STRINGSTRING
MAPK1 MAPK1 CHUK CHUK IRAK1 IRAK1 CALR CALR AKT1 AKT1 IRAK4 IRAK4 AKT3 AKT3 MAPK8 MAPK8 TLR4 TLR4 TNFRSF1A TNFRSF1A IKBKG IKBKG PLCB4 PLCB4 TICAM1 TICAM1 FASLG FASLG PPP2CA PPP2CA C1QA C1QA GNAQ GNAQ CXCL8 CXCL8 GNA11 GNA11 GNA14 GNA14 NOS2 NOS2 TGFBR2 TGFBR2 TGFB2 TGFB2 FAS FAS AADACL2 AADACL2 IFNGR2 IFNGR2 TRAF6 TRAF6 SMAD2 SMAD2 IFNGR1 IFNGR1 FOS FOS BDKRB2 BDKRB2 PPP2R2C PPP2R2C PIK3R3 PIK3R3 IL10 IL10 NFKB1 NFKB1 IL6 IL6 MAPK3 MAPK3 ENSPCOP00000008641 ENSPCOP00000008641 CCL2 CCL2 LOC105819868 LOC105819868 SERPINE1 SERPINE1 IL1B IL1B CD3E CD3E CASP8 CASP8 TGFB1 TGFB1 MAPK9 MAPK9 ENSPCOP00000002561 ENSPCOP00000002561 CCL5 CCL5 GNAI1 GNAI1 PPP2R1A PPP2R1A CFLAR CFLAR KNG1 KNG1 PPP2R2B PPP2R2B CD3D CD3D PLCB1 PLCB1 GNA15 GNA15 PPP2CB PPP2CB TLR9 TLR9 TGFB3 TGFB3 ENSPCOP00000007290 ENSPCOP00000007290 ADCY1 ADCY1 LOC105813852 LOC105813852 IL12B IL12B C3 C3 C1QC C1QC ENSPCOP00000013862 ENSPCOP00000013862 MAPK12 MAPK12 NFKBIA NFKBIA PLCB2 PLCB2 MAPK11 MAPK11 PPP2R2D PPP2R2D TNF TNF PIK3CA PIK3CA IL12A IL12A CD247 CD247 PIK3CB PIK3CB CD3G CD3G MAPK14 MAPK14 PIK3R2 PIK3R2 TGFBR1 TGFBR1 PIK3R1 PIK3R1 AKT2 AKT2 PPP2R1B PPP2R1B IFNG IFNG IKBKB IKBKB FADD FADD ACE ACE MAPK10 MAPK10 GNAL GNAL PPP2R2A PPP2R2A RELA RELA C1QB C1QB ENSPCOP00000031725 ENSPCOP00000031725 MAP2K4 MAP2K4 GNAS GNAS IL2 IL2 MYD88 MYD88 GNAO1 GNAO1 MAPK13 MAPK13 ENSPCOP00000030367 ENSPCOP00000030367 PIK3CD PIK3CD PLCB3 PLCB3 GNAI2 GNAI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
CALRCalreticulin. (417 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (278 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
C1QAComplement C1q A chain. (245 aa)
GNAQG protein subunit alpha q. (359 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
GNA11G protein subunit alpha 11. (313 aa)
GNA14G protein subunit alpha 14. (355 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FASFas cell surface death receptor. (309 aa)
AADACL2Arylacetamide deacetylase like 2. (377 aa)
IFNGR2Interferon gamma receptor 2. (304 aa)
TRAF6TNF receptor-associated factor. (498 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
IFNGR1Interferon gamma receptor 1. (479 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PIK3R3Uncharacterized protein. (454 aa)
IL10Interleukin 10. (178 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL6Uncharacterized protein. (211 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
CCL2C-C motif chemokine. (99 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CD3ECD3e molecule. (187 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
ENSPCOP00000002561Uncharacterized protein. (546 aa)
CCL5C-C motif chemokine. (91 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (333 aa)
KNG1Uncharacterized protein. (391 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CD3DUncharacterized protein. (97 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
GNA15G protein subunit alpha 15. (374 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TLR9TIR domain-containing protein. (1029 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSPCOP00000007290Uncharacterized protein. (174 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
LOC105813852C-C motif chemokine. (94 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
C3Complement C3. (1551 aa)
C1QCComplement C1q C chain. (245 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
CD247CD247 molecule. (164 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CD3GCD3g molecule. (182 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
PIK3R2Uncharacterized protein. (726 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (552 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
ACEAngiotensin-converting enzyme. (1308 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
GNALG protein subunit alpha L. (454 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (384 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
C1QBComplement C1q B chain. (253 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
GNASUncharacterized protein. (394 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
GNAO1G protein subunit alpha o1. (354 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSPCOP00000030367Ig-like domain-containing protein. (214 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
GNAI2G protein subunit alpha i2. (355 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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