(45 nodes) African trypanosomiasis network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPCOP00000009588	Uncharacterized protein. (316 aa)
	HBQ1	Hemoglobin subunit theta 1; Belongs to the globin family. (144 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	NPPA	Natriuretic peptide A. (153 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (353 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	PRKCA	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
	HBA1	GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
	THOP1	Thimet oligopeptidase 1. (687 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (278 aa)
	APOL6	Apolipoprotein L6. (308 aa)
	HP	Uncharacterized protein; Belongs to the peptidase S1 family. (347 aa)
	ENSPCOP00000024480	Uncharacterized protein. (103 aa)
	NGB	Neuroglobin; Belongs to the globin family. (151 aa)
	ENSPCOP00000022032	Ig-like domain-containing protein. (95 aa)
	HBM	Hemoglobin subunit mu; Belongs to the globin family. (141 aa)
	ENSPCOP00000021000	GLOBIN domain-containing protein; Belongs to the globin family. (145 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	ICAM1	Intercellular adhesion molecule 1. (533 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	IL6	Uncharacterized protein. (211 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
	LOC105822770	Ig-like domain-containing protein. (140 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
	LAMA4	Laminin subunit alpha 4. (1816 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (425 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	AADACL2	Arylacetamide deacetylase like 2. (377 aa)
	FAS	Fas cell surface death receptor. (309 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	APOA1	Apolipoprotein A1. (265 aa)
	LOC105822074	GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
	KNG1	Uncharacterized protein. (391 aa)
	LOC105822072	GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (407 aa)
	PLCB1	Phosphoinositide phospholipase C. (1010 aa)
	HBE1	Hemoglobin subunit epsilon 1; Belongs to the globin family. (147 aa)
	TLR9	TIR domain-containing protein. (1029 aa)
	SELE	Selectin E. (610 aa)
	CYGB	Cytoglobin; Belongs to the globin family. (219 aa)
	IL10	Interleukin 10. (178 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADACL2	HP	ENSPCOP00000001231	ENSPCOP00000025174	Arylacetamide deacetylase like 2.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.406
AADACL2	IDO1	ENSPCOP00000001231	ENSPCOP00000005533	Arylacetamide deacetylase like 2.	Indoleamine 2,3-dioxygenase 1.	0.556
AADACL2	IDO2	ENSPCOP00000001231	ENSPCOP00000009591	Arylacetamide deacetylase like 2.	Indoleamine 2,3-dioxygenase 2.	0.576
AADACL2	PLCB1	ENSPCOP00000001231	ENSPCOP00000005605	Arylacetamide deacetylase like 2.	Phosphoinositide phospholipase C.	0.466
AADACL2	PLCB2	ENSPCOP00000001231	ENSPCOP00000014485	Arylacetamide deacetylase like 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.462
AADACL2	PLCB3	ENSPCOP00000001231	ENSPCOP00000030275	Arylacetamide deacetylase like 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.461
AADACL2	PLCB4	ENSPCOP00000001231	ENSPCOP00000026795	Arylacetamide deacetylase like 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.432
AADACL2	THOP1	ENSPCOP00000001231	ENSPCOP00000027009	Arylacetamide deacetylase like 2.	Thimet oligopeptidase 1.	0.713
APOL6	ENSPCOP00000021000	ENSPCOP00000025424	ENSPCOP00000021000	Apolipoprotein L6.	GLOBIN domain-containing protein; Belongs to the globin family.	0.444
APOL6	HBA1	ENSPCOP00000025424	ENSPCOP00000028742	Apolipoprotein L6.	GLOBIN domain-containing protein; Belongs to the globin family.	0.444
APOL6	HBM	ENSPCOP00000025424	ENSPCOP00000021810	Apolipoprotein L6.	Hemoglobin subunit mu; Belongs to the globin family.	0.444
APOL6	HBQ1	ENSPCOP00000025424	ENSPCOP00000010892	Apolipoprotein L6.	Hemoglobin subunit theta 1; Belongs to the globin family.	0.444
APOL6	HP	ENSPCOP00000025424	ENSPCOP00000025174	Apolipoprotein L6.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.691
CYGB	HP	ENSPCOP00000007778	ENSPCOP00000025174	Cytoglobin; Belongs to the globin family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.440
CYGB	MB	ENSPCOP00000007778	ENSPCOP00000000934	Cytoglobin; Belongs to the globin family.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.525
CYGB	NGB	ENSPCOP00000007778	ENSPCOP00000022547	Cytoglobin; Belongs to the globin family.	Neuroglobin; Belongs to the globin family.	0.596
ENSPCOP00000009588	PLCB1	ENSPCOP00000009588	ENSPCOP00000005605	Uncharacterized protein.	Phosphoinositide phospholipase C.	0.790
ENSPCOP00000009588	PLCB2	ENSPCOP00000009588	ENSPCOP00000014485	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.796
ENSPCOP00000009588	PLCB3	ENSPCOP00000009588	ENSPCOP00000030275	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.798
ENSPCOP00000009588	PLCB4	ENSPCOP00000009588	ENSPCOP00000026795	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.800