STRINGSTRING
h16_A0991 h16_A0991 h16_A0072 h16_A0072 h16_A0130 h16_A0130 h16_A0142 h16_A0142 can can h16_A0186 h16_A0186 thiC thiC folB folB h16_A0377 h16_A0377 h16_A0427 h16_A0427 h16_A0431 h16_A0431 gloA1 gloA1 moaC moaC fba fba purK purK ebsC ebsC hpaI1 hpaI1 h16_A0674 h16_A0674 hutU2 hutU2 h16_A0703 h16_A0703 pheA pheA h16_A0869 h16_A0869 h16_A0870 h16_A0870 h16_A0873 h16_A0873 mgsA mgsA h16_A1005 h16_A1005 psd psd h16_A1101 h16_A1101 hemH hemH nth nth edd1 edd1 eno eno dapA1 dapA1 mvaB mvaB leuC1 leuC1 leuD1 leuD1 pyc pyc h16_A1258 h16_A1258 h16_A1259 h16_A1259 h16_A1278 h16_A1278 h16_A1296 h16_A1296 metY1 metY1 aroC aroC h16_A1380 h16_A1380 h16_A1410 h16_A1410 h16_A1422 h16_A1422 h16_A1457 h16_A1457 h16_A1479 h16_A1479 h16_A1526 h16_A1526 h16_A1547 h16_A1547 leuC2 leuC2 leuD2 leuD2 h16_A1560 h16_A1560 h16_A1568 h16_A1568 h16_A1679 h16_A1679 h16_A1716 h16_A1716 mhpE2 mhpE2 rfbB2 rfbB2 h16_A1885 h16_A1885 prpB prpB acnM acnM prpD1 prpD1 ptpS ptpS h16_A1925 h16_A1925 rspA rspA h16_A2044 h16_A2044 h16_A2123 h16_A2123 menC menC h16_A2141 h16_A2141 h16_A2147 h16_A2147 h16_A2151 h16_A2151 iclA iclA iclB iclB menG1 menG1 h16_A2250 h16_A2250 h16_A2258 h16_A2258 thrC thrC hmgL1 hmgL1 pcaB2 pcaB2 abmC abmC fumA fumA moaA1 moaA1 trpA trpA trpB trpB leuD3 leuD3 leuC3 leuC3 citE1 citE1 acnA acnA trg trg h16_A2713 h16_A2713 h16_A2758 h16_A2758 ltaA ltaA h16_A2792 h16_A2792 ribBA ribBA h16_A2858 h16_A2858 ubiD ubiD h16_A2900 h16_A2900 h16_A2909 h16_A2909 hemXD hemXD ppc ppc argH argH ldcC ldcC h16_A2946 h16_A2946 cbiB cbiB cobD cobD mcd mcd h16_A2987 h16_A2987 cbiX cbiX hutU1 hutU1 hutH hutH dfp dfp purB purB panD panD pyrF pyrF h16_A3165 h16_A3165 aroQ1 aroQ1 h16_A3245 h16_A3245 h16_A3311 h16_A3311 mltA mltA trpE trpE trpC trpC ubiX1 ubiX1 ubiD2 ubiD2 ubiX2 ubiX2 h16_A3374 h16_A3374 hisF hisF hisH hisH hisB hisB aroB aroB lysA2 lysA2 hemB hemB h16_A3550 h16_A3550 h16_A3581 h16_A3581 h16_A3593 h16_A3593 h16_A3598 h16_A3598 sdaA sdaA hemE hemE phhB phhB pepck pepck cynS cynS leuD4 leuD4 leuC4 leuC4 h16_B0064 h16_B0064 eutB eutB eutC eutC fumC fumC h16_B0127 h16_B0127 h16_B0131 h16_B0131 dapA2 dapA2 h16_B0217 h16_B0217 fbaB fbaB h16_B0280 h16_B0280 h16_B0321 h16_B0321 acmD acmD menG2 menG2 citE2 citE2 h16_B0354 h16_B0354 h16_B0359 h16_B0359 h16_B0365 h16_B0365 h16_B0389 h16_B0389 h16_B0402 h16_B0402 h16_B0405 h16_B0405 h16_B0415 h16_B0415 h16_B0419 h16_B0419 h16_B0426 h16_B0426 h16_B0447 h16_B0447 aroQ2 aroQ2 mhpD1 mhpD1 h16_B0549 h16_B0549 mhpE1 mhpE1 tdcB tdcB acnB acnB h16_B0590 h16_B0590 bpHI bpHI bphH bphH h16_B0615 h16_B0615 h16_B0620 h16_B0620 h16_B0657 h16_B0657 h16_B0679 h16_B0679 citE3 citE3 prpD2 prpD2 h16_B0698 h16_B0698 h16_B0706 h16_B0706 h16_B0756 h16_B0756 h16_B0810 h16_B0810 mhpD3 mhpD3 dapA3 dapA3 h16_B0915 h16_B0915 h16_B0965 h16_B0965 gabT gabT h16_B0988 h16_B0988 h16_B0998 h16_B0998 gloA2 gloA2 h16_B1174 h16_B1174 hpaI2 hpaI2 h16_B1211 h16_B1211 eda eda h16_B1223 h16_B1223 phnJ phnJ h16_B1338 h16_B1338 cyaA cyaA cbbA2 cbbA2 cbbS2 cbbS2 cbbL2 cbbL2 ipdC ipdC prpD3 prpD3 h16_B1439 h16_B1439 prpD4 prpD4 moaA2 moaA2 h16_B1504 h16_B1504 h16_B1519 h16_B1519 h16_B1607 h16_B1607 h16_B1608 h16_B1608 h16_B1662 h16_B1662 h16_B1669 h16_B1669 menB menB h16_B1716 h16_B1716 h16_B1741 h16_B1741 h16_B1759 h16_B1759 menG3 menG3 h16_B1823 h16_B1823 dapA4 dapA4 h16_B1902 h16_B1902 h16_B1914 h16_B1914 idgA idgA citE4 citE4 h16_B2160 h16_B2160 metY2 metY2 gloA5 gloA5 can2 can2 leuC5 leuC5 leuD5 leuD5 nirD nirD nirG nirG nirH nirH pcaB1 pcaB1 h16_B2377 h16_B2377 caa caa h16_B2446 h16_B2446 h16_B2447 h16_B2447 h16_B2455 h16_B2455 hmgL2 hmgL2 edd2 edd2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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h16_A0991Putative transglycosylase. (247 aa)
h16_A00722-Keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase. (282 aa)
h16_A0130Predicted integral membrane protein. (416 aa)
h16_A0142Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (277 aa)
canCarbonic anhydrase. (223 aa)
h16_A0186Hydroxymethylglutaryl-CoA lyase. (311 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (626 aa)
folBDihydroneopterin aldolase. (133 aa)
h16_A0377Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (292 aa)
h16_A0427Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (512 aa)
h16_A0431Pterin-4a-carbinolamine dehydratase. (114 aa)
gloA1Lactoylglutathione lyase (methylglyoxalase); Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (135 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (159 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (414 aa)
ebsCUncharacterized conserved protein; Function unknown; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (163 aa)
hpaI12,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (274 aa)
h16_A0674Adenylate cyclase, class 2. (179 aa)
hutU2Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (565 aa)
h16_A0703Putative transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (524 aa)
pheAPrephenate dehydratase, Chorismate mutase. (386 aa)
h16_A0869Protein of unknown function. (174 aa)
h16_A0870Protein of unknown function. (158 aa)
h16_A0873Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (132 aa)
h16_A1005Conserved hypothetical protein; Function unknown. (172 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (216 aa)
h16_A1101Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (371 aa)
nthEndonuclease III protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa)
edd1Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (631 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
dapA1Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
mvaBHydroxymethylglutaryl-CoA lyase. (314 aa)
leuC13-Isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuD13-Isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1167 aa)
h16_A1258D-Galactarate dehydratase. (386 aa)
h16_A1259D-Galactarate dehydratase. (96 aa)
h16_A1278ATP-dependent transcriptional regulator containing adenylate cyclase related domains. (1304 aa)
h16_A1296Hypothetical protein containing DUF35 domain. (132 aa)
metY1O-Acetylhomoserine sulfhydrylase. (436 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (381 aa)
h16_A1380Pyruvate-formate lyase-activating enzyme. (362 aa)
h16_A1410Enoyl-CoA hydratase. (567 aa)
h16_A1422Transcriptional regulator, LuxR-family containing alpha/beta hydrolase domain. (378 aa)
h16_A1457YgbB family protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (169 aa)
h16_A1479Hypothetical protein. (124 aa)
h16_A1526Enoyl-CoA hydratase/Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase. (693 aa)
h16_A1547Hydroxymethylglutaryl-CoA lyase. (319 aa)
leuC23-Isopropylmalate dehydratase large subunit. (473 aa)
leuD23-Isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (208 aa)
h16_A1560Ribulose-5-phosphate 4-epimerase or related epimerase or aldolase; Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2). (217 aa)
h16_A1568Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (331 aa)
h16_A1679Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (513 aa)
h16_A1716Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
mhpE24-Hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (347 aa)
rfbB2dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa)
h16_A1885Enoyl-CoA hydratase/carnithine racemase. (265 aa)
prpBMethylisocitric acid lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (302 aa)
acnMMethyl-cis-aconitic acid hydratase/Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (870 aa)
prpD12-Methylcitrate dehydratase. (484 aa)
ptpS6-Pyruvoyl tetrahydrobiopterin synthase protein. (158 aa)
h16_A1925Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (211 aa)
rspAL-Alanine-DL-glutamate epimerase, muconate lactonizing enzyme. (402 aa)
h16_A20443-Hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa)
h16_A2123Conserved hypothetical protein; Function unknown / General function predictiononly. (135 aa)
menCL-Alanine-DL-glutamate epimerase. (367 aa)
h16_A2141Conserved hypothetical protein. (620 aa)
h16_A2147Conserved hypothetical protein. (136 aa)
h16_A2151Putative acyl dehydratase. (290 aa)
iclAIsocitrate lyase. (526 aa)
iclBIsocitrate lyase. (431 aa)
menG1Demethylmenaquinone methyltransferase; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). (165 aa)
h16_A2250Hypothetical protein. (293 aa)
h16_A2258Enoyl-CoA hydratase/carnithine racemase; Enoyl-coa hydratase/isomerase family protein. (261 aa)
thrCThreonine synthase. (481 aa)
hmgL1Hydroxymethylglutaryl-CoA lyase. (322 aa)
pcaB23-Carboxy-cis,cis-muconate cyclo-isomerase. (448 aa)
abmCPutative enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (283 aa)
fumAFumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
moaA1Molybdopterin biosynthesis protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (374 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
leuD33-Isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa)
leuC33-Isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
citE1Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (326 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
trgPutative transglycosylase. (265 aa)
h16_A2713Conserved hypothetical protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (331 aa)
h16_A2758Altronate dehydratase. (522 aa)
ltaAThreonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (343 aa)
h16_A2792Uncharacterized protein involved in cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (268 aa)
ribBABifunctional riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (411 aa)
h16_A2858Hypothetical membrane associated protein. (352 aa)
ubiD3-Octaprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (509 aa)
h16_A2900GDP-D-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (346 aa)
h16_A2909dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (354 aa)
hemXDTwo domain protein: Uroporphyrinogen-III synthase/methylase. (707 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1012 aa)
argHArgininosuccinate lyase. (472 aa)
ldcCArginine/lysine/ornithine decarboxylase. (757 aa)
h16_A2946Acetyl-CoA carboxylase (Biotin carboxylase and carboxyl transferase domains). (1108 aa)
cbiBCobalamin biosynthesis protein (CbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (322 aa)
cobDCobalamin biosynthesis protein (CobD). (339 aa)
mcdMalonyl-CoA decarboxylase Malonyl-CoA decarboxylase. (485 aa)
h16_A2987Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
cbiXCobalamin biosynthesis CbiX protein. (130 aa)
hutU1Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (566 aa)
hutHHistidine ammonia-lyase (HAL). (525 aa)
dfpPhosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (416 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (458 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (120 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (272 aa)
h16_A3165Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (220 aa)
aroQ13-Dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (165 aa)
h16_A3245Lytic transglycosylase. (247 aa)
h16_A3311Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (274 aa)
mltAMembrane-bound lytic murein transglycosylase. (378 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (505 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa)
ubiX13-Polyprenyl-4-hydroxybenzoate decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (207 aa)
ubiD23-Octaprenyl-4-hydroxybenzoate carboxy-lyase; Belongs to the UbiD family. (480 aa)
ubiX23-Polyprenyl-4-hydroxybenzoate decarboxylase (flavoprotein); Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (198 aa)
h16_A3374Dehydratase maoC like domain. (158 aa)
hisFCyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
hisHGlutamine Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa)
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
aroB3-Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (368 aa)
lysA2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa)
hemBPorphobilinogen synthase; Belongs to the ALAD family. (330 aa)
h16_A3550Conserved hypothetical protein. (116 aa)
h16_A3581Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (256 aa)
h16_A3593Enoyl-CoA hydratase. (259 aa)
h16_A3598Glyoxylate carboligase; Belongs to the TPP enzyme family. (594 aa)
sdaAL-Serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (365 aa)
phhBPterin-4-alpha-carbinolamine dehydratase. (114 aa)
pepckPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (618 aa)
cynSCyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (147 aa)
leuD43-Isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (168 aa)
leuC43-Isopropylmalate dehydratase large subunit. (428 aa)
h16_B0064Conserved hypothetical protein. (453 aa)
eutBEthanolamine ammonia-lyase heavy chain. (460 aa)
eutCEthanolamine ammonia-lyase light chain; Belongs to the EutC family. (261 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
h16_B0127Glucarate dehydratase. (451 aa)
h16_B01315-Dehydro-4-deoxyglucarate dehydratase; Belongs to the DapA family. (304 aa)
dapA2Dihydrodipicolinate synthase; Belongs to the DapA family. (310 aa)
h16_B0217L-Alanine-DL-glutamate epimerase or related enzyme of enolase superfamily; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (391 aa)
fbaBFructose-bisphosphate aldolase class-I. (340 aa)
h16_B0280Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (619 aa)
h16_B0321Altronate dehydratase. (518 aa)
acmDAmidohydrolase, similiar to 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase. (326 aa)
menG2Demethylmenaquinone methyltransferase; Unknown EC_number=2.1.1.-. (227 aa)
citE2Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (331 aa)
h16_B0354Dehydrogenase with MaoC-like domain. (351 aa)
h16_B0359Acyl dehydratase. (166 aa)
h16_B0365Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
h16_B0389Enoyl-CoA hydratase. (261 aa)
h16_B0402Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (278 aa)
h16_B0405Conserved hypothetical protein. (132 aa)
h16_B0415Acyl dehydratase. (169 aa)
h16_B0419Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa)
h16_B0426Conserved hypothetical protein; Function unknown. (131 aa)
h16_B04472-Keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase. (301 aa)
aroQ23-Dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa)
mhpD12-Oxopent-4-enoate hydratase. (260 aa)
h16_B05494-Oxalocrotonate decarboxylase. (262 aa)
mhpE14-Hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (354 aa)
tdcBThreonine deaminase. (321 aa)
acnBAconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (863 aa)
h16_B0590Predicted nucleic-acid-binding protein containing a Zn-ribbon. (130 aa)
bpHI4-Hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (341 aa)
bphH2-Oxopent-4-enoate hydratase. (260 aa)
h16_B0615HMG-like protein. (317 aa)
h16_B0620L-Serine dehydratase, putative. (306 aa)
h16_B0657Enoyl-CoA hydratase/carnithine racemase. (295 aa)
h16_B0679Conserved hypothetical protein; Function unknown. (288 aa)
citE3Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (274 aa)
prpD22-Methylcitrate dehydratase. (460 aa)
h16_B0698Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
h16_B0706Acyl dehydratase. (153 aa)
h16_B0756Enoyl-CoA hydratase. (291 aa)
h16_B0810Amidohydrolase family protein. (320 aa)
mhpD32-Oxopent-4-enoate hydratase. (254 aa)
dapA3Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (322 aa)
h16_B0915Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
h16_B0965Probable D-galactarate dehydratase. (521 aa)
gabT4-Aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa)
h16_B0988Conserved hypothetical protein. (593 aa)
h16_B0998Conserved hypothetical protein. (172 aa)
gloA2Lactoylglutathione lyase. (140 aa)
h16_B1174Conserved hypothetical protein. (254 aa)
hpaI22,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (269 aa)
h16_B1211Amino acid aldolase or racemase. (422 aa)
eda2-Keto-3-deoxy-6-phosphogluconate aldolase. (214 aa)
h16_B12233; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (234 aa)
phnJUncharacterized enzyme of phosphonate metabolism; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family. (300 aa)
h16_B1338Hypothetical protein. (138 aa)
cyaAPutative AMP or GMP cyclase containing FHA domain. (301 aa)
cbbA2Fructose-1,6-/sedoheptulose-1,7-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (345 aa)
cbbS2Ribulose bisphosphate carboxylase small chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO small chain family. (139 aa)
cbbL2Ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity); Belongs to the RuBisCO large chain family. Type I subfamily. (486 aa)
ipdCIndole-3-pyruvate decarboxylase. (583 aa)
prpD32-Methylcitrate dehydratase. (444 aa)
h16_B1439Enoyl-CoA hydratase/carnithine racemase. (264 aa)
prpD42-Methylcitrate dehydratase. (461 aa)
moaA2Molybdopterin biosynthesis protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (381 aa)
h16_B1504Hypothetical protein. (99 aa)
h16_B1519ATP synthase beta subunit/transription termination factor rho. (1155 aa)
h16_B1607Tow domain protein: DNA-binding transcriptional activator of the SARP family. (1087 aa)
h16_B1608Predicted secreted hydrolase. (358 aa)
h16_B1662Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (571 aa)
h16_B16693-Oxoacyl-[acyl-carrier-protein] reductase. (162 aa)
menBNaphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (260 aa)
h16_B17162-Keto-4-pentenoatehydratase/2-oxohepta-3-ene-1- dioic acid hydratase (catechol pathway). (260 aa)
h16_B1741Enoyl-CoA hydratase. (286 aa)
h16_B1759Uncharacterized conserved protein; Function unknown; Belongs to the D-glutamate cyclase family. (270 aa)
menG3Demethylmenaquinone methyltransferase; Unknown EC_number=2.1.1.-. (226 aa)
h16_B1823Conserved hypothetical protein. (451 aa)
dapA4Dihydrodipicolinate synthase (DapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa)
h16_B1902Hypothetical protein. (117 aa)
h16_B1914Enoyl-CoA-hydratase/isomerase. (552 aa)
idgAIndigoidine synthase A like protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (336 aa)
citE4Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (273 aa)
h16_B2160Two domain protein: Adenylate cyclase, family protein. (1137 aa)
metY2O-Acetylhomoserine sulfhydrylase. (424 aa)
gloA5Lactoylglutathione lyase. (136 aa)
can2Beta-carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (235 aa)
leuC53-Isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
leuD53-Isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa)
nirDHeme d1 biosynthesis protein (NirD). (329 aa)
nirGHeme d1 biosynthesis protein (NirG). (154 aa)
nirHHeme d1 biosynthesis protein (NirH). (166 aa)
pcaB13-Carboxy-cis,cis-muconate cyclo-isomerase. (451 aa)
h16_B2377Conserved hypothetical protein; Function unknown. (175 aa)
caaPeriplasmic alpha-carbonic anhydrase. (249 aa)
h16_B24464-Hydroxybenzoate decarboxylase; Belongs to the UbiD family. (445 aa)
h16_B2447Phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (210 aa)
h16_B2455Ureidoglycolate hydrolase. (182 aa)
hmgL2Hydroxymethylglutaryl-CoA lyase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (315 aa)
edd2Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (618 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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