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ADCY1 ADCY1 IGFBP3 IGFBP3 ENSPCOP00000031725 ENSPCOP00000031725 SHC1 SHC1 MAP2K3 MAP2K3 MAP2K4 MAP2K4 GNAS GNAS MAPK13 MAPK13 PIK3CD PIK3CD PLCB3 PLCB3 STAT3 STAT3 GNAI2 GNAI2 CEP152 CEP152 CRKL CRKL MAPK1 MAPK1 ADCY5 ADCY5 PRKCB PRKCB PRKCA PRKCA AKT1 AKT1 PRKACA PRKACA AKT3 AKT3 MAPK8 MAPK8 GHRL GHRL ENSPCOP00000027781 ENSPCOP00000027781 SOCS3 SOCS3 PLCB4 PLCB4 GHSR GHSR ATF2 ATF2 CREB3L1 CREB3L1 PTK2 PTK2 CREB3 CREB3 MAP2K6 MAP2K6 STAT5B STAT5B CACNA1F CACNA1F ITPR1 ITPR1 PLCG1 PLCG1 ADCY9 ADCY9 ADCY7 ADCY7 GSK3B GSK3B CREB5 CREB5 STAT5A STAT5A MAPK10 MAPK10 CREBBP CREBBP CACNA1S CACNA1S IRS2 IRS2 HRAS HRAS SHC3 SHC3 EP300 EP300 IGF1 IGF1 AKT2 AKT2 CREB1 CREB1 ITPR3 ITPR3 PIK3R1 PIK3R1 PIK3R2 PIK3R2 CRK CRK ATF4 ATF4 ATF6B ATF6B GRB2 GRB2 MAPK14 MAPK14 CACNA1C CACNA1C ADCY3 ADCY3 GHRH GHRH PIK3CB PIK3CB MAP2K1 MAP2K1 CREB3L4 CREB3L4 PIK3CA PIK3CA MAPK11 MAPK11 PLCB2 PLCB2 MAPK12 MAPK12 SHC2 SHC2 CACNA1D CACNA1D CSDE1 CSDE1 CREB3L3 CREB3L3 LOC105822566 LOC105822566 ADCY8 ADCY8 PLCG2 PLCG2 ADCY4 ADCY4 GHRHR GHRHR MAP3K1 MAP3K1 SOS2 SOS2 KRAS KRAS ENSPCOP00000009588 ENSPCOP00000009588 LOC105819868 LOC105819868 SOS1 SOS1 ADCY10 ADCY10 SST SST ENSPCOP00000008641 ENSPCOP00000008641 CREB3L2 CREB3L2 MAPK3 MAPK3 PIK3R3 PIK3R3 STAT1 STAT1 SHC4 SHC4 GNAI1 GNAI1 ENSPCOP00000007290 ENSPCOP00000007290 PRKACB PRKACB SSTR2 SSTR2 PLCB1 PLCB1 NRAS NRAS RAF1 RAF1 JUNB JUNB IGFALS IGFALS GHR GHR SOCS1 SOCS1 ITPR2 ITPR2 ENSPCOP00000002686 ENSPCOP00000002686 POU1F1 POU1F1 ADCY6 ADCY6 MAPK9 MAPK9 PRKCG PRKCG MTOR MTOR ADCY2 ADCY2 MAP2K2 MAP2K2 PTRHD1 PTRHD1 BCAR1 BCAR1 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
IGFBP3Insulin like growth factor binding protein 3. (293 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
SHC1SHC adaptor protein 1. (582 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
GNASUncharacterized protein. (394 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CEP152Centrosomal protein 152. (1655 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
ENSPCOP00000027781Uncharacterized protein. (82 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
STAT5BSignal transducer and activator of transcription. (667 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1973 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
STAT5ASignal transducer and activator of transcription. (805 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CREBBPCREB binding protein. (2449 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1544 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC3SHC adaptor protein 3. (596 aa)
EP300E1A binding protein p300. (2424 aa)
IGF1Insulin like growth factor 1. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
ATF4Activating transcription factor 4. (351 aa)
ATF6BActivating transcription factor 6 beta. (702 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SHC2Uncharacterized protein. (578 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
CSDE1Cold shock domain containing E1. (798 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (456 aa)
LOC105822566Uncharacterized protein. (223 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
KRASUncharacterized protein. (75 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ADCY10Adenylate cyclase 10. (1619 aa)
SSTSomatostatin. (116 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (508 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
SHC4SHC adaptor protein 4. (630 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ENSPCOP00000007290Uncharacterized protein. (174 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (609 aa)
GHRGrowth hormone receptor. (559 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
POU1F1Uncharacterized protein. (170 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
ADCY2Adenylate cyclase 2. (904 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (902 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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