STRINGSTRING
AKT2 AKT2 SIRT6 SIRT6 TP53 TP53 ENSPCOP00000031755 ENSPCOP00000031755 G6PD G6PD PARP8 PARP8 GLS GLS PFKP PFKP PDGFRB PDGFRB FGFR2 FGFR2 PIK3CD PIK3CD ENSPCOP00000030058 ENSPCOP00000030058 MAPK1 MAPK1 AKT1 AKT1 AKT3 AKT3 ERBB2 ERBB2 FGFR3 FGFR3 NTRK3 NTRK3 SLC16A3 SLC16A3 ENSPCOP00000026464 ENSPCOP00000026464 SLC7A5 SLC7A5 PDGFRA PDGFRA HK3 HK3 SLC1A5 SLC1A5 ENSPCOP00000024796 ENSPCOP00000024796 SCO1 SCO1 FLT3 FLT3 HKDC1 HKDC1 PKM PKM KIT KIT RET RET LDHB LDHB PFKM PFKM MET MET ENSPCOP00000021134 ENSPCOP00000021134 ENSPCOP00000020173 ENSPCOP00000020173 GCK GCK HRAS HRAS TNIK TNIK IDH1 IDH1 PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR PDHA1 PDHA1 PIK3CB PIK3CB MAP2K1 MAP2K1 PIK3CA PIK3CA IDH2 IDH2 GLS2 GLS2 SIRT3 SIRT3 PDHB PDHB HK2 HK2 CSDE1 CSDE1 LOC105817330 LOC105817330 NTRK1 NTRK1 PARP6 PARP6 ENSPCOP00000009899 ENSPCOP00000009899 KRAS KRAS PGAM1 PGAM1 PGAM2 PGAM2 MAPK3 MAPK3 PIK3R3 PIK3R3 SLC2A2 SLC2A2 ENSPCOP00000006746 ENSPCOP00000006746 HK1 HK1 NRAS NRAS RAF1 RAF1 HIF1A HIF1A ENSPCOP00000004635 ENSPCOP00000004635 ENSPCOP00000003860 ENSPCOP00000003860 MYC MYC PDK1 PDK1 TIGAR TIGAR PFKL PFKL ENSPCOP00000002686 ENSPCOP00000002686 FGFR1 FGFR1 SLC2A1 SLC2A1 ENSPCOP00000001921 ENSPCOP00000001921 MTOR MTOR PTEN PTEN MAP2K2 MAP2K2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SIRT6Sirtuin 6. (305 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
ENSPCOP00000031755Uncharacterized protein; Belongs to the LDH/MDH superfamily. (324 aa)
G6PDGlucose-6-phosphate dehydrogenase. (558 aa)
PARP8Poly [ADP-ribose] polymerase. (784 aa)
GLSGlutaminase. (554 aa)
PFKPPhosphofructokinase, platelet. (751 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENSPCOP00000030058Uncharacterized protein. (55 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
NTRK3Tyrosine-protein kinase receptor. (865 aa)
SLC16A3Solute carrier family 16 member 3. (466 aa)
ENSPCOP00000026464Uncharacterized protein. (46 aa)
SLC7A5Solute carrier family 7 member 5. (489 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
HK3Hexokinase 3. (924 aa)
SLC1A5Amino acid transporter. (540 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (305 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
HKDC1Hexokinase domain containing 1. (869 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
LDHBLdh_1_N domain-containing protein. (252 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (858 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
ENSPCOP00000021134E1_dh domain-containing protein. (188 aa)
ENSPCOP00000020173Ldh_1_C domain-containing protein. (58 aa)
GCKPhosphotransferase. (466 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TNIKTRAF2 and NCK interacting kinase. (1363 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (381 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (387 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (450 aa)
GLS2Glutaminase 2. (598 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (361 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
HK2Hexokinase 2. (841 aa)
CSDE1Cold shock domain containing E1. (798 aa)
LOC105817330L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
ENSPCOP00000009899L-lactate dehydrogenase. (243 aa)
KRASUncharacterized protein. (75 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3R3Uncharacterized protein. (454 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
ENSPCOP00000006746Uncharacterized protein. (188 aa)
HK1Hexokinase 1. (881 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ENSPCOP00000004635L-lactate dehydrogenase. (233 aa)
ENSPCOP00000003860Ldh_1_C domain-containing protein. (87 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PFKLPhosphofructokinase, liver type. (687 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (495 aa)
ENSPCOP00000001921L-lactate dehydrogenase. (273 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.