STRINGSTRING
PIK3CD PIK3CD CEP152 CEP152 MAPK1 MAPK1 POLK POLK CCND1 CCND1 PRKCB PRKCB PRKCA PRKCA AKT1 AKT1 AKT3 AKT3 CAMK1G CAMK1G CDK6 CDK6 CDKN2A CDKN2A PDGFRA PDGFRA CAMK2A CAMK2A ENSPCOP00000024796 ENSPCOP00000024796 PDGFA PDGFA PLCG1 PLCG1 BRAF BRAF ENSPCOP00000024532 ENSPCOP00000024532 CAMK2G CAMK2G GADD45A GADD45A IGF1R IGF1R CAMK2D CAMK2D DDB2 DDB2 GADD45G GADD45G HRAS HRAS BAX BAX SHC3 SHC3 IGF1 IGF1 AKT2 AKT2 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR E2F1 E2F1 GRB2 GRB2 CALML4 CALML4 BAK1 BAK1 PIK3CB PIK3CB MAP2K1 MAP2K1 CAMK1D CAMK1D PIK3CA PIK3CA PVALEF PVALEF EGF EGF CALM2 CALM2 SHC2 SHC2 LOC105812777 LOC105812777 CSDE1 CSDE1 PLCG2 PLCG2 CALM3 CALM3 ARAF ARAF RB1 RB1 ENSPCOP00000010764 ENSPCOP00000010764 SOS2 SOS2 CALM1 CALM1 KRAS KRAS ENSPCOP00000009588 ENSPCOP00000009588 SOS1 SOS1 E2F3 E2F3 MAPK3 MAPK3 PIK3R3 PIK3R3 SHC4 SHC4 ENSPCOP00000007681 ENSPCOP00000007681 LOC105812775 LOC105812775 CAMK2B CAMK2B TGFA TGFA NRAS NRAS RAF1 RAF1 GADD45B GADD45B PDGFB PDGFB ENSPCOP00000002686 ENSPCOP00000002686 CAMK1 CAMK1 ARSI ARSI ENSPCOP00000002207 ENSPCOP00000002207 PRKCG PRKCG CDK4 CDK4 MTOR MTOR PTEN PTEN MAP2K2 MAP2K2 E2F2 E2F2 ENSPCOP00000000307 ENSPCOP00000000307 PDGFRB PDGFRB CAMK4 CAMK4 SHC1 SHC1 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CEP152Centrosomal protein 152. (1655 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
POLKDNA polymerase kappa. (832 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (600 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (503 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
SHC3SHC adaptor protein 3. (596 aa)
IGF1Insulin like growth factor 1. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F1E2F transcription factor 1. (436 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CALML4Calmodulin like 4. (178 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
EGFEpidermal growth factor. (1132 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
SHC2Uncharacterized protein. (578 aa)
LOC105812777Uncharacterized protein. (436 aa)
CSDE1Cold shock domain containing E1. (798 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
RB1RB transcriptional corepressor 1. (787 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
KRASUncharacterized protein. (75 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
E2F3E2F transcription factor 3. (464 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
SHC4SHC adaptor protein 4. (630 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (665 aa)
TGFATransforming growth factor alpha. (190 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
CAMK1Calcium/calmodulin dependent protein kinase I. (326 aa)
ARSIArylsulfatase family member I. (572 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
E2F2E2F transcription factor 2. (435 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
SHC1SHC adaptor protein 1. (582 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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