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hldC hldC h16_A0228 h16_A0228 h16_A0229 h16_A0229 gutQ gutQ h16_A0520 h16_A0520 rfaF3 rfaF3 kdsB kdsB lpxK lpxK hldA hldA hldD hldD rfaF2 rfaF2 kdsA kdsA h16_A2040 h16_A2040 rnhB rnhB lpxB lpxB lpxA lpxA h16_A2044 h16_A2044 lpxD lpxD rfaL rfaL kdtA kdtA rfaF1 rfaF1 lpxC lpxC gmhA2 gmhA2 h16_B0917 h16_B0917
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hldCD-beta-D-heptose 1-phosphate adenylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (164 aa)
h16_A0228Lauroyl/myristoyl acyltransferase. (297 aa)
h16_A0229Lauroyl/myristoyl acyltransferase. (298 aa)
gutQPredicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. (333 aa)
h16_A0520Histidinol phosphatase or related phosphatase. (195 aa)
rfaF3ADP-heptose:LPS heptosyltransferase III. (340 aa)
kdsB3-Deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (269 aa)
lpxKTetraacyldisaccharide-1-P 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (367 aa)
hldAD-beta-D-heptose 7-phophosphate kinase; Corresponds todomain I of RfaE from E. coli, involved in LPS biosynthesis. (315 aa)
hldDADP-D-beta-D-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (331 aa)
rfaF2ADP-heptose:LPS heptosyltransferase II. (328 aa)
kdsA2-Dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (289 aa)
h16_A204023S rRNA methyltransferase. (260 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (238 aa)
lpxBLipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (402 aa)
lpxAAcyl-ACP-UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (267 aa)
h16_A20443-Hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (363 aa)
rfaLMembrane spanning protein involved in lipopolysaccharide biosynthesis; 12 TMHs. (429 aa)
kdtA3-Deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (429 aa)
rfaF1ADP-heptose:LPS heptosyltransferase I. (368 aa)
lpxCUDP-3-O-Acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
gmhA2Sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (195 aa)
h16_B0917Lipid A biosynthesis lauroyl acyltransferase. (292 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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