (660 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PLD1Phospholipase. (1040 aa)
CDC42Uncharacterized protein. (191 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (126 aa)
PLA2G4FPhospholipase A2. (847 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
LYNTyrosine-protein kinase. (512 aa)
ENSPCOP00000024978ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
JMJD7Jumonji domain containing 7. (316 aa)
ENSPCOP00000027517Uncharacterized protein. (196 aa)
LIMK2LIM domain kinase 2. (638 aa)
ENSPCOP00000027946Uncharacterized protein. (298 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
LOC105817025ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (218 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC105810942WD_REPEATS_REGION domain-containing protein. (347 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
WASWASP actin nucleation promoting factor. (503 aa)
FCGR2BUncharacterized protein. (316 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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