STRINGSTRING
h16_A3598 h16_A3598 h16_A0032 h16_A0032 speB speB mhpD2 mhpD2 ivd1 ivd1 h16_A0172 h16_A0172 h16_A0178 h16_A0178 h16_A0186 h16_A0186 h16_A0197 h16_A0197 aidB aidB h16_A0281 h16_A0281 h16_A0291 h16_A0291 h16_A0361 h16_A0361 acaD acaD h16_A0461 h16_A0461 h16_A0486 h16_A0486 h16_A0488 h16_A0488 dtd dtd hpaI1 hpaI1 h16_A0623 h16_A0623 hutU2 hutU2 dadA2 dadA2 h16_A0816 h16_A0816 dadA1 dadA1 maoB maoB h16_A0832 h16_A0832 h16_A0843 h16_A0843 lao1 lao1 pntAa1 pntAa1 lao2 lao2 h16_A0860 h16_A0860 h16_A1091 h16_A1091 hutG2 hutG2 edd1 edd1 mvaB mvaB h16_A1258 h16_A1258 h16_A1259 h16_A1259 h16_A1291 h16_A1291 hutG3 hutG3 h16_A1319 h16_A1319 h16_A1329 h16_A1329 gudB gudB h16_A1384 h16_A1384 bdxB bdxB h16_A1410 h16_A1410 dadA5 dadA5 h16_A1526 h16_A1526 h16_A1530 h16_A1530 h16_A1537 h16_A1537 h16_A1547 h16_A1547 h16_A1710 h16_A1710 h16_A1778 h16_A1778 h16_A1908 h16_A1908 tdh tdh rspA rspA h16_A1969 h16_A1969 ivd2 ivd2 ald ald h16_A2129 h16_A2129 menC menC h16_A2143 h16_A2143 h16_A2149 h16_A2149 h16_A2151 h16_A2151 odhB odhB hmgL1 hmgL1 h16_A2419 h16_A2419 abmD abmD h16_A2596 h16_A2596 h16_A2758 h16_A2758 h16_A2808 h16_A2808 h16_A2814 h16_A2814 kynU kynU tdo1 tdo1 gcdH gcdH hutI hutI hutU1 hutU1 hutH hutH dfp dfp paaI1 paaI1 paaL1 paaL1 h16_A3374 h16_A3374 h16_A3406 h16_A3406 paaA1 paaA1 paaB1 paaB1 paaC1 paaC1 paaD1 paaD1 gcvT1 gcvT1 gcvH gcvH gcvP gcvP putA putA hutG4 hutG4 phhA phhA h16_A3742 h16_A3742 h16_B0087 h16_B0087 h16_B0127 h16_B0127 h16_B0131 h16_B0131 h16_B0166 h16_B0166 h16_B0217 h16_B0217 h16_B0321 h16_B0321 menG2 menG2 h16_B0354 h16_B0354 h16_B0356 h16_B0356 h16_B0359 h16_B0359 h16_B0360 h16_B0360 h16_B0400 h16_B0400 h16_B0402 h16_B0402 h16_B0415 h16_B0415 h16_B0428 h16_B0428 h16_B0485 h16_B0485 h16_B0496 h16_B0496 h16_B0500 h16_B0500 dadA6 dadA6 h16_B0515 h16_B0515 mhpD1 mhpD1 h16_B0549 h16_B0549 h16_B0580 h16_B0580 bphH bphH bphD bphD h16_B0615 h16_B0615 h16_B0683 h16_B0683 h16_B0699 h16_B0699 h16_B0706 h16_B0706 h16_B0802 h16_B0802 h16_B0868 h16_B0868 h16_B0874 h16_B0874 h16_B0909 h16_B0909 h16_B0913 h16_B0913 h16_B0938 h16_B0938 h16_B0964 h16_B0964 h16_B0965 h16_B0965 h16_B0971 h16_B0971 h16_B0975 h16_B0975 h16_B1005 h16_B1005 h16_B1032 h16_B1032 h16_B1130 h16_B1130 hpaI2 hpaI2 h16_B1192 h16_B1192 h16_B1211 h16_B1211 h16_B1219 h16_B1219 h16_B1332 h16_B1332 paaL2 paaL2 paaD2 paaD2 paaC2 paaC2 paaB2 paaB2 paaA2 paaA2 h16_B1364 h16_B1364 h16_B1367 h16_B1367 h16_B1371 h16_B1371 tdo2 tdo2 h16_B1437 h16_B1437 h16_B1481 h16_B1481 h16_B1507 h16_B1507 h16_B1546 h16_B1546 h16_B1617 h16_B1617 h16_B1651 h16_B1651 fahA fahA hmgA hmgA h16_B1694 h16_B1694 h16_B1779 h16_B1779 h16_B1797 h16_B1797 menG3 menG3 h16_B1826 h16_B1826 h16_B1864 h16_B1864 boxB boxB h16_B1914 h16_B1914 h16_B1942 h16_B1942 h16_B2156 h16_B2156 dadA8 dadA8 pcaH1 pcaH1 h16_B2473 h16_B2473 hmgL2 hmgL2 h16_B2526 h16_B2526 h16_B2537 h16_B2537 h16_B2555 h16_B2555 h16_B2557 h16_B2557 edd2 edd2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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h16_A3598Glyoxylate carboligase; Belongs to the TPP enzyme family. (594 aa)
h16_A0032Prokaryotic protein of unknown function,predicted cytosolic protein. (310 aa)
speBAgmatinase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (316 aa)
mhpD22-Oxopent-4-enoate hydratase. (326 aa)
ivd1Isovaleryl-CoA dehydrogenase. (393 aa)
h16_A0172Acyl-CoA dehydrogenase, short-chain specific. (376 aa)
h16_A0178Dienelactone hydrolase or related enzyme. (280 aa)
h16_A0186Hydroxymethylglutaryl-CoA lyase. (311 aa)
h16_A0197Predicted hydrolase or acyltransferase. (299 aa)
aidBAcyl-CoA dehydrogenase, short-chain specific (probable AidB protein). (587 aa)
h16_A0281Diadenosine tetraphosphate (Ap4A) hydrolase. (145 aa)
h16_A0291Coenzyme F390 synthetase. (416 aa)
h16_A0361Putative fumarylacetoacetat hydroxylase. (233 aa)
acaDAcyl-CoA dehydrogenase. (595 aa)
h16_A0461Two domain protein: 3-hydroxyacyl-CoA dehydrogenase. (807 aa)
h16_A0486Putative phytanoyl-CoA dioxygenase. (265 aa)
h16_A0488Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (376 aa)
dtdD-Tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (153 aa)
hpaI12,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (274 aa)
h16_A0623Predicted metal-dependent hydrolase with the TIM-barrel fold. (569 aa)
hutU2Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (565 aa)
dadA2D-amino-acid dehydrogenase; Oxidative deamination of D-amino acids. (429 aa)
h16_A0816Acyl-CoA dehydrogenase. (594 aa)
dadA1D-amino-acid dehydrogenase; Oxidative deamination of D-amino acids. (434 aa)
maoBMonoamine oxidase (Flavin containing). (497 aa)
h16_A0832Putative phytanoyl-CoA dioxygenase. (277 aa)
h16_A0843Acyl-CoA dehydrogenase. (429 aa)
lao1L-Amino-acid oxidase. (472 aa)
pntAa1NAD(P) transhydrogenase subunit alpha 1. (372 aa)
lao2L-Amino-acid oxidase. (434 aa)
h16_A0860Putative phytanoyl-CoA dioxygenase. (278 aa)
h16_A1091FadE2-like Acyl-CoA dehydrogenase (ACAD). (420 aa)
hutG2N-Formylglutamate amidohydrolase. (295 aa)
edd1Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (631 aa)
mvaBHydroxymethylglutaryl-CoA lyase. (314 aa)
h16_A1258D-Galactarate dehydratase. (386 aa)
h16_A1259D-Galactarate dehydratase. (96 aa)
h16_A1291Isovaleryl-CoA dehydrogenase. (379 aa)
hutG3N-Formylglutamate amidohydrolase. (282 aa)
h16_A1319Predicted dehydrogenase. (368 aa)
h16_A1329Predicted thioesterase. (133 aa)
gudBNAD-specific glutamate dehydrogenase. (1618 aa)
h16_A1384Predicted thioesterase. (152 aa)
bdxBBenzoyl-CoA oxygenase component B. (474 aa)
h16_A1410Enoyl-CoA hydratase. (567 aa)
dadA5D-amino-acid dehydrogenase. (432 aa)
h16_A1526Enoyl-CoA hydratase/Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase. (693 aa)
h16_A1530Acyl-CoA dehydrogenase. (620 aa)
h16_A1537Putative peptidase, S33 family. (315 aa)
h16_A1547Hydroxymethylglutaryl-CoA lyase. (319 aa)
h16_A1710Hypothetical protein. (86 aa)
h16_A1778Predicted hydrolase or acyltransferase. (348 aa)
h16_A1908Conserved hypothetical protein; Function unknown. (396 aa)
tdhThreonine dehydrogenase (Zn dependent). (344 aa)
rspAL-Alanine-DL-glutamate epimerase, muconate lactonizing enzyme. (402 aa)
h16_A1969Conserved hypothetical protein; Function unknown. (284 aa)
ivd2Isovaleryl-CoA dehydrogenase. (393 aa)
aldAlanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa)
h16_A2129Predicted Zn-dependent hydrolase of the beta-lactamase fold; Metal-dependent hydrolase mm2300; Belongs to the UPF0173 family. (289 aa)
menCL-Alanine-DL-glutamate epimerase. (367 aa)
h16_A2143Acyl-CoA dehydrogenase, long-chain specific. (388 aa)
h16_A2149Acyl-CoA dehydrogenase, long-chain specific. (386 aa)
h16_A2151Putative acyl dehydratase. (290 aa)
odhBDihydrolipoamide S-succinyltransferase (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (416 aa)
hmgL1Hydroxymethylglutaryl-CoA lyase. (322 aa)
h16_A2419Two domain protein: PF04304 and PF03401. (679 aa)
abmDPutative acyl-CoA dehydrogenase. (389 aa)
h16_A2596Acyl-CoA dehydrogenase. (388 aa)
h16_A2758Altronate dehydratase. (522 aa)
h16_A2808BEC protein-catalyzes hydroxylation of indole to indoxyl / Acyl-CoA dehydrogenase. (417 aa)
h16_A2814Predicted metal-dependent hydrolase/Putative cyclase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (216 aa)
kynUL-Kynurenine hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (418 aa)
tdo1Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (294 aa)
gcdHGlutaryl-CoA dehydrogenase. (397 aa)
hutIImidazolonepropionase; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (417 aa)
hutU1Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (566 aa)
hutHHistidine ammonia-lyase (HAL). (525 aa)
dfpPhosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (416 aa)
paaI1Phenylacetic acid degradation protein. (150 aa)
paaL1Phenylacetate-CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (434 aa)
h16_A3374Dehydratase maoC like domain. (158 aa)
h16_A3406Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase. (118 aa)
paaA1Phenylacetic acid degradation protein A. (339 aa)
paaB1Phenylacetic acid degradation protein B. (95 aa)
paaC1Phenylacetic acid degradation protein C. (283 aa)
paaD1Phenylacetic acid degradation protein D. (186 aa)
gcvT1Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
gcvHGlycine cleavage system H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (976 aa)
putABifunctional proline dehydrogenase and proline oxidase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1321 aa)
hutG4N-Formylglutamate amidohydrolase. (290 aa)
phhAPhenylalanine 4-monooxygenase. (309 aa)
h16_A3742Lipase. (320 aa)
h16_B0087Acyl-CoA dehydrogenase. (598 aa)
h16_B0127Glucarate dehydratase. (451 aa)
h16_B01315-Dehydro-4-deoxyglucarate dehydratase; Belongs to the DapA family. (304 aa)
h16_B0166Potassium channel protein. (273 aa)
h16_B0217L-Alanine-DL-glutamate epimerase or related enzyme of enolase superfamily; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (391 aa)
h16_B0321Altronate dehydratase. (518 aa)
menG2Demethylmenaquinone methyltransferase; Unknown EC_number=2.1.1.-. (227 aa)
h16_B0354Dehydrogenase with MaoC-like domain. (351 aa)
h16_B0356Acyl-CoA dehydrogenase. (389 aa)
h16_B0359Acyl dehydratase. (166 aa)
h16_B0360Acyl-CoA dehydrogenase. (388 aa)
h16_B0400Medium-chain acyl-CoA dehydrogenase. (387 aa)
h16_B0402Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (278 aa)
h16_B0415Acyl dehydratase. (169 aa)
h16_B0428Putative fumarylpyruvate hydrolase. (237 aa)
h16_B0485Acyl-CoA dehydrogenase, short-chain specific. (400 aa)
h16_B04964-Hydroxyphenylacetate-3-hydroxylase. (494 aa)
h16_B0500Conserved hypothetical protein. (229 aa)
dadA6D-amino-acid dehydrogenase. (422 aa)
h16_B0515Predicted metal-dependent hydrolase of the TIM-barrel fold. (284 aa)
mhpD12-Oxopent-4-enoate hydratase. (260 aa)
h16_B05494-Oxalocrotonate decarboxylase. (262 aa)
h16_B0580Acyl-CoA dehydrogenase. (385 aa)
bphH2-Oxopent-4-enoate hydratase. (260 aa)
bphD2,6-dioxo-6-phenylhexa-3-enoate hydrolase. (290 aa)
h16_B0615HMG-like protein. (317 aa)
h16_B0683Acyl-CoA dehydrogenase. (389 aa)
h16_B0699Acyl-CoA dehydrogenase, long-chain specific. (378 aa)
h16_B0706Acyl dehydratase. (153 aa)
h16_B0802Pyridine nucleotide-disulphide oxidoreductase. (426 aa)
h16_B0868Metal-dependent hydrolase. (558 aa)
h16_B0874Fumarylpyruvate hydrolase. (232 aa)
h16_B0909Acyl-CoA dehydrogenase. (394 aa)
h16_B0913Acyl-CoA dehydrogenase. (388 aa)
h16_B0938Acyl-CoA dehydrogenase. (392 aa)
h16_B0964Conserved hypothetical protein. (351 aa)
h16_B0965Probable D-galactarate dehydratase. (521 aa)
h16_B0971FAD-dependent monooxygenase. (552 aa)
h16_B0975Acyl-CoA dehydrogenase. (379 aa)
h16_B1005Conserved hypothetical protein; Function unknown. (352 aa)
h16_B1032Conserved hypothetical protein. (353 aa)
h16_B1130FAD dependent oxidoreductase. (388 aa)
hpaI22,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (269 aa)
h16_B1192Acyl-CoA dehydrogenase. (377 aa)
h16_B1211Amino acid aldolase or racemase. (422 aa)
h16_B1219Metal-dependent amidohydrolase. (316 aa)
h16_B1332Acyl-CoA dehydrogenase. (521 aa)
paaL2Phenylacetate-CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (449 aa)
paaD2Phenylacetic acid degradation protein D. (171 aa)
paaC2Phenylacetic acid degradation protein C. (251 aa)
paaB2Phenylacetic acid degradation protein B. (93 aa)
paaA2Phenylacetic acid degradation protein A. (328 aa)
h16_B1364Transcriptional regulator, PAAX-family. (312 aa)
h16_B1367Acyl-CoA dehydrogenase. (388 aa)
h16_B1371Acyl-CoA dehydrogenase, short-chain specific. (385 aa)
tdo2Tryptophan 2,3-dioxygenase. (298 aa)
h16_B1437Hydrolase or acyltransferase (alpha/beta hydrolase superfamily). (282 aa)
h16_B1481Acyl-CoA dehydrogenase. (405 aa)
h16_B1507Putative peptidase, M38 family. (412 aa)
h16_B15462-Polyprenyl-6-methoxyphenol hydroxylase or related FAD-dependent oxidoreductase. (580 aa)
h16_B1617Conserved hypothetical protein; Function unknown. (352 aa)
h16_B1651Uncharacterized conserved protein; Function unknown. (293 aa)
fahAFumarylacetoacetase hydrolase. (420 aa)
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (439 aa)
h16_B1694Acyl-CoA Dehydrogenase. (383 aa)
h16_B1779Putative peptidase, S33 family. (350 aa)
h16_B1797Conserved hypothetical protein. (294 aa)
menG3Demethylmenaquinone methyltransferase; Unknown EC_number=2.1.1.-. (226 aa)
h16_B1826Acyl-CoA dehydrogenase. (397 aa)
h16_B1864Putative acyl-CoA dehydrogenase, putative desulfurization enzyme. (403 aa)
boxBBenzoyl-CoA dioxygenase B; Unknown EC_number=1.13.14.-. (475 aa)
h16_B1914Enoyl-CoA-hydratase/isomerase. (552 aa)
h16_B1942Conserved hypothetical protein; General function prediction only. (646 aa)
h16_B2156Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
dadA8D-amino-acid dehydrogenase. (394 aa)
pcaH1Protocatechuate 3,4-dioxygenase beta chain. (233 aa)
h16_B2473Exoenzymes regulatory protein aepA precursor. (552 aa)
hmgL2Hydroxymethylglutaryl-CoA lyase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (315 aa)
h16_B2526Conserved hypothetical protein; Function unknown. (352 aa)
h16_B2537Conserved hypothetical protein; Function unknown; Belongs to the SlyX family. (67 aa)
h16_B2555Acyl-CoA dehydrogenase, short-chain specific. (385 aa)
h16_B25573-(3-hydroxy-phenyl) propionate hydroxylase. (560 aa)
edd2Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (618 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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