STRINGSTRING
TP53 TP53 RASSF1 RASSF1 MAPK1 MAPK1 CCND1 CCND1 ERBB2 ERBB2 FGFR3 FGFR3 CDKN2A CDKN2A THBS1 THBS1 CXCL8 CXCL8 BRAF BRAF VEGFA VEGFA DAPK3 DAPK3 MMP1 MMP1 TYMP TYMP HRAS HRAS SRC SRC EGFR EGFR E2F1 E2F1 MAP2K1 MAP2K1 EGF EGF LOC105812777 LOC105812777 CSDE1 CSDE1 MMP9 MMP9 ARAF ARAF UPK3A UPK3A RB1 RB1 KRAS KRAS DAPK1 DAPK1 E2F3 E2F3 CDH1 CDH1 MAPK3 MAPK3 MMP2 MMP2 DAPK2 DAPK2 LOC105812775 LOC105812775 E2F2 E2F2 MAP2K2 MAP2K2 CDK4 CDK4 ENSPCOP00000002686 ENSPCOP00000002686 MYC MYC RPS6KA5 RPS6KA5 RAF1 RAF1 NRAS NRAS HBEGF HBEGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RASSF1Ras association domain family member 1. (349 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (152 aa)
THBS1Thrombospondin 1. (1185 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
MMP1Matrix metallopeptidase 1. (414 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (488 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SRCTyrosine-protein kinase. (543 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
E2F1E2F transcription factor 1. (436 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
EGFEpidermal growth factor. (1132 aa)
LOC105812777Uncharacterized protein. (436 aa)
CSDE1Cold shock domain containing E1. (798 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
UPK3AUroplakin 3A. (242 aa)
RB1RB transcriptional corepressor 1. (787 aa)
KRASUncharacterized protein. (75 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
E2F3E2F transcription factor 3. (464 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (904 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
LOC105812775SWIB domain-containing protein. (243 aa)
E2F2E2F transcription factor 2. (435 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
RPS6KA5Ribosomal protein S6 kinase A5. (643 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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