STRINGSTRING
SECISBP2 SECISBP2 CCND1 CCND1 CHUK CHUK POLK POLK PIK3CD PIK3CD TRAF5 TRAF5 CDK2 CDK2 TP53 TP53 LOC105815609 LOC105815609 CASP9 CASP9 RELA RELA CDKN2B CDKN2B AKT1 AKT1 TRAF1 TRAF1 AKT3 AKT3 CDKN1B CDKN1B ENSPCOP00000027604 ENSPCOP00000027604 LOC105807375 LOC105807375 ENSPCOP00000027345 ENSPCOP00000027345 IKBKG IKBKG ENSPCOP00000027261 ENSPCOP00000027261 LAMC3 LAMC3 ITGA2B ITGA2B ENSPCOP00000027105 ENSPCOP00000027105 ITGA2 ITGA2 SKP2 SKP2 ENSPCOP00000026516 ENSPCOP00000026516 CDK6 CDK6 PTK2 PTK2 FN1 FN1 ENSPCOP00000024796 ENSPCOP00000024796 LAMB4 LAMB4 NOS2 NOS2 ITGA3 ITGA3 MAX MAX ENSPCOP00000023440 ENSPCOP00000023440 ENSPCOP00000023228 ENSPCOP00000023228 RARB RARB GADD45A GADD45A LAMB1 LAMB1 LAMA2 LAMA2 COL4A5 COL4A5 BIRC2 BIRC2 IKBKB IKBKB BCL2 BCL2 BCL2L1 BCL2L1 DDB2 DDB2 CKS1B CKS1B RXRG RXRG GADD45G GADD45G COL4A1 COL4A1 BAX BAX AKT2 AKT2 PIK3R1 PIK3R1 PIK3R2 PIK3R2 E2F1 E2F1 ITGA6 ITGA6 CASP3 CASP3 COL4A2 COL4A2 APAF1 APAF1 BAK1 BAK1 LAMC2 LAMC2 PIK3CB PIK3CB COL4A6 COL4A6 PIK3CA PIK3CA LAMA5 LAMA5 TRAF2 TRAF2 NFKBIA NFKBIA C7orf31 C7orf31 LAMA3 LAMA3 LAMA4 LAMA4 RB1 RB1 ITGAV ITGAV XIAP XIAP LAMB3 LAMB3 COL4A3 COL4A3 PTGS2 PTGS2 E2F3 E2F3 BIRC7 BIRC7 NFKB1 NFKB1 PIK3R3 PIK3R3 LAMC1 LAMC1 RXRB RXRB TRAF3 TRAF3 CCNE2 CCNE2 RXRA RXRA CKS2 CKS2 GADD45B GADD45B ENSPCOP00000004684 ENSPCOP00000004684 MYC MYC LOC105808398 LOC105808398 LAMA1 LAMA1 BIRC3 BIRC3 ITGB1 ITGB1 COL4A4 COL4A4 CDK4 CDK4 PTEN PTEN TRAF4 TRAF4 ZBTB17 ZBTB17 LAMB2 LAMB2 TRAF6 TRAF6 E2F2 E2F2 CCNE1 CCNE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SECISBP2SECIS binding protein 2. (856 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
POLKDNA polymerase kappa. (832 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (536 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
LOC105815609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRAF1TNF receptor-associated factor. (415 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSPCOP00000027604Uncharacterized protein. (196 aa)
LOC105807375Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSPCOP00000027345Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (64 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
ENSPCOP00000027261Uncharacterized protein. (113 aa)
LAMC3Laminin subunit gamma 3. (1574 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
ENSPCOP00000027105Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
ENSPCOP00000026516Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDK6Cyclin dependent kinase 6. (263 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
FN1Fibronectin 1. (2290 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
LAMB4Laminin subunit beta 4. (1656 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
MAXMYC associated factor X. (160 aa)
ENSPCOP00000023440Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
ENSPCOP00000023228Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
RARBRetinoic acid receptor beta. (448 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
LAMA2Laminin subunit alpha 2. (2944 aa)
COL4A5Collagen type IV alpha 5 chain. (1516 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
BCL2L1BCL2 like 1. (233 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
RXRGRetinoid X receptor gamma. (463 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (161 aa)
COL4A1Collagen type IV alpha 1 chain. (1670 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
E2F1E2F transcription factor 1. (436 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
APAF1Apoptotic peptidase activating factor 1. (1204 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
COL4A6Collagen type IV alpha 6 chain. (1706 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
LAMA3Laminin subunit alpha 3. (3336 aa)
LAMA4Laminin subunit alpha 4. (1816 aa)
RB1RB transcriptional corepressor 1. (787 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
COL4A3Collagen type IV alpha 3 chain. (1545 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
E2F3E2F transcription factor 3. (464 aa)
BIRC7Baculoviral IAP repeat containing 7. (283 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
PIK3R3Uncharacterized protein. (454 aa)
LAMC1Laminin subunit gamma 1. (1494 aa)
RXRBRetinoid X receptor beta. (535 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
RXRARetinoid X receptor alpha. (469 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
ENSPCOP00000004684Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
LOC105808398Bis(5'-adenosyl)-triphosphatase. (148 aa)
LAMA1Laminin subunit alpha 1. (2945 aa)
BIRC3Baculoviral IAP repeat containing 3. (597 aa)
ITGB1Integrin beta. (585 aa)
COL4A4Collagen type IV alpha 4 chain. (1691 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TRAF4TNF receptor-associated factor. (470 aa)
ZBTB17Zinc finger and BTB domain containing 17. (798 aa)
LAMB2Laminin subunit beta 2. (1793 aa)
TRAF6TNF receptor-associated factor. (498 aa)
E2F2E2F transcription factor 2. (435 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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