STRINGSTRING
ENSPCOP00000028106 ENSPCOP00000028106 BRAF BRAF ENSPCOP00000024531 ENSPCOP00000024531 RET RET CTNNB1 CTNNB1 GADD45A GADD45A DDB2 DDB2 RXRG RXRG GADD45G GADD45G HRAS HRAS BAX BAX CCDC6 CCDC6 BAK1 BAK1 PAX8 PAX8 MAP2K1 MAP2K1 CSDE1 CSDE1 TCF7L2 TCF7L2 PPARG PPARG NTRK1 NTRK1 KRAS KRAS TPR TPR CDH1 CDH1 MAPK3 MAPK3 RXRB RXRB RXRA RXRA NRAS NRAS TFG TFG GADD45B GADD45B LEF1 LEF1 TCF7 TCF7 MYC MYC NCOA4 NCOA4 LOC105823488 LOC105823488 ENSPCOP00000002686 ENSPCOP00000002686 ENSPCOP00000002382 ENSPCOP00000002382 MAP2K2 MAP2K2 TP53 TP53 POLK POLK TCF7L1 TCF7L1 MAPK1 MAPK1 CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000028106Uncharacterized protein. (202 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
ENSPCOP00000024531Uncharacterized protein. (204 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
CTNNB1Catenin beta 1. (781 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
RXRGRetinoid X receptor gamma. (463 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
CCDC6Coiled-coil domain containing 6. (474 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
PAX8Paired box 8. (458 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
CSDE1Cold shock domain containing E1. (798 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (502 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
KRASUncharacterized protein. (75 aa)
TPRTPR_MLP1_2 domain-containing protein. (2357 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (904 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
RXRBRetinoid X receptor beta. (535 aa)
RXRARetinoid X receptor alpha. (469 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TFGTrafficking from ER to golgi regulator. (401 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
TCF7Transcription factor 7. (303 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
NCOA4Nuclear receptor coactivator 4. (650 aa)
LOC105823488Uncharacterized protein; Belongs to the tropomyosin family. (234 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ENSPCOP00000002382Uncharacterized protein. (398 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
POLKDNA polymerase kappa. (832 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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