STRINGSTRING
CTNNB1 CTNNB1 RELA RELA FOS FOS ENSPCOP00000000307 ENSPCOP00000000307 PRKCZ PRKCZ PIAS4 PIAS4 RAC3 RAC3 IL1R1 IL1R1 MAPK9 MAPK9 LOC105822640 LOC105822640 SUMO1 SUMO1 ENSPCOP00000002207 ENSPCOP00000002207 NFE2L2 NFE2L2 PECAM1 PECAM1 MAP2K7 MAP2K7 PDGFB PDGFB HMOX1 HMOX1 CAV3 CAV3 ACTB ACTB GPC1 GPC1 ENSPCOP00000005039 ENSPCOP00000005039 KDR KDR LOC105826847 LOC105826847 MAP3K7 MAP3K7 GSTO2 GSTO2 RHOA RHOA ACVR2B ACVR2B EDN1 EDN1 HSP90AB1 HSP90AB1 IL1R2 IL1R2 TXNDC8 TXNDC8 PLAT PLAT SELE SELE NCF1 NCF1 ENSPCOP00000007681 ENSPCOP00000007681 MMP2 MMP2 NCF2 NCF2 PIK3R3 PIK3R3 NFKB1 NFKB1 TXN TXN CCL2 CCL2 MEF2C MEF2C LOC105819868 LOC105819868 RAC2 RAC2 CALM1 CALM1 ENSPCOP00000009730 ENSPCOP00000009730 NOS3 NOS3 GSTM3 GSTM3 ENSPCOP00000009948 ENSPCOP00000009948 ASS1 ASS1 ACTL8 ACTL8 ARHGEF2 ARHGEF2 ACVR2A ACVR2A ITGAV ITGAV ENSPCOP00000010764 ENSPCOP00000010764 RHOC RHOC IL1B IL1B CALM3 CALM3 BMPR1A BMPR1A LOC105813810 LOC105813810 MMP9 MMP9 IL1A IL1A LOC105813798 LOC105813798 CALM2 CALM2 ENSPCOP00000013947 ENSPCOP00000013947 MAPK12 MAPK12 SUMO3 SUMO3 MAPK11 MAPK11 BMPR1B BMPR1B BMPR2 BMPR2 SQSTM1 SQSTM1 TNF TNF PVALEF PVALEF PIK3CA PIK3CA MAPK7 MAPK7 MAP3K5 MAP3K5 MGST1 MGST1 PIK3CB PIK3CB ACVR1 ACVR1 MAP2K5 MAP2K5 RAC1 RAC1 VCAM1 VCAM1 MAPK14 MAPK14 CTSL CTSL CALML4 CALML4 NPPC NPPC GSTA5 GSTA5 GSTT4 GSTT4 ICAM1 ICAM1 LOC105812452 LOC105812452 PIK3R2 PIK3R2 ENSPCOP00000018448 ENSPCOP00000018448 PIK3R1 PIK3R1 ENSPCOP00000018566 ENSPCOP00000018566 SRC SRC NQO1 NQO1 AKT2 AKT2 CDH5 CDH5 TXN2 TXN2 MGST3 MGST3 SUMO2 SUMO2 ENSPCOP00000020344 ENSPCOP00000020344 IFNG IFNG BCL2 BCL2 MEF2A MEF2A IKBKB IKBKB MAPK10 MAPK10 ACTG1 ACTG1 SDC4 SDC4 PRKAA1 PRKAA1 ENSPCOP00000023835 ENSPCOP00000023835 SDC1 SDC1 VEGFA VEGFA CYBA CYBA ENSPCOP00000024532 ENSPCOP00000024532 PDGFA PDGFA CAV1 CAV1 KLF2 KLF2 GSTA4 GSTA4 GSTP1 GSTP1 MAP2K6 MAP2K6 ENSPCOP00000025645 ENSPCOP00000025645 PTK2 PTK2 HSP90B1 HSP90B1 SDC2 SDC2 CAV2 CAV2 DUSP1 DUSP1 ITGA2B ITGA2B KEAP1 KEAP1 IKBKG IKBKG PRKAA2 PRKAA2 TNFRSF1A TNFRSF1A MAPK8 MAPK8 BMP4 BMP4 MGST2 MGST2 AKT3 AKT3 ENSPCOP00000028553 ENSPCOP00000028553 AKT1 AKT1 LOC105813799 LOC105813799 CHUK CHUK LOC105824194 LOC105824194 NOX1 NOX1 PIK3CD PIK3CD MAPK13 MAPK13 TRPV4 TRPV4 HSP90AA1 HSP90AA1 LOC105821004 LOC105821004 MAP2K4 MAP2K4 ENSPCOP00000031725 ENSPCOP00000031725 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (781 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
ENSPCOP00000000307Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PIAS4Protein inhibitor of activated STAT 4. (465 aa)
RAC3Rac family small GTPase 3. (205 aa)
IL1R1Interleukin 1 receptor type 1. (516 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
ENSPCOP00000002207Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (698 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ACTBActin beta. (378 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
ENSPCOP00000005039GST N-terminal domain-containing protein. (49 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
LOC105826847Uncharacterized protein; Belongs to the GST superfamily. (201 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
RHOARas homolog family member A. (193 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (529 aa)
EDN1Endothelin 1. (193 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (715 aa)
IL1R2Interleukin 1 receptor type 2. (424 aa)
TXNDC8Thioredoxin domain-containing protein. (100 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
SELESelectin E. (610 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
ENSPCOP00000007681EF-hand domain-containing protein. (132 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PIK3R3Uncharacterized protein. (454 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
TXNThioredoxin domain-containing protein. (91 aa)
CCL2C-C motif chemokine. (99 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
RAC2Rac family small GTPase 2. (192 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ENSPCOP00000009730Uncharacterized protein. (164 aa)
NOS3Nitric oxide synthase 3. (994 aa)
GSTM3Glutathione S-transferase. (225 aa)
ENSPCOP00000009948Uncharacterized protein. (605 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
ACTL8Actin like 8; Belongs to the actin family. (351 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1013 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (416 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ENSPCOP00000010764EF-hand domain-containing protein; Belongs to the calmodulin family. (109 aa)
RHOCRas homolog family member C. (193 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
LOC105813810Uncharacterized protein. (222 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
LOC105813798Uncharacterized protein; Belongs to the GST superfamily. (223 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (138 aa)
ENSPCOP00000013947Small ubiquitin-related modifier. (91 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SUMO3Small ubiquitin-related modifier. (120 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
SQSTM1Sequestosome 1. (440 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
PVALEFParvalbumin like EF-hand containing. (126 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
MAP2K5Mitogen-activated protein kinase kinase 5. (389 aa)
RAC1Rac family small GTPase 1. (211 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
CALML4Calmodulin like 4. (178 aa)
NPPCNatriuretic peptide C. (126 aa)
GSTA5Glutathione S-transferase alpha 5; Belongs to the GST superfamily. (222 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
LOC105812452HATPase_c domain-containing protein. (680 aa)
PIK3R2Uncharacterized protein. (726 aa)
ENSPCOP00000018448Uncharacterized protein. (87 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSPCOP00000018566Uncharacterized protein. (113 aa)
SRCTyrosine-protein kinase. (543 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (270 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
TXN2Thioredoxin 2. (166 aa)
MGST3Uncharacterized protein. (170 aa)
SUMO2Rad60-SLD domain-containing protein. (136 aa)
ENSPCOP00000020344Rad60-SLD domain-containing protein. (73 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
MEF2AMyocyte enhancer factor 2A. (495 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
ACTG1Actin gamma 1. (404 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (200 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSPCOP00000023835Uncharacterized protein. (59 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
ENSPCOP00000024532Uncharacterized protein; Belongs to the calmodulin family. (142 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
KLF2Kruppel like factor 2. (356 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
ENSPCOP00000025645Uncharacterized protein. (162 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
HSP90B1HATPase_c domain-containing protein. (793 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSPCOP00000028553HATPase_c domain-containing protein. (333 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC105813799Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
LOC105824194Ubiquitin-like domain-containing protein. (101 aa)
NOX1NADPH oxidase 1. (564 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (816 aa)
LOC105821004Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (18%) [HD]