STRINGSTRING
MSH2 MSH2 LOC105815609 LOC105815609 TP53 TP53 TCF7 TCF7 RPS6KB1 RPS6KB1 PPP1R14B PPP1R14B BAD BAD PIK3CD PIK3CD AXIN1 AXIN1 MAPK1 MAPK1 TCF7L1 TCF7L1 POLK POLK CCND1 CCND1 CASP9 CASP9 RALB RALB AKT1 AKT1 APC APC AKT3 AKT3 MAPK8 MAPK8 ENSPCOP00000028080 ENSPCOP00000028080 LOC105807375 LOC105807375 ENSPCOP00000027105 ENSPCOP00000027105 ENSPCOP00000025645 ENSPCOP00000025645 SMAD4 SMAD4 BRAF BRAF BCL2L11 BCL2L11 ENSPCOP00000024116 ENSPCOP00000024116 ENSPCOP00000023440 ENSPCOP00000023440 ENSPCOP00000023228 ENSPCOP00000023228 APC2 APC2 EREG EREG TGFB1 TGFB1 GSK3B GSK3B CTNNB1 CTNNB1 GADD45A GADD45A MAPK10 MAPK10 SMAD3 SMAD3 BCL2 BCL2 DDB2 DDB2 GADD45G GADD45G BIRC5 BIRC5 HRAS HRAS BAX BAX AKT2 AKT2 TGFBR1 TGFBR1 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR GRB2 GRB2 CASP3 CASP3 RAC1 RAC1 MSH3 MSH3 BAK1 BAK1 PIK3CB PIK3CB BBC3 BBC3 EPGN EPGN MAP2K1 MAP2K1 PIK3CA PIK3CA RALGDS RALGDS ENSPCOP00000015102 ENSPCOP00000015102 EGF EGF RPS6KB2 RPS6KB2 RALA RALA C7orf31 C7orf31 CSDE1 CSDE1 TCF7L2 TCF7L2 ARAF ARAF RHOC RHOC SOS2 SOS2 KRAS KRAS RAC2 RAC2 APPL1 APPL1 SOS1 SOS1 MAPK3 MAPK3 PIK3R3 PIK3R3 AXIN2 AXIN2 MSH6 MSH6 TGFA TGFA TGFB3 TGFB3 RHOA RHOA NRAS NRAS RAF1 RAF1 GADD45B GADD45B AREG AREG ENSPCOP00000004684 ENSPCOP00000004684 LEF1 LEF1 MLH1 MLH1 MYC MYC PMAIP1 PMAIP1 ENSPCOP00000002686 ENSPCOP00000002686 MAPK9 MAPK9 MTOR MTOR RAC3 RAC3 MAP2K2 MAP2K2 TGFBR2 TGFBR2 TGFB2 TGFB2 SMAD2 SMAD2 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa)
LOC105815609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
TCF7Transcription factor 7. (303 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PPP1R14BUncharacterized protein. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AXIN1Axin 1. (865 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
POLKDNA polymerase kappa. (832 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
RALBRAS like proto-oncogene B. (212 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
ENSPCOP00000028080Uncharacterized protein. (597 aa)
LOC105807375Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSPCOP00000027105Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSPCOP00000025645Uncharacterized protein. (162 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
BCL2L11BCL2 like 11. (200 aa)
ENSPCOP00000024116Uncharacterized protein. (120 aa)
ENSPCOP00000023440Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
ENSPCOP00000023228Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
APC2APC regulator of WNT signaling pathway 2. (2300 aa)
EREGEpiregulin. (166 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
RAC1Rac family small GTPase 1. (211 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1091 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
BBC3BCL2 binding component 3. (260 aa)
EPGNEpithelial mitogen. (153 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
RALGDSUncharacterized protein. (912 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
EGFEpidermal growth factor. (1132 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
RALARAS like proto-oncogene A. (206 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
CSDE1Cold shock domain containing E1. (798 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
RHOCRas homolog family member C. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
KRASUncharacterized protein. (75 aa)
RAC2Rac family small GTPase 2. (192 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (661 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
AXIN2Axin 2. (716 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1229 aa)
TGFATransforming growth factor alpha. (190 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RHOARas homolog family member A. (193 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
AREGAmphiregulin. (253 aa)
ENSPCOP00000004684Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
MLH1MutL homolog 1. (757 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
PMAIP1Uncharacterized protein. (54 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
RAC3Rac family small GTPase 3. (205 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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