71 items (Propithecus coquereli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GUCY1B1	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (176 aa)
	ENSPCOP00000000307	Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
	PDE1A	Phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family. (424 aa)
	ENSPCOP00000002207	Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (176 aa)
	LOC105823773	Uncharacterized protein. (319 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	PLCB1	Phosphoinositide phospholipase C. (1010 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
	EDN1	Endothelin 1. (193 aa)
	ENSPCOP00000007290	Uncharacterized protein. (174 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	ENSPCOP00000007681	EF-hand domain-containing protein. (132 aa)
	ENSPCOP00000008641	Uncharacterized protein. (715 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (150 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (729 aa)
	ENSPCOP00000010360	AGC-kinase C-terminal domain-containing protein. (86 aa)
	ENSPCOP00000010764	EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
	CLCA4	Chloride channel accessory 4. (791 aa)
	CALM3	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	NPR1	Guanylate cyclase. (1058 aa)
	EDN2	Endothelin 2. (178 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (520 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
	PDE1C	Phosphodiesterase. (769 aa)
	ADRB3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (405 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (138 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	PDE3A	Phosphodiesterase. (1073 aa)
	PVALEF	Parvalbumin like EF-hand containing. (126 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
	CALML4	Calmodulin like 4. (178 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
	CREB1	cAMP responsive element binding protein 1. (280 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	PPP3R1	Uncharacterized protein. (189 aa)
	MINDY4	MINDY lysine 48 deubiquitinase 4. (764 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1544 aa)
	PDE3B	Phosphodiesterase. (1047 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (307 aa)
	ACE	Angiotensin-converting enzyme. (1308 aa)
	ENSPCOP00000024532	Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1286 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1973 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (531 aa)
	CLCA1	Chloride channel accessory 1. (916 aa)
	CLCA2	Chloride channel accessory 2. (943 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	EDN3	Endothelin 3. (224 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
	LOC105813679	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (744 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (484 aa)
	ENSPCOP00000029571	HNOB domain-containing protein. (173 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
	REN	Renin; Belongs to the peptidase A1 family. (405 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
	NPPA	Natriuretic peptide A. (153 aa)
	GNAS	Uncharacterized protein. (394 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	AGT	ENSPCOP00000022959	ENSPCOP00000029301	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.961
ACE	AGTR1	ENSPCOP00000022959	ENSPCOP00000019692	Angiotensin-converting enzyme.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.588
ACE	CALML4	ENSPCOP00000022959	ENSPCOP00000017539	Angiotensin-converting enzyme.	Calmodulin like 4.	0.475
ACE	EDN1	ENSPCOP00000022959	ENSPCOP00000006922	Angiotensin-converting enzyme.	Endothelin 1.	0.449
ACE	ENSPCOP00000007681	ENSPCOP00000022959	ENSPCOP00000007681	Angiotensin-converting enzyme.	EF-hand domain-containing protein.	0.460
ACE	NPPA	ENSPCOP00000022959	ENSPCOP00000030999	Angiotensin-converting enzyme.	Natriuretic peptide A.	0.461
ACE	REN	ENSPCOP00000022959	ENSPCOP00000029905	Angiotensin-converting enzyme.	Renin; Belongs to the peptidase A1 family.	0.590
ADCY5	ADCY6	ENSPCOP00000029755	ENSPCOP00000002439	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.875
ADCY5	ADCYAP1	ENSPCOP00000029755	ENSPCOP00000003954	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase activating polypeptide 1.	0.458
ADCY5	CACNA1C	ENSPCOP00000029755	ENSPCOP00000017234	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.412
ADCY5	CALM1	ENSPCOP00000029755	ENSPCOP00000009692	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.694
ADCY5	CALM2	ENSPCOP00000029755	ENSPCOP00000013912	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.543
ADCY5	CALM3	ENSPCOP00000029755	ENSPCOP00000011445	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.694
ADCY5	CALML4	ENSPCOP00000029755	ENSPCOP00000017539	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.872
ADCY5	ENSPCOP00000000307	ENSPCOP00000029755	ENSPCOP00000000307	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.694
ADCY5	ENSPCOP00000002207	ENSPCOP00000029755	ENSPCOP00000002207	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.543
ADCY5	ENSPCOP00000007290	ENSPCOP00000029755	ENSPCOP00000007290	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.848
ADCY5	ENSPCOP00000007681	ENSPCOP00000029755	ENSPCOP00000007681	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	EF-hand domain-containing protein.	0.832
ADCY5	ENSPCOP00000008641	ENSPCOP00000029755	ENSPCOP00000008641	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.944
ADCY5	ENSPCOP00000010360	ENSPCOP00000029755	ENSPCOP00000010360	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AGC-kinase C-terminal domain-containing protein.	0.424