144 items (Propithecus coquereli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa)
	ENSPCOP00000000307	Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
	POMC	Proopiomelanocortin. (258 aa)
	SHC1	SHC adaptor protein 1. (582 aa)
	KRT17	Keratin 17; Belongs to the intermediate filament family. (433 aa)
	KRT16	Keratin 16; Belongs to the intermediate filament family. (472 aa)
	GNAS	Uncharacterized protein. (394 aa)
	KRT18	IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (816 aa)
	GNAO1	G protein subunit alpha o1. (354 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	CEP152	Centrosomal protein 152. (1655 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
	CCDC170	Coiled-coil domain containing 170. (653 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	ENSPCOP00000028553	HATPase_c domain-containing protein. (333 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	TFF1	Trefoil factor 1. (84 aa)
	PGR	Nuclear receptor domain-containing protein. (592 aa)
	KRT26	Keratin 26; Belongs to the intermediate filament family. (474 aa)
	SP1	Sp1 transcription factor. (788 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (423 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	KRT28	Keratin 28; Belongs to the intermediate filament family. (464 aa)
	KRT32	Keratin 32; Belongs to the intermediate filament family. (450 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	HSP90B1	HATPase_c domain-containing protein. (793 aa)
	CREB3	cAMP responsive element binding protein 3. (373 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
	ENSPCOP00000024532	Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	KRT39	Keratin 39; Belongs to the intermediate filament family. (491 aa)
	RARA	Retinoic acid receptor alpha. (472 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
	KRT27	Keratin 27; Belongs to the intermediate filament family. (459 aa)
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (501 aa)
	LOC105823250	IF rod domain-containing protein; Belongs to the intermediate filament family. (429 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	KRT35	Keratin 35; Belongs to the intermediate filament family. (455 aa)
	BCL2	BCL2 apoptosis regulator. (234 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	SHC3	SHC adaptor protein 3. (596 aa)
	KRT19	Keratin 19; Belongs to the intermediate filament family. (406 aa)
	ENSPCOP00000019409	Uncharacterized protein; Belongs to the heat shock protein 70 family. (568 aa)
	ENSPCOP00000019371	Uncharacterized protein; Belongs to the heat shock protein 70 family. (554 aa)
	LOC105826440	IF rod domain-containing protein; Belongs to the intermediate filament family. (419 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	CREB1	cAMP responsive element binding protein 1. (280 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
	SRC	Tyrosine-protein kinase. (543 aa)
	ENSPCOP00000018566	Uncharacterized protein. (113 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PIK3R2	Uncharacterized protein. (726 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	FKBP5	Peptidylprolyl isomerase. (457 aa)
	NCOA3	Nuclear receptor coactivator. (1410 aa)
	GRM1	Glutamate metabotropic receptor 1. (1188 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	LOC105812452	HATPase_c domain-containing protein. (680 aa)
	IFITM10	Interferon induced transmembrane protein 10. (189 aa)
	ATF6B	Activating transcription factor 6 beta. (702 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	CALML4	Calmodulin like 4. (178 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
	NCOA1	Nuclear receptor coactivator 1. (1270 aa)
	KRT15	Keratin 15; Belongs to the intermediate filament family. (450 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	FKBP4	Peptidylprolyl isomerase. (459 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ENSPCOP00000015970	IF rod domain-containing protein; Belongs to the intermediate filament family. (311 aa)
	GABBR2	Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1. (377 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (395 aa)
	PIK3CA	Phosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
	PVALEF	Parvalbumin like EF-hand containing. (126 aa)
	KRT20	Keratin 20; Belongs to the intermediate filament family. (433 aa)
	KRT14	Keratin 14; Belongs to the intermediate filament family. (479 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (479 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (138 aa)
	SHC2	Uncharacterized protein. (578 aa)
	KRT24	Keratin 24; Belongs to the intermediate filament family. (520 aa)
	NCOA2	Nuclear receptor coactivator. (1465 aa)
	KRT10	Keratin 10; Belongs to the intermediate filament family. (553 aa)
	KRT40	Keratin 40; Belongs to the intermediate filament family. (431 aa)
	CSDE1	Cold shock domain containing E1. (798 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (456 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (419 aa)
	MMP9	Matrix metallopeptidase 9. (709 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (393 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	CALM3	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	KRT25	Keratin 25; Belongs to the intermediate filament family. (450 aa)
	ENSPCOP00000010764	EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
	KRT9	Keratin 9; Belongs to the intermediate filament family. (644 aa)
	ENSPCOP00000009948	Uncharacterized protein. (605 aa)
	NOS3	Nitric oxide synthase 3. (994 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (150 aa)
	KRAS	Uncharacterized protein. (75 aa)
	KRT23	Keratin 23; Belongs to the intermediate filament family. (422 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	ENSPCOP00000008641	Uncharacterized protein. (715 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (508 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	KRT13	Keratin 13; Belongs to the intermediate filament family. (436 aa)
	PIK3R3	Uncharacterized protein. (454 aa)
	MMP2	Matrix metallopeptidase 2. (552 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (650 aa)
	ENSPCOP00000007681	EF-hand domain-containing protein. (132 aa)
	KRT36	Keratin 36; Belongs to the intermediate filament family. (467 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	TGFA	Transforming growth factor alpha. (190 aa)
	LOC105822779	Uncharacterized protein. (325 aa)
	ENSPCOP00000007290	Uncharacterized protein. (174 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (715 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (601 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
	HSPA6	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	PLCB1	Phosphoinositide phospholipase C. (1010 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	KRT12	Keratin 12; Belongs to the intermediate filament family. (497 aa)
	ESR2	Estrogen receptor 2. (471 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
	ENSPCOP00000002686	CSD_1 domain-containing protein. (293 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	ENSPCOP00000002207	Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
	ADCY2	Adenylate cyclase 2. (904 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSPCOP00000011503	ENSPCOP00000001482	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2.	0.651
ADCY1	ADCY4	ENSPCOP00000011503	ENSPCOP00000011755	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.636
ADCY1	ADCY5	ENSPCOP00000011503	ENSPCOP00000029755	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.634
ADCY1	ADCY6	ENSPCOP00000011503	ENSPCOP00000002439	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.635
ADCY1	ADCY7	ENSPCOP00000011503	ENSPCOP00000024141	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.665
ADCY1	ADCY9	ENSPCOP00000011503	ENSPCOP00000024273	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.819
ADCY1	AKT1	ENSPCOP00000011503	ENSPCOP00000028969	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.866
ADCY1	AKT2	ENSPCOP00000011503	ENSPCOP00000018910	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.866
ADCY1	AKT3	ENSPCOP00000011503	ENSPCOP00000028519	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.866
ADCY1	CALM1	ENSPCOP00000011503	ENSPCOP00000009692	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.683
ADCY1	CALM2	ENSPCOP00000011503	ENSPCOP00000013912	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.624
ADCY1	CALM3	ENSPCOP00000011503	ENSPCOP00000011445	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.683
ADCY1	CALML4	ENSPCOP00000011503	ENSPCOP00000017539	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.900
ADCY1	CSDE1	ENSPCOP00000011503	ENSPCOP00000012627	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cold shock domain containing E1.	0.486
ADCY1	ENSPCOP00000000307	ENSPCOP00000011503	ENSPCOP00000000307	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.683
ADCY1	ENSPCOP00000002207	ENSPCOP00000011503	ENSPCOP00000002207	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.624
ADCY1	ENSPCOP00000002686	ENSPCOP00000011503	ENSPCOP00000002686	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	CSD_1 domain-containing protein.	0.486
ADCY1	ENSPCOP00000007290	ENSPCOP00000011503	ENSPCOP00000007290	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.849
ADCY1	ENSPCOP00000007681	ENSPCOP00000011503	ENSPCOP00000007681	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	EF-hand domain-containing protein.	0.903
ADCY1	ENSPCOP00000008641	ENSPCOP00000011503	ENSPCOP00000008641	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.903