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pdhA1 pdhA1 pdhB pdhB pdhL pdhL pdhA2 pdhA2 odhL odhL odhB odhB odhA odhA acoR acoR acoX acoX acoA acoA acoB acoB acoC acoC h16_B0147 h16_B0147 h16_B0148 h16_B0148 h16_B1098 h16_B1098 aceE aceE h16_B1765 h16_B1765 bkdA1 bkdA1 bkdA2 bkdA2 bkdB bkdB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdhA1Pyruvate dehydrogenase complex, dehydrogenase (E1) component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
pdhBDihydrolipoamide acetyltransferase (E2) component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (553 aa)
pdhLDihydrolipoamide dehydrogenase (E3) component ofpyruvate dehydrogenase. (594 aa)
pdhA2Pyruvate dehydrogenase complex, dehydrogenase (E1) component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa)
odhLDihydrolipoamide dehydrogenase (E3); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (474 aa)
odhBDihydrolipoamide S-succinyltransferase (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (416 aa)
odhA2-Oxoglutarate dehydrogenase (E1); E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (950 aa)
acoRTranscriptional regulator of acetoin catabolism,PspF-family; Required for sigma-54-dependent transcription of acoXABC. (668 aa)
acoXAcetoin catabolism protein X, putative ATP-NAD kinase; Essential for acetoin catabolism. (359 aa)
acoAAcetoin dehydrogenase E1 component alpha-subunit; Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The alpha subunit is probably the catalytic subunit of the enzyme. (333 aa)
acoBAcetoin dehydrogenase E1 component beta-subunit; Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The beta subunit is probably not the catalytic subunit of the enzyme. (338 aa)
acoCDihydrolipoamide S-acetyltransferase component of acetoin dehydrogenase complex; Dihydrolipoamide acetyltransferase involved in acetoin catabolism. (374 aa)
h16_B0147DNA-binding protein; To H.influenzae HI_1053 and P.denitrificans COX locus Uncharacterized protein 4. (113 aa)
h16_B0148Lipoate-protein ligase A. (253 aa)
h16_B1098Pyridinenucleotide-disulphide (lipoamid) oxidoreductase. (463 aa)
aceEPyruvate dehydrogenase complex, dehydrogenase (E1) component (lipoamide); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa)
h16_B1765Dihydrolipoamide dehydrogenase (E3); Deleted EC_number 1.8.1.1. (459 aa)
bkdA12-Oxoisovalerate dehydrogenase E1 component,alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
bkdA22-Oxoisovalerate dehydrogenase E1 component,beta subunit. (325 aa)
bkdBDihydrolipoyllysine-residue (2-methylpropanoyl)transferase. (372 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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