STRINGSTRING
PPP1R14B PPP1R14B FGF2 FGF2 FGF4 FGF4 FGF20 FGF20 TP53 TP53 FGF18 FGF18 PDGFD PDGFD FGF8 FGF8 LOC105812777 LOC105812777 PDGFRB PDGFRB EGF EGF CSDE1 CSDE1 ARAF ARAF RB1 RB1 FGF1 FGF1 GALK2 GALK2 KRAS KRAS PDGFC PDGFC E2F3 E2F3 CDH1 CDH1 FGF22 FGF22 MAPK3 MAPK3 PIK3R3 PIK3R3 LOC105812775 LOC105812775 FGF9 FGF9 NRAS NRAS RAF1 RAF1 GADD45B GADD45B FGF23 FGF23 LOC105805030 LOC105805030 PDGFB PDGFB ENSPCOP00000002686 ENSPCOP00000002686 FGFR1 FGFR1 CDK4 CDK4 FGF16 FGF16 PTEN PTEN MAP2K2 MAP2K2 FGF10 FGF10 E2F2 E2F2 PIK3CA PIK3CA MAP2K1 MAP2K1 PIK3CB PIK3CB FGF19 FGF19 BAK1 BAK1 LOC105822621 LOC105822621 E2F1 E2F1 HGF HGF EGFR EGFR ENSPCOP00000015102 ENSPCOP00000015102 PIK3R2 PIK3R2 PIK3R1 PIK3R1 AKT2 AKT2 IGF1 IGF1 BAX BAX HRAS HRAS GADD45G GADD45G DDB2 DDB2 IGF1R IGF1R MET MET GADD45A GADD45A BRAF BRAF FGF17 FGF17 PDGFA PDGFA ENSPCOP00000024796 ENSPCOP00000024796 PDGFRA PDGFRA CDKN2A CDKN2A FGF7 FGF7 CDK6 CDK6 FGF3 FGF3 MITF MITF AKT3 AKT3 AKT1 AKT1 FGF21 FGF21 CCND1 CCND1 POLK POLK MAPK1 MAPK1 PIK3CD PIK3CD BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP1R14BUncharacterized protein. (147 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFDPlatelet derived growth factor D. (349 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
LOC105812777Uncharacterized protein. (436 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
EGFEpidermal growth factor. (1132 aa)
CSDE1Cold shock domain containing E1. (798 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
RB1RB transcriptional corepressor 1. (787 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GALK2Galactokinase 2. (458 aa)
KRASUncharacterized protein. (75 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (284 aa)
E2F3E2F transcription factor 3. (464 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (904 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
LOC105805030Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (150 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
E2F2E2F transcription factor 2. (435 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
LOC105822621Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
E2F1E2F transcription factor 1. (436 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
PIK3R2Uncharacterized protein. (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IGF1Insulin like growth factor 1. (208 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
POLKDNA polymerase kappa. (832 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BADBCL2 associated agonist of cell death. (168 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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