STRINGSTRING
SMAD3 SMAD3 IKBKB IKBKB BCL2L1 BCL2L1 DDB2 DDB2 GADD45G GADD45G BAX BAX AKT2 AKT2 TGFBR1 TGFBR1 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR E2F1 E2F1 RAC1 RAC1 BAK1 BAK1 PIK3CB PIK3CB MAP2K1 MAP2K1 PIK3CA PIK3CA RALGDS RALGDS ENSPCOP00000015102 ENSPCOP00000015102 EGF EGF RPS6KB2 RPS6KB2 JAK1 JAK1 RALA RALA ARAF ARAF RB1 RB1 RAC2 RAC2 E2F3 E2F3 MAPK3 MAPK3 NFKB1 NFKB1 BRCA2 BRCA2 PIK3R3 PIK3R3 STAT1 STAT1 RAD51 RAD51 TGFA TGFA TGFB3 TGFB3 RAF1 RAF1 GADD45B GADD45B ENSPCOP00000002927 ENSPCOP00000002927 MAPK9 MAPK9 CDK4 CDK4 MTOR MTOR RAC3 RAC3 RALBP1 RALBP1 TGFBR2 TGFBR2 PLD2 PLD2 TGFB2 TGFB2 E2F2 E2F2 SMAD2 SMAD2 PLD1 PLD1 ARHGEF6 ARHGEF6 MAPK10 MAPK10 CDC42 CDC42 GADD45A GADD45A TGFB1 TGFB1 VEGFA VEGFA BRAF BRAF SMAD4 SMAD4 CDKN2A CDKN2A CDK6 CDK6 IKBKG IKBKG ERBB2 ERBB2 MAPK8 MAPK8 AKT3 AKT3 AKT1 AKT1 RALB RALB CASP9 CASP9 CCND1 CCND1 CHUK CHUK POLK POLK MAPK1 MAPK1 STAT3 STAT3 PIK3CD PIK3CD BAD BAD PPP1R14B PPP1R14B RPS6KB1 RPS6KB1 TP53 TP53 RELA RELA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (443 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
BCL2L1BCL2 like 1. (233 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F1E2F transcription factor 1. (436 aa)
RAC1Rac family small GTPase 1. (211 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
RALGDSUncharacterized protein. (912 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
EGFEpidermal growth factor. (1132 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
RALARAS like proto-oncogene A. (206 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
RB1RB transcriptional corepressor 1. (787 aa)
RAC2Rac family small GTPase 2. (192 aa)
E2F3E2F transcription factor 3. (464 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
PIK3R3Uncharacterized protein. (454 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (340 aa)
TGFATransforming growth factor alpha. (190 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
RAC3Rac family small GTPase 3. (205 aa)
RALBP1RalA binding protein 1. (655 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PLD2Phospholipase. (932 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
E2F2E2F transcription factor 2. (435 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
PLD1Phospholipase. (1040 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CDC42Uncharacterized protein. (191 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RALBRAS like proto-oncogene B. (212 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
POLKDNA polymerase kappa. (832 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BUncharacterized protein. (147 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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