(51 nodes) Cocaine addiction network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	MAOA	Amine oxidase. (528 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (306 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (367 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1337 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1043 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
	PDYN	Prodynorphin. (256 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
	LOC105806750	Uncharacterized protein. (261 aa)
	ENSPCOP00000007290	Uncharacterized protein. (174 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	GRM2	Glutamate metabotropic receptor 2. (872 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (961 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (508 aa)
	ENSPCOP00000008641	Uncharacterized protein. (715 aa)
	RGS9	Regulator of G protein signaling 9. (641 aa)
	DDC	Dopa decarboxylase. (480 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (857 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (456 aa)
	GRM3	Glutamate metabotropic receptor 3. (879 aa)
	RGS11	Regulator of G protein signaling 11. (467 aa)
	ENSPCOP00000014002	Uncharacterized protein. (286 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (395 aa)
	DLG4	Uncharacterized protein; Belongs to the MAGUK family. (602 aa)
	ATF6B	Activating transcription factor 6 beta. (702 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	CREB1	cAMP responsive element binding protein 1. (280 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	GPSM1	G protein signaling modulator 1. (697 aa)
	GNAS	Uncharacterized protein. (394 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1234 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	MAOB	Amine oxidase. (528 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (520 aa)
	CREB3	cAMP responsive element binding protein 3. (373 aa)
	TH	Tyrosine hydroxylase. (497 aa)
	SLC18A2	Solute carrier family 18 member A2. (491 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	DRD2	ENSPCOP00000029755	ENSPCOP00000002488	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.408
ADCY5	ENSPCOP00000007290	ENSPCOP00000029755	ENSPCOP00000007290	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.848
ADCY5	ENSPCOP00000008641	ENSPCOP00000029755	ENSPCOP00000008641	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.944
ADCY5	GNAI1	ENSPCOP00000029755	ENSPCOP00000007433	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.848
ADCY5	GNAI2	ENSPCOP00000029755	ENSPCOP00000030255	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.894
ADCY5	GNAS	ENSPCOP00000029755	ENSPCOP00000031473	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.944
ADCY5	PRKACA	ENSPCOP00000029755	ENSPCOP00000028793	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.927
ADCY5	PRKACB	ENSPCOP00000029755	ENSPCOP00000006553	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.940
ATF2	ATF4	ENSPCOP00000026202	ENSPCOP00000018079	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 4.	0.893
ATF2	ATF6B	ENSPCOP00000026202	ENSPCOP00000017869	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Activating transcription factor 6 beta.	0.873
ATF2	CREB1	ENSPCOP00000026202	ENSPCOP00000018701	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 1.	0.948
ATF2	CREB3	ENSPCOP00000026202	ENSPCOP00000025689	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3.	0.874
ATF2	CREB3L1	ENSPCOP00000026202	ENSPCOP00000025987	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 1.	0.852
ATF2	CREB3L2	ENSPCOP00000026202	ENSPCOP00000008368	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 2.	0.855
ATF2	CREB3L3	ENSPCOP00000026202	ENSPCOP00000012548	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 3.	0.856
ATF2	CREB3L4	ENSPCOP00000026202	ENSPCOP00000015909	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	cAMP responsive element binding protein 3 like 4.	0.855
ATF2	CREB5	ENSPCOP00000026202	ENSPCOP00000022351	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.	0.980
ATF2	FOSB	ENSPCOP00000026202	ENSPCOP00000002902	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	FosB proto-oncogene, AP-1 transcription factor subunit.	0.537
ATF2	PRKACA	ENSPCOP00000026202	ENSPCOP00000028793	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.886
ATF2	PRKACB	ENSPCOP00000026202	ENSPCOP00000006553	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.886