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| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | STAT3 | Signal transducer and activator of transcription. (796 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | RASSF1 | Ras association domain family member 1. (349 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | GLS | Glutaminase. (554 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (162 aa) |
| | EFNA3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa) |
| | SHC1 | SHC adaptor protein 1. (582 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | CEP152 | Centrosomal protein 152. (1655 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PRKCA | Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa) |
| | NOTCH4 | Notch receptor 4. (2000 aa) |
| | APC | APC regulator of WNT signaling pathway. (2844 aa) |
| | FSCN2 | Fascin. (491 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1252 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (807 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1337 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (314 aa) |
| | PLAU | Plasminogen activator, urokinase. (432 aa) |
| | CD44 | CD44 molecule (Indian blood group). (746 aa) |
| | CDK6 | Cyclin dependent kinase 6. (263 aa) |
| | CDKN2A | Cyclin dependent kinase inhibitor 2A. (152 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | PDGFRA | Platelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (855 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (629 aa) |
| | ENSPCOP00000025645 | Uncharacterized protein. (162 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | ADAM15 | ADAM metallopeptidase domain 15. (859 aa) |
| | ENSPCOP00000024796 | Uncharacterized protein. (442 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | THBS1 | Thrombospondin 1. (1185 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa) |
| | BCL2L11 | BCL2 like 11. (200 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | VEGFA | Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa) |
| | CDC25B | Cell division cycle 25B. (578 aa) |
| | ENSPCOP00000023392 | Uncharacterized protein. (157 aa) |
| | KIF23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (960 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2300 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa) |
| | HOXD10 | Homeobox D10. (340 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | MET | MET proto-oncogene, receptor tyrosine kinase. (1397 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | ST14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa) |
| | LOC105826415 | Uncharacterized protein. (820 aa) |
| | CREBBP | CREB binding protein. (2449 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (747 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1258 aa) |
| | BCL2 | BCL2 apoptosis regulator. (234 aa) |
| | UBE2I | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | BMI1 | RING-type domain-containing protein. (326 aa) |
| | TNXB | Uncharacterized protein. (3508 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1002 aa) |
| | TNN | Tenascin N. (1299 aa) |
| | EP300 | E1A binding protein p300. (2424 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (230 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PDCD4 | Programmed cell death 4. (450 aa) |
| | PIK3R2 | Uncharacterized protein. (726 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | RECK | Reversion inducing cysteine rich protein with kazal motifs. (969 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1. (377 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa) |
| | PIK3CA | Phosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa) |
| | EFNA4 | Ephrin A4; Belongs to the ephrin family. (201 aa) |
| | EFNA1 | Ephrin A1; Belongs to the ephrin family. (205 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | ZFPM2 | Zinc finger protein, FOG family member 2. (1151 aa) |
| | GLS2 | Glutaminase 2. (598 aa) |
| | EFNA2 | Ephrin A2; Belongs to the ephrin family. (211 aa) |
| | LOC105812777 | Uncharacterized protein. (436 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1615 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | CSDE1 | Cold shock domain containing E1. (798 aa) |
| | ENSPCOP00000012342 | RING-type domain-containing protein. (80 aa) |
| | CDCA5 | Cell division cycle associated 5. (274 aa) |
| | MMP9 | Matrix metallopeptidase 9. (709 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (553 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa) |
| | FOXP1 | Forkhead box P1. (693 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | CCNG1 | Cyclin G1. (151 aa) |
| | GPSM3 | G protein signaling modulator 3. (160 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K. (464 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1281 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa) |
| | ENSPCOP00000009641 | Uncharacterized protein. (136 aa) |
| | KRAS | Uncharacterized protein. (75 aa) |
| | ENSPCOP00000009588 | Uncharacterized protein. (316 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | CDC25C | Cell division cycle 25C. (454 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | TNC | Uncharacterized protein. (2138 aa) |
| | E2F3 | E2F transcription factor 3. (464 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (401 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (961 aa) |
| | PIK3R3 | Uncharacterized protein. (454 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | ROCK1 | Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | LOC105812775 | SWIB domain-containing protein. (243 aa) |
| | FSCN1 | Fascin. (493 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (375 aa) |
| | CDC25A | Cell division cycle 25A. (527 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (588 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1041 aa) |
| | SOX12 | Transcription factor SOX. (314 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1504 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | NOTCH3 | Notch receptor 3. (2318 aa) |
| | ENSPCOP00000004787 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa) |
| | NOTCH1 | Notch receptor 1. (2420 aa) |
| | ENSPCOP00000004497 | Uncharacterized protein. (280 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase A5. (643 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (223 aa) |
| | LOC105806826 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | MARCKS | Myristoylated alanine rich protein kinase C substrate. (334 aa) |
| | ENSPCOP00000002686 | CSD_1 domain-containing protein. (293 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (577 aa) |
| | LOC105822640 | Integrin beta; Belongs to the integrin beta chain family. (454 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | MMP16 | Matrix metallopeptidase 16. (587 aa) |
| | TRIM71 | Tripartite motif containing 71. (868 aa) |
| | EZR | Ezrin. (586 aa) |
| | E2F2 | E2F transcription factor 2. (435 aa) |
| | SOX4 | Transcription factor SOX. (479 aa) |
| | HMGA2 | Uncharacterized protein. (117 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
