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ADCY8 ADCY8 ASIC4 ASIC4 MAP2K6 MAP2K6 PRKCE PRKCE PRKCD PRKCD PLCB4 PLCB4 JMJD7 JMJD7 ASIC2 ASIC2 PRKCQ PRKCQ ALOX12 ALOX12 PPP1CA PPP1CA TRPA1 TRPA1 LOC105806374 LOC105806374 MAPK8 MAPK8 PRKACA PRKACA PRKCA PRKCA PRKCB PRKCB ADCY5 ADCY5 HTR2B HTR2B PLCB3 PLCB3 PIK3CD PIK3CD MAPK13 MAPK13 TRPV4 TRPV4 GNAS GNAS MAP2K3 MAP2K3 CAMK2A CAMK2A PLCG1 PLCG1 ENSPCOP00000024532 ENSPCOP00000024532 ADCY9 ADCY9 ADCY7 ADCY7 ASIC3 ASIC3 TRPV1 TRPV1 PLA2G4F PLA2G4F CAMK2G CAMK2G MAPK10 MAPK10 PPP1CC PPP1CC CAMK2D CAMK2D PTGER4 PTGER4 TRPM8 TRPM8 LOC105814130 LOC105814130 CYP2W1 CYP2W1 ASIC1 ASIC1 IGF1 IGF1 TRPV2 TRPV2 PLA2G4E PLA2G4E ITPR3 ITPR3 SRC SRC PIK3R1 PIK3R1 PIK3R2 PIK3R2 BDKRB1 BDKRB1 PLA2G4D PLA2G4D CALML4 CALML4 MAPK14 MAPK14 ADCY3 ADCY3 LOC105806372 LOC105806372 PIK3CB PIK3CB PIK3CA PIK3CA ASIC5 ASIC5 PVALEF PVALEF MAPK11 MAPK11 PLCB2 PLCB2 MAPK12 MAPK12 IL1RAP IL1RAP CALM2 CALM2 LOC105819725 LOC105819725 PLA2G4B PLA2G4B PLCG2 PLCG2 TRPV3 TRPV3 ADCY4 ADCY4 ADCY1 ADCY1 CALM3 CALM3 PPP1CB PPP1CB HTR2C HTR2C IL1B IL1B CYP4B1 CYP4B1 ENSPCOP00000010764 ENSPCOP00000010764 NTRK1 NTRK1 LOC105806815 LOC105806815 CALM1 CALM1 ENSPCOP00000009588 ENSPCOP00000009588 LOC105819868 LOC105819868 PLA2G4A PLA2G4A ENSPCOP00000008641 ENSPCOP00000008641 PIK3R3 PIK3R3 ITPR1 ITPR1 ENSPCOP00000007681 ENSPCOP00000007681 PLA2G6 PLA2G6 BDKRB2 BDKRB2 CAMK2B CAMK2B PRKACB PRKACB HTR2A HTR2A PLCB1 PLCB1 KNG1 KNG1 ITPR2 ITPR2 PTGER2 PTGER2 ADCY6 ADCY6 ARSI ARSI ENSPCOP00000002207 ENSPCOP00000002207 MAPK9 MAPK9 PRKCG PRKCG IL1R1 IL1R1 ADCY2 ADCY2 AADACL2 AADACL2 PTRHD1 PTRHD1 ENSPCOP00000000307 ENSPCOP00000000307
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (666 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
JMJD7Jumonji domain containing 7. (316 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (563 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1091 aa)
LOC105806374Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
GNASUncharacterized protein. (394 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (537 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (845 aa)
PLA2G4FPhospholipase A2. (847 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (600 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1104 aa)
LOC105814130Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (490 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
IGF1Insulin like growth factor 1. (208 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (762 aa)
PLA2G4EPhospholipase A2. (819 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
SRCTyrosine-protein kinase. (543 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
BDKRB1Bradykinin receptor B1. (274 aa)
PLA2G4DPhospholipase A2. (818 aa)
CALML4Calmodulin like 4. (178 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
LOC105806372Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (486 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
LOC105819725Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (658 aa)
PLA2G4BPhospholipase A2. (781 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (790 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (282 aa)
HTR2C5-hydroxytryptamine receptor 2C. (459 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
LOC105806815Uncharacterized protein; Belongs to the cytochrome P450 family. (284 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
PLA2G4APhospholipase A2. (749 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
PIK3R3Uncharacterized protein. (454 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (665 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
KNG1Uncharacterized protein. (391 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
ARSIArylsulfatase family member I. (572 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
IL1R1Interleukin 1 receptor type 1. (516 aa)
ADCY2Adenylate cyclase 2. (904 aa)
AADACL2Arylacetamide deacetylase like 2. (377 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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