STRINGSTRING
NFKBIA NFKBIA MAPK11 MAPK11 TRAF2 TRAF2 TNF TNF PIK3CA PIK3CA CXCL6 CXCL6 MAP3K5 MAP3K5 CREB3L4 CREB3L4 MAP2K1 MAP2K1 PIK3CB PIK3CB TRADD TRADD MLKL MLKL ENSPCOP00000017161 ENSPCOP00000017161 VCAM1 VCAM1 MAPK14 MAPK14 CASP3 CASP3 ICAM1 ICAM1 ATF6B ATF6B CASP7 CASP7 MMP14 MMP14 ATF4 ATF4 IL15 IL15 PIK3R2 PIK3R2 BCL3 BCL3 PIK3R1 PIK3R1 CREB1 CREB1 AKT2 AKT2 CASP10 CASP10 DAB2IP DAB2IP RFWD3 RFWD3 CEACAM16 CEACAM16 CX3CL1 CX3CL1 DNM1L DNM1L TAB1 TAB1 IKBKB IKBKB VEGFC VEGFC BIRC2 BIRC2 FADD FADD MAPK10 MAPK10 TAB2 TAB2 CREB5 CREB5 MMP3 MMP3 CASP8 CASP8 RIPK1 RIPK1 CXCL10 CXCL10 MAP3K14 MAP3K14 MAP2K6 MAP2K6 CREB3 CREB3 CREB3L1 CREB3L1 ATF2 ATF2 SOCS3 SOCS3 IKBKG IKBKG TNFRSF1A TNFRSF1A MAPK8 MAPK8 CEBPB CEBPB AKT3 AKT3 TRAF1 TRAF1 AKT1 AKT1 NOD2 NOD2 CHUK CHUK MAPK1 MAPK1 PIK3CD PIK3CD MAPK13 MAPK13 TNFAIP3 TNFAIP3 BAG4 BAG4 IL18R1 IL18R1 TRAF5 TRAF5 RIPK3 RIPK3 ENSPCOP00000031440 ENSPCOP00000031440 MAP2K4 MAP2K4 MAP2K3 MAP2K3 VEGFD VEGFD ENSPCOP00000031725 ENSPCOP00000031725 RELA RELA TNFRSF1B TNFRSF1B CCL20 CCL20 FOS FOS LIF LIF FAS FAS MAPK9 MAPK9 MAP2K7 MAP2K7 CCL5 CCL5 BIRC3 BIRC3 ITCH ITCH CFLAR CFLAR RPS6KA5 RPS6KA5 JAG1 JAG1 JUNB JUNB MAP3K7 MAP3K7 CSF1 CSF1 EDN1 EDN1 RPS6KA4 RPS6KA4 TRAF3 TRAF3 SELE SELE MAPK12 MAPK12 CREB3L3 CREB3L3 TAB3 TAB3 MMP9 MMP9 MMP10 MMP10 LTA LTA PGAM5 PGAM5 IL1B IL1B CSF2 CSF2 LOC105819868 LOC105819868 CCDC88B CCDC88B IRF1 IRF1 PTGS2 PTGS2 CCL2 CCL2 CREB3L2 CREB3L2 MAPK3 MAPK3 IL6 IL6 NFKB1 NFKB1 PIK3R3 PIK3R3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFKBIANFKB inhibitor alpha. (314 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
CXCL6C-X-C motif chemokine. (116 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TRADDTNFRSF1A associated via death domain. (309 aa)
MLKLMixed lineage kinase domain like pseudokinase. (419 aa)
ENSPCOP00000017161Mitogen-activated protein kinase kinase kinase 8. (119 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
ATF6BActivating transcription factor 6 beta. (702 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (341 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ATF4Activating transcription factor 4. (351 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (135 aa)
PIK3R2Uncharacterized protein. (726 aa)
BCL3BCL3 transcription coactivator. (454 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (528 aa)
DAB2IPDAB2 interacting protein. (1209 aa)
RFWD3Ring finger and WD repeat domain 3. (633 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (420 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (405 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
CXCL10C-X-C motif chemokine. (98 aa)
MAP3K14Uncharacterized protein. (151 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRAF1TNF receptor-associated factor. (415 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TNFAIP3TNF alpha induced protein 3. (792 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (536 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
ENSPCOP00000031440annotation not available (119 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (319 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
TNFRSF1BTNF receptor superfamily member 1B. (449 aa)
CCL20C-C motif chemokine. (96 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
FASFas cell surface death receptor. (309 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
CCL5C-C motif chemokine. (91 aa)
BIRC3Baculoviral IAP repeat containing 3. (597 aa)
ITCHE3 ubiquitin-protein ligase. (860 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (333 aa)
RPS6KA5Ribosomal protein S6 kinase A5. (643 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
CSF1Colony stimulating factor 1. (438 aa)
EDN1Endothelin 1. (193 aa)
RPS6KA4Ribosomal protein S6 kinase. (764 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
SELESelectin E. (610 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (710 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
MMP10Matrix metallopeptidase 10; Belongs to the peptidase M10A family. (287 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (289 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CSF2Colony stimulating factor 2. (146 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
CCDC88BCoiled-coil domain containing 88B. (1474 aa)
IRF1Interferon regulatory factor. (324 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CCL2C-C motif chemokine. (99 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (508 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
PIK3R3Uncharacterized protein. (454 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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