STRINGSTRING
VDAC1 VDAC1 BEAN1 BEAN1 AKT2 AKT2 ADRM1 ADRM1 ITPR3 ITPR3 PIK3R1 PIK3R1 PIK3R2 PIK3R2 PSMD11 PSMD11 GRM1 GRM1 PSMC3 PSMC3 WIPI2 WIPI2 SLC25A5 SLC25A5 PSMD14 PSMD14 PIK3CB PIK3CB PSMD9 PSMD9 LOC105824240 LOC105824240 MAP3K5 MAP3K5 PUM2 PUM2 PIK3CA PIK3CA OPA1 OPA1 TRAF2 TRAF2 PPIF PPIF ATP2A2 ATP2A2 GRIA1 GRIA1 FGF12 FGF12 PLCB2 PLCB2 ENSPCOP00000014399 ENSPCOP00000014399 NRBF2 NRBF2 PSMA3 PSMA3 PSMA6 PSMA6 ATG2B ATG2B ENSPCOP00000013591 ENSPCOP00000013591 ATP2A3 ATP2A3 RYR1 RYR1 C7orf31 C7orf31 PSMD6 PSMD6 FGF14 FGF14 PSMB1 PSMB1 TBPL2 TBPL2 CACNA1A CACNA1A TRPC7 TRPC7 PSMA1 PSMA1 GRIA2 GRIA2 OSBPL2 OSBPL2 PSMA8 PSMA8 ENSPCOP00000009886 ENSPCOP00000009886 GRIA3 GRIA3 AFG3L2 AFG3L2 ENSPCOP00000009588 ENSPCOP00000009588 ATG101 ATG101 ENSPCOP00000008906 ENSPCOP00000008906 TBPL1 TBPL1 KCNC2 KCNC2 PIK3R3 PIK3R3 ENSPCOP00000008176 ENSPCOP00000008176 RBPJ RBPJ PSMB6 PSMB6 ULK2 ULK2 TWNK TWNK ENSPCOP00000006829 ENSPCOP00000006829 PSMD12 PSMD12 PDYN PDYN PSMA4 PSMA4 PLCB1 PLCB1 GRIN3B GRIN3B ATXN1 ATXN1 RB1CC1 RB1CC1 ENSPCOP00000004684 ENSPCOP00000004684 ENSPCOP00000004671 ENSPCOP00000004671 PSMD1 PSMD1 PSMA7 PSMA7 VDAC2 VDAC2 XBP1 XBP1 ITPR2 ITPR2 ENSPCOP00000003641 ENSPCOP00000003641 ATP2A1 ATP2A1 GRIN2D GRIN2D PSMC2 PSMC2 GRIN3A GRIN3A ENSPCOP00000002401 ENSPCOP00000002401 GRIN2A GRIN2A ATXN10 ATXN10 MAPK9 MAPK9 PRKCG PRKCG LOC105810867 LOC105810867 MTOR MTOR KCNC3 KCNC3 PUM1 PUM1 LOC105810841 LOC105810841 PSMD2 PSMD2 CIC CIC ULK1 ULK1 KCNC4 KCNC4 KAT5 KAT5 LOC105815609 LOC105815609 ENSPCOP00000031861 ENSPCOP00000031861 ATG14 ATG14 ENSPCOP00000031317 ENSPCOP00000031317 NFYA NFYA AMBRA1 AMBRA1 MYOD1 MYOD1 KCNC1 KCNC1 SPTBN2 SPTBN2 PIK3CD PIK3CD PLCB3 PLCB3 ATG2A ATG2A SLC25A4 SLC25A4 VDAC3 VDAC3 PSMD7 PSMD7 PRKCB PRKCB PRKCA PRKCA BECN1 BECN1 ENSPCOP00000029247 ENSPCOP00000029247 PSMB7 PSMB7 PSMD4 PSMD4 AKT1 AKT1 RBPJL RBPJL DAB1 DAB1 AKT3 AKT3 ATXN1L ATXN1L MAPK8 MAPK8 VLDLR VLDLR LOC105807375 LOC105807375 GRIN2C GRIN2C PIK3C3 PIK3C3 ENSPCOP00000027105 ENSPCOP00000027105 SP1 SP1 GRIN2B GRIN2B PLCB4 PLCB4 PSMA2 PSMA2 ENSPCOP00000026433 ENSPCOP00000026433 WIPI1 WIPI1 PSMC4 PSMC4 PSMB2 PSMB2 OMA1 OMA1 ITPR1 ITPR1 PSMD13 PSMD13 ATXN2L ATXN2L PSMA5 PSMA5 NOP56 NOP56 RELN RELN MCU MCU SLC25A31 SLC25A31 TBP TBP PSMC5 PSMC5 PIK3R4 PIK3R4 ENSPCOP00000023440 ENSPCOP00000023440 ATG13 ATG13 PSMB4 PSMB4 ENSPCOP00000023228 ENSPCOP00000023228 GTF2B GTF2B ERN1 ERN1 RORA RORA PSMC1 PSMC1 SLC25A6 SLC25A6 MAPK10 MAPK10 PSMB3 PSMB3 SLC1A6 SLC1A6 LOC105815346 LOC105815346 ENSPCOP00000020707 ENSPCOP00000020707 TRPC3 TRPC3 GRIN1 GRIN1 ATXN2 ATXN2 PSMB5 PSMB5 PSMD8 PSMD8 PSMD3 PSMD3 LOC105820642 LOC105820642
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VDAC1Uncharacterized protein. (283 aa)
BEAN1Brain expressed associated with NEDD4 1. (259 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADRM1Adhesion regulating molecule 1. (407 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
GRM1Glutamate metabotropic receptor 1. (1188 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (445 aa)
SLC25A5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (274 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PSMD9PDZ domain-containing protein. (223 aa)
LOC105824240Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (248 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
PUM2Pumilio RNA binding family member 2. (1053 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
FGF12Fibroblast growth factor 12; Belongs to the heparin-binding growth factors family. (208 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
ENSPCOP00000014399Proteasome subunit beta. (212 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMA6Proteasome subunit alpha type. (145 aa)
ATG2BAutophagy related 2B. (2078 aa)
ENSPCOP00000013591Proteasome endopeptidase complex. (228 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1033 aa)
RYR1Ryanodine receptor 1. (4928 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (440 aa)
FGF14Fibroblast growth factor 14; Belongs to the heparin-binding growth factors family. (217 aa)
PSMB1Proteasome subunit beta 1. (232 aa)
TBPL2TATA-box binding protein like 2. (368 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2494 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
PSMA1Proteasome endopeptidase complex. (217 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (857 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (467 aa)
PSMA8Proteasome subunit alpha type. (208 aa)
ENSPCOP00000009886AAA domain-containing protein. (188 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2; Belongs to the AAA ATPase family. (640 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
ATG101Autophagy related 101. (218 aa)
ENSPCOP00000008906PCI domain-containing protein. (387 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
PIK3R3Uncharacterized protein. (454 aa)
ENSPCOP00000008176Proteasome subunit alpha type. (200 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (523 aa)
PSMB6Proteasome subunit beta. (241 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
TWNKTwinkle mtDNA helicase. (669 aa)
ENSPCOP00000006829Uncharacterized protein. (252 aa)
PSMD12PCI domain-containing protein. (480 aa)
PDYNProdynorphin. (256 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1043 aa)
ATXN1Ataxin 1. (791 aa)
RB1CC1RB1 inducible coiled-coil 1. (1590 aa)
ENSPCOP00000004684Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSPCOP00000004671Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (276 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (933 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
VDAC2Voltage dependent anion channel 2. (309 aa)
XBP1BZIP domain-containing protein. (377 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
ENSPCOP00000003641Uncharacterized protein. (213 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1337 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
ENSPCOP00000002401Josephin domain-containing protein. (162 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
ATXN10Ataxin 10. (464 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC105810867Proteasome subunit alpha type. (263 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (773 aa)
PUM1Pumilio RNA binding family member 1. (1189 aa)
LOC105810841Proteasome subunit alpha type. (263 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
CICCapicua transcriptional repressor. (2519 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1045 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (635 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
LOC105815609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
ENSPCOP00000031861Uncharacterized protein. (214 aa)
ATG14Autophagy related 14. (464 aa)
ENSPCOP00000031317Uncharacterized protein. (70 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1270 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
ATG2AAutophagy related 2A. (1931 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
BECN1Beclin 1. (448 aa)
ENSPCOP00000029247Proteasome subunit beta; Belongs to the peptidase T1B family. (257 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
DAB1DAB adaptor protein 1. (588 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ATXN1LAtaxin 1 like. (689 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
VLDLRVery low density lipoprotein receptor. (879 aa)
LOC105807375Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1234 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (734 aa)
ENSPCOP00000027105Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SP1Sp1 transcription factor. (788 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
PSMA2Proteasome subunit alpha type. (245 aa)
ENSPCOP00000026433Uncharacterized protein. (628 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMB2Proteasome subunit beta. (201 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (377 aa)
ATXN2LAtaxin 2 like. (1096 aa)
PSMA5Proteasome subunit alpha type. (128 aa)
NOP56NOP56 ribonucleoprotein. (599 aa)
RELNReelin. (3445 aa)
MCUMitochondrial calcium uniporter. (350 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (270 aa)
TBPTATA-box binding protein. (335 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ENSPCOP00000023440Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSPCOP00000023228Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (935 aa)
RORARAR related orphan receptor A. (532 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (396 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
PSMB3Proteasome subunit beta. (205 aa)
SLC1A6Amino acid transporter. (564 aa)
LOC105815346Pr_beta_C domain-containing protein. (270 aa)
ENSPCOP00000020707Uncharacterized protein. (66 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
ATXN2Ataxin 2. (1275 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
LOC105820642AAA domain-containing protein. (758 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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