STRINGSTRING
GRB2 GRB2 TP53 TP53 TCF7 TCF7 PPP1R14B PPP1R14B BAD BAD CTNNA1 CTNNA1 PIK3CD PIK3CD AXIN1 AXIN1 MAPK1 MAPK1 TCF7L1 TCF7L1 POLK POLK CCND1 CCND1 CASP9 CASP9 AKT1 AKT1 APC APC AKT3 AKT3 ERBB2 ERBB2 FOXO3 FOXO3 ENSPCOP00000024796 ENSPCOP00000024796 BRAF BRAF APC2 APC2 GSK3B GSK3B CTNNB1 CTNNB1 GADD45A GADD45A CTNNA3 CTNNA3 DDB2 DDB2 GADD45G GADD45G HRAS HRAS BAX BAX AKT2 AKT2 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR BAK1 BAK1 PIK3CB PIK3CB MAP2K1 MAP2K1 PIK3CA PIK3CA ENSPCOP00000015102 ENSPCOP00000015102 ILK ILK EGF EGF CTNNA2 CTNNA2 CSDE1 CSDE1 TCF7L2 TCF7L2 ARAF ARAF SOS2 SOS2 KRAS KRAS SOS1 SOS1 CDH1 CDH1 MAPK3 MAPK3 PIK3R3 PIK3R3 AXIN2 AXIN2 NRAS NRAS RAF1 RAF1 GADD45B GADD45B PDPK1 PDPK1 LEF1 LEF1 MLH1 MLH1 MYC MYC ENSPCOP00000002686 ENSPCOP00000002686 PTEN PTEN MAP2K2 MAP2K2 ELK1 ELK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB2Growth factor receptor bound protein 2. (217 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
TCF7Transcription factor 7. (303 aa)
PPP1R14BUncharacterized protein. (147 aa)
BADBCL2 associated agonist of cell death. (168 aa)
CTNNA1Catenin alpha 1. (906 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
AXIN1Axin 1. (865 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
POLKDNA polymerase kappa. (832 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FOXO3Forkhead box O3. (672 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
APC2APC regulator of WNT signaling pathway 2. (2300 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CTNNA3Catenin alpha 3. (783 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
ILKIntegrin linked kinase. (518 aa)
EGFEpidermal growth factor. (1132 aa)
CTNNA2Catenin alpha 2. (822 aa)
CSDE1Cold shock domain containing E1. (798 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
KRASUncharacterized protein. (75 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (904 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
AXIN2Axin 2. (716 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
MLH1MutL homolog 1. (757 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ELK1ETS transcription factor ELK1. (430 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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