STRINGSTRING
JAK1 JAK1 RELA RELA MYD88 MYD88 MAPK13 MAPK13 MAPK1 MAPK1 ENSPCOP00000029778 ENSPCOP00000029778 PRKCB PRKCB IRAK1 IRAK1 IRAK4 IRAK4 TLR4 TLR4 ENSPCOP00000027517 ENSPCOP00000027517 HLA-DRA HLA-DRA NOS2 NOS2 FOS FOS IFNGR1 IFNGR1 TRAF6 TRAF6 ELK1 ELK1 IFNGR2 IFNGR2 TGFB2 TGFB2 LOC105817206 LOC105817206 ITGA4 ITGA4 CR1 CR1 CYBB CYBB ITGB1 ITGB1 ENSPCOP00000003911 ENSPCOP00000003911 FAM229A FAM229A MAP3K7 MAP3K7 HLA-DOA HLA-DOA HLA-DQB1 HLA-DQB1 TGFB3 TGFB3 LOC105810602 LOC105810602 LOC105810148 LOC105810148 ITGB2 ITGB2 NCF1 NCF1 HLA-DPA1 HLA-DPA1 STAT1 STAT1 NCF2 NCF2 IL10 IL10 NFKB1 NFKB1 MAPK3 MAPK3 PTGS2 PTGS2 ENSPCOP00000009238 ENSPCOP00000009238 LOC105819868 LOC105819868 ENSPCOP00000009427 ENSPCOP00000009427 LOC105821782 LOC105821782 NFKBIB NFKBIB IL1B IL1B IL12B IL12B C3 C3 ENSPCOP00000012847 ENSPCOP00000012847 EEF1A2 EEF1A2 IL1A IL1A PTPN6 PTPN6 LOC105819867 LOC105819867 MAPK12 MAPK12 NFKBIA NFKBIA NCF4 NCF4 LOC105825403 LOC105825403 LOC105824388 LOC105824388 LOC105822770 LOC105822770 MAPK11 MAPK11 TNF TNF LOC105817207 LOC105817207 IL12A IL12A MAPK14 MAPK14 IL4 IL4 ENSPCOP00000018448 ENSPCOP00000018448 MARCKSL1 MARCKSL1 HLA-DMA HLA-DMA HLA-DOB HLA-DOB IFNG IFNG TAB1 TAB1 LOC105817835 LOC105817835 ENSPCOP00000022032 ENSPCOP00000022032 TAB2 TAB2 TGFB1 TGFB1 CYBA CYBA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1153 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSPCOP00000029778Tr-type G domain-containing protein. (64 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
ENSPCOP00000027517Uncharacterized protein. (196 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
IFNGR1Interferon gamma receptor 1. (479 aa)
TRAF6TNF receptor-associated factor. (498 aa)
ELK1ETS transcription factor ELK1. (430 aa)
IFNGR2Interferon gamma receptor 2. (304 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC105817206Tr-type G domain-containing protein. (446 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (964 aa)
CR1Uncharacterized protein. (1529 aa)
CYBBCytochrome b-245 beta chain. (533 aa)
ITGB1Integrin beta. (585 aa)
ENSPCOP00000003911Tr-type G domain-containing protein. (67 aa)
FAM229AFamily with sequence similarity 229 member A. (128 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC105810602Tr-type G domain-containing protein. (399 aa)
LOC105810148Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ITGB2Integrin beta. (764 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
IL10Interleukin 10. (178 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ENSPCOP00000009238Tr-type G domain-containing protein. (65 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
ENSPCOP00000009427Uncharacterized protein. (189 aa)
LOC105821782Uncharacterized protein. (380 aa)
NFKBIBNFKB inhibitor beta. (346 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
C3Complement C3. (1551 aa)
ENSPCOP00000012847IG domain-containing protein. (167 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (458 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
LOC105819867Tr-type G domain-containing protein. (408 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NCF4Neutrophil cytosolic factor 4. (306 aa)
LOC105825403Tr-type G domain-containing protein. (446 aa)
LOC105824388Ig-like domain-containing protein. (264 aa)
LOC105822770Ig-like domain-containing protein. (140 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
LOC105817207Tr-type G domain-containing protein. (446 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ENSPCOP00000018448Uncharacterized protein. (87 aa)
MARCKSL1Uncharacterized protein. (200 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (261 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LOC105817835MHC_II_beta domain-containing protein. (175 aa)
ENSPCOP00000022032Ig-like domain-containing protein. (95 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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