STRINGSTRING
GLI2 GLI2 WNT2B WNT2B GLI3 GLI3 WNT7B WNT7B WNT10B WNT10B WNT7A WNT7A FZD9 FZD9 FZD5 FZD5 LEF1 LEF1 GADD45B GADD45B FZD7 FZD7 WNT11 WNT11 DVL2 DVL2 AXIN2 AXIN2 WNT5A WNT5A WNT1 WNT1 WNT16 WNT16 WNT9A WNT9A SUFU SUFU FZD8 FZD8 FZD3 FZD3 WNT6 WNT6 GLI1 GLI1 TCF7L2 TCF7L2 KIF7 KIF7 KIF27 KIF27 FZD4 FZD4 HHIP HHIP FZD6 FZD6 DVL3 DVL3 BAK1 BAK1 ENSPCOP00000018033 ENSPCOP00000018033 FZD2 FZD2 BAX BAX GADD45G GADD45G DDB2 DDB2 WNT4 WNT4 GADD45A GADD45A PTCH1 PTCH1 WNT9B WNT9B CTNNB1 CTNNB1 GSK3B GSK3B APC2 APC2 WNT3 WNT3 WNT3A WNT3A WNT8A WNT8A DVL1 DVL1 SMO SMO BMP4 BMP4 WNT8B WNT8B APC APC WNT10A WNT10A POLK POLK TCF7L1 TCF7L1 AXIN1 AXIN1 WNT2 WNT2 BMP2 BMP2 TCF7 TCF7 WNT5B WNT5B TP53 TP53 PTCH2 PTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLI2GLI family zinc finger 2. (1590 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
GLI3GLI family zinc finger 3. (1580 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
AXIN2Axin 2. (716 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (406 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GLI1GLI family zinc finger 1. (1106 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1341 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1309 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
HHIPHedgehog interacting protein. (701 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSPCOP00000018033HH_signal domain-containing protein. (110 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PTCH1Patched 1. (1449 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
CTNNB1Catenin beta 1. (781 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
APC2APC regulator of WNT signaling pathway 2. (2300 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
DVL1Dishevelled segment polarity protein 1. (722 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
POLKDNA polymerase kappa. (832 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
AXIN1Axin 1. (865 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TCF7Transcription factor 7. (303 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
PTCH2Patched 2. (1207 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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