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KCNN4 KCNN4 ATP1B2 ATP1B2 ATP1A2 ATP1A2 GNAS GNAS PLCB3 PLCB3 ADCY5 ADCY5 PRKCB PRKCB PRKCA PRKCA PRKACA PRKACA FAP FAP STX1A STX1A KCNN2 KCNN2 PLCB4 PLCB4 ATF2 ATF2 CREB3L1 CREB3L1 CREB3 CREB3 CACNA1F CACNA1F GIP GIP CAMK2A CAMK2A KCNMA1 KCNMA1 ADCY9 ADCY9 ADCY7 ADCY7 ATP1B4 ATP1B4 CREB5 CREB5 CAMK2G CAMK2G CAMK2D CAMK2D GLP1R GLP1R CACNA1S CACNA1S CCKAR CCKAR RAPGEF4 RAPGEF4 GCK GCK KCNMB2 KCNMB2 TNIK TNIK KCNMB1 KCNMB1 ATP1B3 ATP1B3 CREB1 CREB1 ITPR3 ITPR3 ATP1A3 ATP1A3 ATF4 ATF4 ATF6B ATF6B RIMS2 RIMS2 CACNA1C CACNA1C ADCY3 ADCY3 CREB3L4 CREB3L4 KCNMB4 KCNMB4 ADCYAP1R1 ADCYAP1R1 KCNU1 KCNU1 PLCB2 PLCB2 RAB3B RAB3B ABCC8 ABCC8 CACNA1D CACNA1D CREB3L3 CREB3L3 ATP1A1 ATP1A1 ATP1B1 ATP1B1 ADCY8 ADCY8 ADCY4 ADCY4 ADCY1 ADCY1 INS INS RYR2 RYR2 PCLO PCLO GCG GCG LOC105811170 LOC105811170 ENSPCOP00000009588 ENSPCOP00000009588 ENSPCOP00000008641 ENSPCOP00000008641 CREB3L2 CREB3L2 SLC2A2 SLC2A2 KCNN3 KCNN3 ATP1A4 ATP1A4 CAMK2B CAMK2B PRKACB PRKACB PLCB1 PLCB1 RAB3A RAB3A RAB3C RAB3C CCK CCK KCNN1 KCNN1 ADCYAP1 ADCYAP1 VAMP2 VAMP2 FXYD2 FXYD2 KCNJ11 KCNJ11 ADCY6 ADCY6 KCNMB3 KCNMB3 ARSI ARSI PDX1 PDX1 SLC2A1 SLC2A1 ENSPCOP00000002072 ENSPCOP00000002072 PRKCG PRKCG ADCY2 ADCY2 PTRHD1 PTRHD1 SNAP25 SNAP25 TRPM4 TRPM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNN4Potassium calcium-activated channel subfamily N member 4. (427 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
GNASUncharacterized protein. (394 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (840 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1973 aa)
GIPGastric inhibitory polypeptide. (150 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1286 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (352 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (600 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (451 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1544 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (430 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
GCKPhosphotransferase. (466 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
TNIKTRAF2 and NCK interacting kinase. (1363 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1080 aa)
ATF4Activating transcription factor 4. (351 aa)
ATF6BActivating transcription factor 6 beta. (702 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1081 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1111 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RYR2Ryanodine receptor 2. (4825 aa)
PCLOPiccolo presynaptic cytomatrix protein. (4274 aa)
GCGGlucagon. (180 aa)
LOC105811170C2 domain-containing protein. (285 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (508 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (734 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1031 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (665 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
CCKCholecystokinin. (115 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (543 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (277 aa)
ARSIArylsulfatase family member I. (572 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (495 aa)
ENSPCOP00000002072C2 domain-containing protein. (239 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY2Adenylate cyclase 2. (904 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1204 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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