STRINGSTRING
NOD1 NOD1 RELA RELA GNAI2 GNAI2 LOC105817025 LOC105817025 MAPK1 MAPK1 IRAK1 IRAK1 C5 C5 IRAK4 IRAK4 MAPK8 MAPK8 TLR4 TLR4 C4BPA C4BPA C4BPB C4BPB TICAM1 TICAM1 C1RL C1RL ENSPCOP00000025645 ENSPCOP00000025645 C1QA C1QA ENSPCOP00000024978 ENSPCOP00000024978 CXCL8 CXCL8 ENSPCOP00000024532 ENSPCOP00000024532 NOS2 NOS2 TIRAP TIRAP C4A C4A ENSPCOP00000022111 ENSPCOP00000022111 MAPK10 MAPK10 CD14 CD14 CFL1 CFL1 C1R C1R SERPING1 SERPING1 CASP7 CASP7 TMED7 TMED7 CASP3 CASP3 CALML4 CALML4 MAPK14 MAPK14 IL12A IL12A TMED3 TMED3 CXCL6 CXCL6 PVALEF PVALEF TNF TNF IRF8 IRF8 CASP1 CASP1 MAPK11 MAPK11 C1S C1S MAPK12 MAPK12 CALM2 CALM2 NLRP3 NLRP3 IL1A IL1A C1QC C1QC C3 C3 IL12B IL12B CALM3 CALM3 LY96 LY96 IL1B IL1B RHOC RHOC ENSPCOP00000010764 ENSPCOP00000010764 CALM1 CALM1 IL23A IL23A EFCAB3 EFCAB3 LOC105819868 LOC105819868 IRF1 IRF1 MAPK3 MAPK3 IL6 IL6 NFKB1 NFKB1 IL10 IL10 ENSPCOP00000007681 ENSPCOP00000007681 GNAI1 GNAI1 ITGB2 ITGB2 ENSPCOP00000007290 ENSPCOP00000007290 ENSPCOP00000006977 ENSPCOP00000006977 RHOA RHOA ITGA5 ITGA5 IRF3 IRF3 CFL2 CFL2 ITGB1 ITGB1 ENSPCOP00000002207 ENSPCOP00000002207 ENSPCOP00000002125 ENSPCOP00000002125 MAPK9 MAPK9 TRAF6 TRAF6 ENSPCOP00000000307 ENSPCOP00000000307 FOS FOS LOC105825461 LOC105825461 MAPK13 MAPK13 MYD88 MYD88 PYCARD PYCARD C1QB C1QB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOD1Nucleotide binding oligomerization domain containing 1. (949 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LOC105817025ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (218 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
C5Complement C5. (1527 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
C4BPAComplement component 4 binding protein alpha. (596 aa)
C4BPBComplement component 4 binding protein beta. (191 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (486 aa)
ENSPCOP00000025645Uncharacterized protein. (162 aa)
C1QAComplement C1q A chain. (245 aa)
ENSPCOP00000024978ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
TIRAPTIR domain containing adaptor protein. (198 aa)
C4AUncharacterized protein. (1742 aa)
ENSPCOP00000022111Uncharacterized protein. (93 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CFL1ADF-H domain-containing protein. (178 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (718 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (491 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (341 aa)
TMED7Transmembrane p24 trafficking protein 7. (224 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CALML4Calmodulin like 4. (178 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
CXCL6C-X-C motif chemokine. (116 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
IRF8Interferon regulatory factor 8. (427 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (254 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (687 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
NLRP3NLR family pyrin domain containing 3. (1036 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
C1QCComplement C1q C chain. (245 aa)
C3Complement C3. (1551 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
LY96Lymphocyte antigen 96. (160 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
RHOCRas homolog family member C. (193 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
EFCAB3Uncharacterized protein. (185 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
IRF1Interferon regulatory factor. (324 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL10Interleukin 10. (178 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ITGB2Integrin beta. (764 aa)
ENSPCOP00000007290Uncharacterized protein. (174 aa)
ENSPCOP00000006977IRF-3 domain-containing protein. (275 aa)
RHOARas homolog family member A. (193 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1041 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (419 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ITGB1Integrin beta. (585 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
ENSPCOP00000002125ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (149 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
TRAF6TNF receptor-associated factor. (498 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
LOC105825461C-type lectin domain-containing protein. (248 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
PYCARDPYD and CARD domain containing. (195 aa)
C1QBComplement C1q B chain. (253 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.