STRINGSTRING
ENSPCOP00000031725 ENSPCOP00000031725 MAP2K3 MAP2K3 MAP2K4 MAP2K4 GNAS GNAS RRAD RRAD MAPK13 MAPK13 PLCB3 PLCB3 MAPK1 MAPK1 ADCY5 ADCY5 PRKCB PRKCB PRKCA PRKCA PRKACA PRKACA MAPK8 MAPK8 PTK2B PTK2B JMJD7 JMJD7 PLCB4 PLCB4 MAP3K2 MAP3K2 PRKCD PRKCD MAP2K6 MAP2K6 CACNA1F CACNA1F ITPR1 ITPR1 PTX3 PTX3 CAMK2A CAMK2A ENSPCOP00000024532 ENSPCOP00000024532 ADCY9 ADCY9 ADCY7 ADCY7 GNRH1 GNRH1 PLA2G4F PLA2G4F CAMK2G CAMK2G CDC42 CDC42 MAPK10 MAPK10 CAMK2D CAMK2D GEM GEM CACNA1S CACNA1S HRAS HRAS PLA2G4E PLA2G4E ITPR3 ITPR3 SRC SRC EGFR EGFR ATF4 ATF4 MMP14 MMP14 PLA2G4D PLA2G4D GRB2 GRB2 CALML4 CALML4 MAPK14 MAPK14 CACNA1C CACNA1C ADCY3 ADCY3 MAP3K3 MAP3K3 MAP2K1 MAP2K1 ENSPCOP00000015906 ENSPCOP00000015906 MAPK7 MAPK7 PVALEF PVALEF MAPK11 MAPK11 PLCB2 PLCB2 MAPK12 MAPK12 CALM2 CALM2 FSHB FSHB CACNA1D CACNA1D PLA2G4B PLA2G4B CSDE1 CSDE1 ENSPCOP00000012404 ENSPCOP00000012404 ADCY8 ADCY8 CAMK2B CAMK2B ENSPCOP00000007681 ENSPCOP00000007681 MMP2 MMP2 MAP3K4 MAP3K4 MAPK3 MAPK3 ENSPCOP00000008641 ENSPCOP00000008641 PLA2G4A PLA2G4A SOS1 SOS1 LOC105819868 LOC105819868 EFCAB3 EFCAB3 ENSPCOP00000009588 ENSPCOP00000009588 KRAS KRAS CALM1 CALM1 SOS2 SOS2 MAP3K1 MAP3K1 ENSPCOP00000010764 ENSPCOP00000010764 CALM3 CALM3 ADCY1 ADCY1 ADCY4 ADCY4 REM1 REM1 PLD1 PLD1 ENSPCOP00000000307 ENSPCOP00000000307 LOC105809276 LOC105809276 EGR1 EGR1 ELK1 ELK1 PTRHD1 PTRHD1 ELK3 ELK3 PLD2 PLD2 MAP2K2 MAP2K2 ADCY2 ADCY2 MAPK9 MAPK9 ENSPCOP00000002207 ENSPCOP00000002207 ARSI ARSI ADCY6 ADCY6 ENSPCOP00000002686 ENSPCOP00000002686 MAP2K7 MAP2K7 ENSPCOP00000002927 ENSPCOP00000002927 ITPR2 ITPR2 RAF1 RAF1 NRAS NRAS PLCB1 PLCB1 HBEGF HBEGF PRKACB PRKACB GNRHR GNRHR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
GNASUncharacterized protein. (394 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
JMJD7Jumonji domain containing 7. (316 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (619 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1973 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
PTX3Pentraxin 3. (382 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
PLA2G4FPhospholipase A2. (847 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (600 aa)
CDC42Uncharacterized protein. (191 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
GEMGTP binding protein overexpressed in skeletal muscle. (160 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1544 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLA2G4EPhospholipase A2. (819 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
SRCTyrosine-protein kinase. (543 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ATF4Activating transcription factor 4. (351 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
PLA2G4DPhospholipase A2. (818 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CALML4Calmodulin like 4. (178 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (653 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
ENSPCOP00000015906Uncharacterized protein. (105 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
PLA2G4BPhospholipase A2. (781 aa)
CSDE1Cold shock domain containing E1. (798 aa)
ENSPCOP00000012404Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (125 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (665 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1598 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
PLA2G4APhospholipase A2. (749 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
EFCAB3Uncharacterized protein. (185 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
KRASUncharacterized protein. (75 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
PLD1Phospholipase. (1040 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
LOC105809276Cys_knot domain-containing protein. (146 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
ELK1ETS transcription factor ELK1. (430 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ELK3ETS transcription factor ELK3. (407 aa)
PLD2Phospholipase. (932 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ADCY2Adenylate cyclase 2. (904 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
ARSIArylsulfatase family member I. (572 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (204 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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