STRINGSTRING
ENSPCOP00000002927 ENSPCOP00000002927 RELA RELA WAS WAS ENSPCOP00000031725 ENSPCOP00000031725 MAP2K3 MAP2K3 MAP2K4 MAP2K4 PYCARD PYCARD ELMO2 ELMO2 IL2 IL2 MYD88 MYD88 MAPK13 MAPK13 ENSPCOP00000030367 ENSPCOP00000030367 PIK3CD PIK3CD CRKL CRKL CD8B CD8B MAPK1 MAPK1 ARHGEF7 ARHGEF7 CHUK CHUK IRAK1 IRAK1 AKT1 AKT1 FYB1 FYB1 IRAK4 IRAK4 AKT3 AKT3 ELMO1 ELMO1 MAPK8 MAPK8 TLR4 TLR4 PTK2B PTK2B IKBKG IKBKG ZAP70 ZAP70 WIPF2 WIPF2 ACTR2 ACTR2 TICAM1 TICAM1 PTK2 PTK2 ENSPCOP00000025645 ENSPCOP00000025645 MAP2K6 MAP2K6 FN1 FN1 CXCL8 CXCL8 PLCG1 PLCG1 WASL WASL ENSPCOP00000024480 ENSPCOP00000024480 ACTR3 ACTR3 GSK3B GSK3B CDC42 CDC42 TAB2 TAB2 PKN1 PKN1 ENSPCOP00000022032 ENSPCOP00000022032 ACTG1 ACTG1 MAPK10 MAPK10 LCP2 LCP2 BAIAP2 BAIAP2 IKBKB IKBKB TAB1 TAB1 VAV3 VAV3 PIP5K1C PIP5K1C AKT2 AKT2 SRC SRC PIK3R1 PIK3R1 PIK3R2 PIK3R2 CRK CRK RPS6KA2 RPS6KA2 MAPK14 MAPK14 RAC1 RAC1 LIMK1 LIMK1 TBK1 TBK1 PIK3CB PIK3CB MAP2K1 MAP2K1 PIK3CA PIK3CA NFATC2 NFATC2 TNF TNF TRAF2 TRAF2 CASP1 CASP1 MAPK11 MAPK11 LAT LAT VAV1 VAV1 LOC105822770 LOC105822770 NFKBIA NFKBIA MAPK12 MAPK12 MEFV MEFV PKN2 PKN2 WASF2 WASF2 RPS6KA1 RPS6KA1 NLRP3 NLRP3 PXN PXN ROCK2 ROCK2 IL1B IL1B RHOC RHOC ARHGEF28 ARHGEF28 GIT2 GIT2 ARHGEF1 ARHGEF1 ACTL8 ACTL8 LCK LCK RAC2 RAC2 LOC105819868 LOC105819868 CD4 CD4 WIPF1 WIPF1 CCL2 CCL2 MAPK3 MAPK3 IL6 IL6 NFKB1 NFKB1 IL10 IL10 PIK3R3 PIK3R3 RPS6KA6 RPS6KA6 VAV2 VAV2 ROCK1 ROCK1 CD8A CD8A ENSPCOP00000006977 ENSPCOP00000006977 RHOA RHOA WIPF3 WIPF3 MAP3K7 MAP3K7 ITGA5 ITGA5 IRF3 IRF3 ACTB ACTB PIP5K1A PIP5K1A RHOG RHOG MAP2K7 MAP2K7 ITGB1 ITGB1 PIP5K1B PIP5K1B MAPK9 MAPK9 NFATC3 NFATC3 ITGA4 ITGA4 RAC3 RAC3 MAP2K2 MAP2K2 NFATC1 NFATC1 TRAF6 TRAF6 BCAR1 BCAR1 ARHGEF12 ARHGEF12 ARF6 ARF6 SKAP2 SKAP2 ACTR3B ACTR3B FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000002927Uncharacterized protein. (160 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
WASWASP actin nucleation promoting factor. (503 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSPCOP00000030367Ig-like domain-containing protein. (214 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CD8BIg-like domain-containing protein. (210 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (782 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FYB1FYN binding protein 1. (826 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
ENSPCOP00000025645Uncharacterized protein. (162 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
FN1Fibronectin 1. (2290 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
CDC42Uncharacterized protein. (191 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PKN1Protein kinase N1. (838 aa)
ENSPCOP00000022032Ig-like domain-containing protein. (95 aa)
ACTG1Actin gamma 1. (404 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
LCP2Lymphocyte cytosolic protein 2. (493 aa)
BAIAP2BAI1 associated protein 2. (544 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (682 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SRCTyrosine-protein kinase. (543 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
RPS6KA2Ribosomal protein S6 kinase. (722 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
RAC1Rac family small GTPase 1. (211 aa)
LIMK1LIM domain kinase 1. (678 aa)
TBK1TANK binding kinase 1. (690 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (254 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
LATLinker for activation of T cells. (236 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
LOC105822770Ig-like domain-containing protein. (140 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MEFVMEFV innate immuity regulator, pyrin. (772 aa)
PKN2Protein kinase N2. (983 aa)
WASF2WASP family member 2. (497 aa)
RPS6KA1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (745 aa)
NLRP3NLR family pyrin domain containing 3. (1036 aa)
PXNPaxillin. (1073 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
RHOCRas homolog family member C. (193 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1702 aa)
GIT2GIT ArfGAP 2. (759 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (967 aa)
ACTL8Actin like 8; Belongs to the actin family. (351 aa)
LCKTyrosine-protein kinase. (417 aa)
RAC2Rac family small GTPase 2. (192 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
CD4CD4 molecule. (452 aa)
WIPF1WH2 domain-containing protein. (509 aa)
CCL2C-C motif chemokine. (99 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL10Interleukin 10. (178 aa)
PIK3R3Uncharacterized protein. (454 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (704 aa)
VAV2Vav guanine nucleotide exchange factor 2. (771 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
CD8ACD8a molecule. (239 aa)
ENSPCOP00000006977IRF-3 domain-containing protein. (275 aa)
RHOARas homolog family member A. (193 aa)
WIPF3WAS/WASL interacting protein family member 3. (394 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1041 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (419 aa)
ACTBActin beta. (378 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (598 aa)
RHOGRas homolog family member G. (191 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ITGB1Integrin beta. (585 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (964 aa)
RAC3Rac family small GTPase 3. (205 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
NFATC1Nuclear factor of activated T cells 1. (945 aa)
TRAF6TNF receptor-associated factor. (498 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (902 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1496 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SKAP2Src kinase associated phosphoprotein 2. (323 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (353 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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