STRINGSTRING
SLX1 SLX1 G3XMF0_ASPNA G3XMF0_ASPNA G3XMU0_ASPNA G3XMU0_ASPNA G3XMY2_ASPNA G3XMY2_ASPNA G3XN54_ASPNA G3XN54_ASPNA G3XN56_ASPNA G3XN56_ASPNA G3XN97_ASPNA G3XN97_ASPNA G3XNF5_ASPNA G3XNF5_ASPNA G3XNZ7_ASPNA G3XNZ7_ASPNA ASN41996 ASN41996 G3XPJ6_ASPNA G3XPJ6_ASPNA G3XPL3_ASPNA G3XPL3_ASPNA G3XPT6_ASPNA G3XPT6_ASPNA G3XPT9_ASPNA G3XPT9_ASPNA G3XPV4_ASPNA G3XPV4_ASPNA G3XPW1_ASPNA G3XPW1_ASPNA G3XQW7_ASPNA G3XQW7_ASPNA G3XRC1_ASPNA G3XRC1_ASPNA G3XRR9_ASPNA G3XRR9_ASPNA G3XRV4_ASPNA G3XRV4_ASPNA G3XS52_ASPNA G3XS52_ASPNA G3XS56_ASPNA G3XS56_ASPNA G3XSC3_ASPNA G3XSC3_ASPNA G3XT02_ASPNA G3XT02_ASPNA G3XT30_ASPNA G3XT30_ASPNA G3XT57_ASPNA G3XT57_ASPNA G3XUM6_ASPNA G3XUM6_ASPNA G3XVJ1_ASPNA G3XVJ1_ASPNA G3XVJ4_ASPNA G3XVJ4_ASPNA G3XWW2_ASPNA G3XWW2_ASPNA G3XWW5_ASPNA G3XWW5_ASPNA G3XX42_ASPNA G3XX42_ASPNA G3XXD6_ASPNA G3XXD6_ASPNA G3XXP7_ASPNA G3XXP7_ASPNA G3XXQ3_ASPNA G3XXQ3_ASPNA G3XY97_ASPNA G3XY97_ASPNA G3XZ45_ASPNA G3XZ45_ASPNA G3XZQ1_ASPNA G3XZQ1_ASPNA G3XZR3_ASPNA G3XZR3_ASPNA G3XZV1_ASPNA G3XZV1_ASPNA G3Y085_ASPNA G3Y085_ASPNA G3Y0C8_ASPNA G3Y0C8_ASPNA G3Y0E7_ASPNA G3Y0E7_ASPNA G3Y0R2_ASPNA G3Y0R2_ASPNA G3Y0U9_ASPNA G3Y0U9_ASPNA G3Y142_ASPNA G3Y142_ASPNA G3Y1A5_ASPNA G3Y1A5_ASPNA G3Y1S0_ASPNA G3Y1S0_ASPNA G3Y1W5_ASPNA G3Y1W5_ASPNA G3Y1Y6_ASPNA G3Y1Y6_ASPNA G3Y201_ASPNA G3Y201_ASPNA G3Y203_ASPNA G3Y203_ASPNA G3Y286_ASPNA G3Y286_ASPNA G3Y294_ASPNA G3Y294_ASPNA G3Y2T2_ASPNA G3Y2T2_ASPNA G3Y2T4_ASPNA G3Y2T4_ASPNA G3Y2W7_ASPNA G3Y2W7_ASPNA G3Y370_ASPNA G3Y370_ASPNA G3Y383_ASPNA G3Y383_ASPNA G3Y3G1_ASPNA G3Y3G1_ASPNA G3Y3H7_ASPNA G3Y3H7_ASPNA G3Y581_ASPNA G3Y581_ASPNA G3Y5C5_ASPNA G3Y5C5_ASPNA G3Y5M5_ASPNA G3Y5M5_ASPNA G3Y5M9_ASPNA G3Y5M9_ASPNA G3Y5R4_ASPNA G3Y5R4_ASPNA G3Y5U7_ASPNA G3Y5U7_ASPNA G3Y5Z6_ASPNA G3Y5Z6_ASPNA G3Y618_ASPNA G3Y618_ASPNA MCM7 MCM7 G3Y690_ASPNA G3Y690_ASPNA G3Y6S1_ASPNA G3Y6S1_ASPNA G3Y6X1_ASPNA G3Y6X1_ASPNA G3Y723_ASPNA G3Y723_ASPNA G3Y7B8_ASPNA G3Y7B8_ASPNA G3Y7Y0_ASPNA G3Y7Y0_ASPNA G3Y8P6_ASPNA G3Y8P6_ASPNA G3Y8W0_ASPNA G3Y8W0_ASPNA G3Y910_ASPNA G3Y910_ASPNA G3Y991_ASPNA G3Y991_ASPNA G3Y992_ASPNA G3Y992_ASPNA G3Y9D4_ASPNA G3Y9D4_ASPNA G3Y9H7_ASPNA G3Y9H7_ASPNA G3YA04_ASPNA G3YA04_ASPNA G3YA34_ASPNA G3YA34_ASPNA G3YA53_ASPNA G3YA53_ASPNA G3YA68_ASPNA G3YA68_ASPNA G3YAC9_ASPNA G3YAC9_ASPNA G3YAL0_ASPNA G3YAL0_ASPNA G3YAT2_ASPNA G3YAT2_ASPNA G3YBG6_ASPNA G3YBG6_ASPNA G3YBN8_ASPNA G3YBN8_ASPNA G3YBS8_ASPNA G3YBS8_ASPNA FEN1 FEN1 G3YBU4_ASPNA G3YBU4_ASPNA G3YBZ0_ASPNA G3YBZ0_ASPNA G3YC28_ASPNA G3YC28_ASPNA G3YC60_ASPNA G3YC60_ASPNA G3YCV4_ASPNA G3YCV4_ASPNA G3YDU7_ASPNA G3YDU7_ASPNA G3YDZ0_ASPNA G3YDZ0_ASPNA G3YES0_ASPNA G3YES0_ASPNA G3YGA7_ASPNA G3YGA7_ASPNA G3YGB4_ASPNA G3YGB4_ASPNA G3YGG9_ASPNA G3YGG9_ASPNA G3YGR5_ASPNA G3YGR5_ASPNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
protein homology
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SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (424 aa)
G3XMF0_ASPNADNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1165 aa)
G3XMU0_ASPNABTP domain-containing protein. (905 aa)
G3XMY2_ASPNADNA helicase; Belongs to the MCM family. (851 aa)
G3XN54_ASPNAUncharacterized protein; Belongs to the PI3/PI4-kinase family. (2461 aa)
G3XN56_ASPNAChromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (271 aa)
G3XN97_ASPNAUncharacterized protein. (1108 aa)
G3XNF5_ASPNAUncharacterized protein. (764 aa)
G3XNZ7_ASPNADNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (650 aa)
ASN41996Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2796 aa)
G3XPJ6_ASPNAUncharacterized protein. (557 aa)
G3XPL3_ASPNADNA helicase; Belongs to the MCM family. (922 aa)
G3XPT6_ASPNA3'-5' exonuclease domain-containing protein. (309 aa)
G3XPT9_ASPNACell division control protein; Belongs to the CDC6/cdc18 family. (607 aa)
G3XPV4_ASPNADNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1107 aa)
G3XPW1_ASPNAProtein kinase domain-containing protein. (245 aa)
G3XQW7_ASPNAUncharacterized protein. (399 aa)
G3XRC1_ASPNAMCM domain-containing protein; Belongs to the MCM family. (2047 aa)
G3XRR9_ASPNAUncharacterized protein. (860 aa)
G3XRV4_ASPNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (922 aa)
G3XS52_ASPNADNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (500 aa)
G3XS56_ASPNAUncharacterized protein. (555 aa)
G3XSC3_ASPNAUncharacterized protein. (858 aa)
G3XT02_ASPNAUncharacterized protein. (541 aa)
G3XT30_ASPNASld5 domain-containing protein. (223 aa)
G3XT57_ASPNADNA repair protein RAD1. (466 aa)
G3XUM6_ASPNAUmuC domain-containing protein. (604 aa)
G3XVJ1_ASPNADNA ligase. (915 aa)
G3XVJ4_ASPNADNA helicase; Belongs to the MCM family. (1028 aa)
G3XWW2_ASPNAHORMA domain-containing protein. (277 aa)
G3XWW5_ASPNAUncharacterized protein. (396 aa)
G3XX42_ASPNADNA polymerase. (1105 aa)
G3XXD6_ASPNAAAA domain-containing protein. (342 aa)
G3XXP7_ASPNACheckpoint protein; Belongs to the HUS1 family. (382 aa)
G3XXQ3_ASPNAUncharacterized protein. (117 aa)
G3XY97_ASPNADNA mismatch repair protein. (850 aa)
G3XZ45_ASPNADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
G3XZQ1_ASPNAWD_REPEATS_REGION domain-containing protein. (838 aa)
G3XZR3_ASPNAEthD domain-containing protein. (153 aa)
G3XZV1_ASPNASAE2 domain-containing protein. (823 aa)
G3Y085_ASPNARECA_2 domain-containing protein. (490 aa)
G3Y0C8_ASPNAAAA domain-containing protein. (926 aa)
G3Y0E7_ASPNAFanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (825 aa)
G3Y0R2_ASPNAERCC4 domain-containing protein. (583 aa)
G3Y0U9_ASPNA5'-3' exonuclease. (543 aa)
G3Y142_ASPNAUncharacterized protein; Belongs to the cytochrome P450 family. (467 aa)
G3Y1A5_ASPNADNA helicase; Belongs to the MCM family. (720 aa)
G3Y1S0_ASPNAProtein kinase domain-containing protein. (784 aa)
G3Y1W5_ASPNAAAA domain-containing protein. (758 aa)
G3Y1Y6_ASPNADNA mismatch repair protein. (1043 aa)
G3Y201_ASPNAUncharacterized protein. (302 aa)
G3Y203_ASPNADNA polymerase. (1971 aa)
G3Y286_ASPNADNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (269 aa)
G3Y294_ASPNAAAA domain-containing protein. (734 aa)
G3Y2T2_ASPNAReplication factor C subunit 1. (1035 aa)
G3Y2T4_ASPNAAAA domain-containing protein. (352 aa)
G3Y2W7_ASPNAAA_TRNA_LIGASE_II domain-containing protein. (574 aa)
G3Y370_ASPNADNA_pol_E_B domain-containing protein. (748 aa)
G3Y383_ASPNAReplication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (592 aa)
G3Y3G1_ASPNAUncharacterized protein. (273 aa)
G3Y3H7_ASPNADNA ligase. (834 aa)
G3Y581_ASPNAAAA domain-containing protein. (396 aa)
G3Y5C5_ASPNADUF1767 domain-containing protein. (237 aa)
G3Y5M5_ASPNADNA primase; Belongs to the eukaryotic-type primase small subunit family. (514 aa)
G3Y5M9_ASPNA5'-3' exonuclease. (672 aa)
G3Y5R4_ASPNADNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2224 aa)
G3Y5U7_ASPNADNA_MISMATCH_REPAIR_2 domain-containing protein. (1653 aa)
G3Y5Z6_ASPNAZf-primase domain-containing protein. (775 aa)
G3Y618_ASPNANTF2 domain-containing protein. (122 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (807 aa)
G3Y690_ASPNAUncharacterized protein. (312 aa)
G3Y6S1_ASPNADNA_MISMATCH_REPAIR_2 domain-containing protein. (956 aa)
G3Y6X1_ASPNAORC_WH_C domain-containing protein. (677 aa)
G3Y723_ASPNAUncharacterized protein. (429 aa)
G3Y7B8_ASPNAUncharacterized protein. (571 aa)
G3Y7Y0_ASPNAUncharacterized protein. (662 aa)
G3Y8P6_ASPNAUncharacterized protein. (609 aa)
G3Y8W0_ASPNADNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1188 aa)
G3Y910_ASPNARif1_N domain-containing protein. (1594 aa)
G3Y991_ASPNASld5 domain-containing protein. (178 aa)
G3Y992_ASPNACnn_1N domain-containing protein. (896 aa)
G3Y9D4_ASPNAUmuC domain-containing protein. (606 aa)
G3Y9H7_ASPNAUncharacterized protein. (361 aa)
G3YA04_ASPNADNA mismatch repair protein. (943 aa)
G3YA34_ASPNAUncharacterized protein. (576 aa)
G3YA53_ASPNAUncharacterized protein. (166 aa)
G3YA68_ASPNAATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (541 aa)
G3YAC9_ASPNAUncharacterized protein. (444 aa)
G3YAL0_ASPNAPectinesterase; Involved in maceration and soft-rotting of plant tissue. (327 aa)
G3YAT2_ASPNADBF4-type domain-containing protein. (674 aa)
G3YBG6_ASPNADNA polymerase. (1668 aa)
G3YBN8_ASPNAUncharacterized protein. (197 aa)
G3YBS8_ASPNAAspartic protease; Belongs to the peptidase A1 family. (620 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (359 aa)
G3YBU4_ASPNAUncharacterized protein. (459 aa)
G3YBZ0_ASPNAUncharacterized protein. (417 aa)
G3YC28_ASPNAProtein kinase domain-containing protein. (491 aa)
G3YC60_ASPNADNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (266 aa)
G3YCV4_ASPNARecQ family helicase MusN. (1452 aa)
G3YDU7_ASPNADNA_mis_repair domain-containing protein. (721 aa)
G3YDZ0_ASPNAUncharacterized protein. (375 aa)
G3YES0_ASPNADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (792 aa)
G3YGA7_ASPNACBFD_NFYB_HMF domain-containing protein. (254 aa)
G3YGB4_ASPNASLD3 domain-containing protein. (908 aa)
G3YGG9_ASPNAOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (807 aa)
G3YGR5_ASPNADNA_MISMATCH_REPAIR_2 domain-containing protein. (485 aa)
Your Current Organism:
Aspergillus niger
NCBI taxonomy Id: 380704
Other names: A. niger ATCC 1015, Aspergillus niger ATCC 1015
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