STRINGSTRING
KRAS KRAS STAT5B STAT5B CCNA1 CCNA1 CSF1R CSF1R IKBKG IKBKG SPI1 SPI1 SPIB SPIB AKT3 AKT3 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EIF4EBP1 EIF4EBP1 GRB2 GRB2 PIK3CB PIK3CB MAP2K1 MAP2K1 MPO MPO PIK3CA PIK3CA ENSPCOP00000015102 ENSPCOP00000015102 CEBPE CEBPE RUNX1T1 RUNX1T1 RPS6KB2 RPS6KB2 CSDE1 CSDE1 TCF7L2 TCF7L2 JUP JUP ARAF ARAF CSF2 CSF2 AKT1 AKT1 SOS2 SOS2 LOC105821782 LOC105821782 SOS1 SOS1 PIM1 PIM1 MAPK3 MAPK3 NFKB1 NFKB1 PIK3R3 PIK3R3 CCNA2 CCNA2 NRAS NRAS RAF1 RAF1 LEF1 LEF1 MYC MYC ENSPCOP00000002686 ENSPCOP00000002686 BCL2A1 BCL2A1 ENSPCOP00000002148 ENSPCOP00000002148 MTOR MTOR MAP2K2 MAP2K2 ZBTB16 ZBTB16 DUSP6 DUSP6 CCND1 CCND1 CHUK CHUK TCF7L1 TCF7L1 MAPK1 MAPK1 STAT3 STAT3 PIK3CD PIK3CD BAD BAD PPP1R14B PPP1R14B PPARD PPARD PER2 PER2 RPS6KB1 RPS6KB1 TCF7 TCF7 RELA RELA AKT2 AKT2 HRAS HRAS PML PML IKBKB IKBKB CD14 CD14 STAT5A STAT5A KIT KIT RARA RARA FLT3 FLT3 BRAF BRAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASUncharacterized protein. (75 aa)
STAT5BSignal transducer and activator of transcription. (667 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (442 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
SPI1Spi-1 proto-oncogene. (272 aa)
SPIBETS domain-containing protein. (262 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
MPOMyeloperoxidase. (742 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (660 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
CSDE1Cold shock domain containing E1. (798 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
JUPJunction plakoglobin. (745 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
CSF2Colony stimulating factor 2. (146 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
LOC105821782Uncharacterized protein. (380 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (401 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
PIK3R3Uncharacterized protein. (454 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
BCL2A1BCL2 related protein A1. (173 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPP1R14BUncharacterized protein. (147 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
PER2Period circadian regulator 2. (1265 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
TCF7Transcription factor 7. (303 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PMLPromyelocytic leukemia. (887 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
STAT5ASignal transducer and activator of transcription. (805 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
RARARetinoic acid receptor alpha. (472 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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