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h16_A2747 h16_A2747 argC1 argC1 h16_A0232 h16_A0232 betA2 betA2 mmsA1 mmsA1 fdsA fdsA h16_A0745 h16_A0745 adh adh h16_A1114 h16_A1114 h16_A1495 h16_A1495 h16_A1772 h16_A1772 h16_A1806 h16_A1806 h16_A1919 h16_A1919 asd asd fdhC fdhC proA proA gapA gapA hemA hemA h16_A3345 h16_A3345 h16_A3587 h16_A3587 putA putA betA4 betA4 mmsA2 mmsA2 h16_B0130 h16_B0130 h16_B0212 h16_B0212 h16_B0322 h16_B0322 argC2 argC2 h16_B0421 h16_B0421 h16_B0547 h16_B0547 mhpF mhpF h16_B0596 h16_B0596 h16_B0737 h16_B0737 h16_B0833 h16_B0833 gabD1 gabD1 gabD2 gabD2 mmsA3 mmsA3 paaK2 paaK2 cbbG2 cbbG2 h16_B1406 h16_B1406 h16_B1425 h16_B1425 fdoI fdoI h16_B1532 h16_B1532 h16_B1534 h16_B1534 gabD3 gabD3 fdwA fdwA h16_B1735 h16_B1735 h16_B1751 h16_B1751 h16_B1835 h16_B1835 h16_B1851 h16_B1851 h16_B1879 h16_B1879 h16_B1917 h16_B1917 feaB feaB h16_B1947 h16_B1947 exaC exaC h16_B1984 h16_B1984 gabD4 gabD4 betB betB betA1 betA1 h16_B2444 h16_B2444
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
h16_A2747Acetaldehyde dehydrogenase (acetylating) NAD-dependent; Catalyzes the conversion of sulfoacetyl-CoA and NADPH to sulfoacetaldehyde, CoA and NADP(+). Specific for NADP(+) and sulfoacetaldehyde. (493 aa)
argC1N-Acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (315 aa)
h16_A0232NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (467 aa)
betA2Choline dehydrogenase. (559 aa)
mmsA1Methylmalonate-semialdehyde dehydrogenase. (505 aa)
fdsANAD-dependent formate dehydrogenase alpha subunit. (959 aa)
h16_A0745NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
adhAlcohol dehydrogenase; Multifunctional alcohol dehydrogenase exhibiting NAD(+)- dependent dehydrogenase activities for 2,3-butanediol, ethanol and acetaldehyde, and reductase activities for acetoin (NADH-dependent), and diacetyl and acetaldehyde (independently of whether NADH or NADPH is the reductant). The rate of oxidation of 2,3-butanediol is much higher than for the oxidation of ethanol. Has acetaldehyde dehydrogenase activity leading to acetate formation. May function in the release of excess reducing power in the absence of exogenous hydrogen acceptors such as oxygen. (366 aa)
h16_A1114NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
h16_A1495NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (493 aa)
h16_A1772Benzaldehyde dehydrogenase [NAD+]. (348 aa)
h16_A1806Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (216 aa)
h16_A1919Putative Lactaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (378 aa)
fdhCCytochrome b subunit of formate dehydrogenase; 5 TMHs. (402 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa)
gapAGlyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (434 aa)
h16_A3345Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family. (505 aa)
h16_A3587Hypothetical protein. (94 aa)
putABifunctional proline dehydrogenase and proline oxidase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1321 aa)
betA4Choline dehydrogenase; BetA. (555 aa)
mmsA2Methylmalonate-semialdehyde dehydrogenase. (508 aa)
h16_B01302,5-dioxovalerate dehydrogenase/2-oxoglutarate semialdehyde dehydrogenase. (508 aa)
h16_B0212NAD-dependent aldehyde dehydrogenase. (527 aa)
h16_B0322Aldehyde dehydrogenase, NAD-dependent. (534 aa)
argC2N-Acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (317 aa)
h16_B0421Aldehyde dehydrogenase, NAD(P)-dependent. (473 aa)
h16_B05472-Hydroxymuconic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (492 aa)
mhpFAcetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (314 aa)
h16_B0596Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (302 aa)
h16_B0737Aldehyde dehydrogenase, NAD-dependent; Belongs to the aldehyde dehydrogenase family. (492 aa)
h16_B0833NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (481 aa)
gabD1Succinate-semialdehyde dehydrogenase (NADP+); MEDLINE: 20033526; Belongs to the aldehyde dehydrogenase family. (483 aa)
gabD2Succinate-semialdehyde dehydrogenase (NADP+); Belongs to the aldehyde dehydrogenase family. (348 aa)
mmsA3Methylmalonate-semialdehyde dehydrogenase. (507 aa)
paaK2Phenylacetic acid degradation protein K,phenylacetaldehyde dehydrogenase. (554 aa)
cbbG2Glyceraldehyde 3-phosphate dehydrogenase; Could be involved in carbon fixation as a component of the Calvin cycle. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate [...] (336 aa)
h16_B1406Predicted nucleoside-diphosphate-sugar epimerase. (250 aa)
h16_B1425Transcriptional regulator, LysR-family; Belongs to the LysR transcriptional regulatory family. (604 aa)
fdoIFormate dehydrogenase gamma subunit; 4 TMHs. (221 aa)
h16_B1532Oxidoreductase. (566 aa)
h16_B1534Aldehyde dehydrogenase (NAD+). (473 aa)
gabD3Succinate-semialdehyde dehydrogenase (NADP+); Belongs to the aldehyde dehydrogenase family. (482 aa)
fdwATungsten-containing formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (938 aa)
h16_B1735NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
h16_B1751NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (499 aa)
h16_B1835Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. (477 aa)
h16_B1851Glucose-methanol-choline oxidoreductase. (551 aa)
h16_B1879Aldehyde dehydrogenase, NAD(P)-dependent; Belongs to the aldehyde dehydrogenase family. (481 aa)
h16_B1917Aldehyde dehydrogenase. (515 aa)
feaBPutative phenylacetaldehyde dehydrogenase. (486 aa)
h16_B1947Glyceraldehyde-3 dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)
exaCAldehyde dehydrogenase; Involved in the catabolism of acetoin and ethanol; Belongs to the aldehyde dehydrogenase family. (506 aa)
h16_B1984Conserved hypothetical protein; Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism. (252 aa)
gabD4Succinate-semialdehyde dehydrogenase (NADP+). (475 aa)
betBBetaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
betA1Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (578 aa)
h16_B2444NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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