(66 nodes) Cortisol synthesis and secretion network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GNAS	Uncharacterized protein. (394 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
	LDLR	Low density lipoprotein receptor. (902 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
	KCNK3	Potassium channel subfamily K member. (394 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (484 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (494 aa)
	SP1	Sp1 transcription factor. (788 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
	ENSPCOP00000026475	PDEase domain-containing protein. (163 aa)
	KCNA3	Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (575 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	CREB3	cAMP responsive element binding protein 3. (373 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1973 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
	CACNA1H	Calcium voltage-gated channel subunit alpha1 H. (2221 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (307 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1544 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
	CREB1	cAMP responsive element binding protein 1. (280 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	ATF6B	Activating transcription factor 6 beta. (702 aa)
	CACNA1G	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2381 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
	LOC105827044	Phosphodiesterase 8A; Belongs to the cyclic nucleotide phosphodiesterase family. (748 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	KCNA2	Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (346 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (395 aa)
	CACNA1I	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1991 aa)
	ENSPCOP00000014952	PBC domain-containing protein. (120 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2. (371 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
	ADCY2	Adenylate cyclase 2. (904 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (443 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (468 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
	PLCB1	Phosphoinositide phospholipase C. (1010 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (598 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (461 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
	ENSPCOP00000006909	Uncharacterized protein. (102 aa)
	PBX1	PBX homeobox 1. (430 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (508 aa)
	ENSPCOP00000008641	Uncharacterized protein. (715 aa)
	HSD3B2	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	PBX4	PBX homeobox 4. (374 aa)
	PDE8B	Phosphodiesterase. (885 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (456 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	POMC	Proopiomelanocortin. (258 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSPCOP00000011503	ENSPCOP00000001482	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2.	0.651
ADCY1	ADCY4	ENSPCOP00000011503	ENSPCOP00000011755	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.636
ADCY1	ADCY5	ENSPCOP00000011503	ENSPCOP00000029755	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.634
ADCY1	ADCY6	ENSPCOP00000011503	ENSPCOP00000002439	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.635
ADCY1	ADCY7	ENSPCOP00000011503	ENSPCOP00000024141	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.665
ADCY1	ADCY9	ENSPCOP00000011503	ENSPCOP00000024273	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.819
ADCY1	CACNA1G	ENSPCOP00000011503	ENSPCOP00000017581	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.596
ADCY1	ENSPCOP00000008641	ENSPCOP00000011503	ENSPCOP00000008641	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.903
ADCY1	ENSPCOP00000026475	ENSPCOP00000011503	ENSPCOP00000026475	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDEase domain-containing protein.	0.783
ADCY1	GNAS	ENSPCOP00000011503	ENSPCOP00000031473	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.903
ADCY1	LOC105827044	ENSPCOP00000011503	ENSPCOP00000017167	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase 8A; Belongs to the cyclic nucleotide phosphodiesterase family.	0.783
ADCY1	PDE8B	ENSPCOP00000011503	ENSPCOP00000011274	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.849
ADCY1	POMC	ENSPCOP00000011503	ENSPCOP00000031980	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Proopiomelanocortin.	0.416
ADCY1	PRKACA	ENSPCOP00000011503	ENSPCOP00000028793	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.898
ADCY1	PRKACB	ENSPCOP00000011503	ENSPCOP00000006553	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.898
ADCY1	PTRHD1	ENSPCOP00000011503	ENSPCOP00000000953	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.775
ADCY2	ADCY1	ENSPCOP00000001482	ENSPCOP00000011503	Adenylate cyclase 2.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.651
ADCY2	ADCY4	ENSPCOP00000001482	ENSPCOP00000011755	Adenylate cyclase 2.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.734
ADCY2	ADCY5	ENSPCOP00000001482	ENSPCOP00000029755	Adenylate cyclase 2.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.958
ADCY2	ADCY6	ENSPCOP00000001482	ENSPCOP00000002439	Adenylate cyclase 2.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.970