STRINGSTRING
h16_A2709 h16_A2709 h16_A2734 h16_A2734 polA polA h16_A2915 h16_A2915 h16_A2929 h16_A2929 pilU pilU h16_A3152 h16_A3152 h16_A3163 h16_A3163 h16_A3168 h16_A3168 h16_A3206 h16_A3206 h16_A3214 h16_A3214 h16_A3229 h16_A3229 stbB1 stbB1 h16_A3546 h16_A3546 h16_A3579 h16_A3579 h16_A3583 h16_A3583 h16_A3746 h16_A3746 h16_B0156 h16_B0156 sbcD sbcD sbcC sbcC h16_B0576 h16_B0576 h16_B0631 h16_B0631 stbB2 stbB2 h16_B0768 h16_B0768 phnA phnA h16_B0966 h16_B0966 h16_B0978 h16_B0978 ruvC ruvC h16_A0526 h16_A0526 xseA xseA h16_A0654 h16_A0654 h16_A0752 h16_A0752 dnaE1 dnaE1 cafA1 cafA1 h16_A0949 h16_A0949 h16_A0952 h16_A0952 h16_A1105 h16_A1105 uvrB uvrB dnaN dnaN h16_A0006 h16_A0006 h16_A0008 h16_A0008 h16_A0014 h16_A0014 h16_A0023 h16_A0023 h16_A0057 h16_A0057 h16_A0223 h16_A0223 uvrA1 uvrA1 h16_A0456 h16_A0456 cJ cJ h16_A1175 h16_A1175 h16_A1368 h16_A1368 h16_A1573 h16_A1573 h16_A1593 h16_A1593 h16_A1654 h16_A1654 h16_A1707 h16_A1707 h16_A2022 h16_A2022 rnhB rnhB h16_A2124 h16_A2124 vacB vacB h16_A2371 h16_A2371 h16_A2372 h16_A2372 h16_B2474 h16_B2474 h16_B2432 h16_B2432 h16_B2389 h16_B2389 h16_B2374 h16_B2374 h16_B2352 h16_B2352 h16_B2261 h16_B2261 h16_B2006 h16_B2006 h16_B1948 h16_B1948 h16_B1861 h16_B1861 uvrA2 uvrA2 elsH elsH h16_B1204 h16_B1204 h16_B1168 h16_B1168 h16_B1120 h16_B1120 dnaE2 dnaE2 cB cB addB addB h16_A2430 h16_A2430 rnhA rnhA dnaQ dnaQ h16_A2475 h16_A2475 h16_A2480 h16_A2480 h16_A2491 h16_A2491 uvrC uvrC h16_A2555 h16_A2555 cafA2 cafA2 h16_A2675 h16_A2675
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
h16_A2709Oligoribonuclease (3'->5' exoribonuclease); 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (208 aa)
h16_A2734Exonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (102 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (938 aa)
h16_A2915Predicted endonuclease involved in recombination; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (141 aa)
h16_A2929Predicted nucleic acid-binding protein,containsPIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (138 aa)
pilUType IV pilus twitching motility protein PilU. (379 aa)
h16_A3152Guanyl-specific ribonuclease. (123 aa)
h16_A3163Transcriptional regulator, Exoribonuclease II-family. (700 aa)
h16_A3168Conserved hypothetical protein. (229 aa)
h16_A3206GP29 like protein (of Bacteriophage phiE125). (174 aa)
h16_A3214Hypothetical protein. (184 aa)
h16_A3229Conserved hypothetical protein. (265 aa)
stbB1Plasmid stability protein StbB. (140 aa)
h16_A3546Uncharacterized conserved protein; Function unknown. (417 aa)
h16_A3579Predicted endonuclease distantly to archaeal holliday junction resolvase; Belongs to the UPF0102 family. (131 aa)
h16_A3583Conserved hypothetical protein. (213 aa)
h16_A3746Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (184 aa)
h16_B0156Conserved hypothetical protein; Belongs to the UPF0213 family. (92 aa)
sbcDDNA repair exonuclease, SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (395 aa)
sbcCDNA repair exonuclease, SbcC. (1020 aa)
h16_B0576Nucleic acid-binding protein of Vap family; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (132 aa)
h16_B0631Conserved hypothetical protein. (321 aa)
stbB2Plasmid stability protein StbB; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (142 aa)
h16_B0768Exconuclease. (528 aa)
phnAPhosphonoacetate hydrolase. (406 aa)
h16_B0966Conserved hypothetical protein; Function unknown. (74 aa)
h16_B0978Metal-dependent hydrolase of the beta-lactamase superfamily. (346 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (181 aa)
h16_A0526Diacylglycerol kinase; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (248 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (476 aa)
h16_A0654Hemolysin-coregulated protein. (161 aa)
h16_A0752Uncharacterized protein conserved in bacteria. (224 aa)
dnaE1DNA polymerase III alpha subunit. (1173 aa)
cafA1Ribonuclease G and E. (488 aa)
h16_A0949Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (239 aa)
h16_A0952Stress-induced protein. (311 aa)
h16_A1105Predicted nucleic acid-binding protein containing PIN domain. (153 aa)
uvrBExcinuclease ABC, helicase subunit (B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits [...] (694 aa)
dnaNDNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa)
h16_A0006Type I restriction-modification system restriction subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1106 aa)
h16_A00085-Methylcytosine-specific restriction enzyme B. (792 aa)
h16_A0014Predicted restriction endonuclease. (371 aa)
h16_A0023Conserved hypothetical protein. (186 aa)
h16_A0057Conserved hypothetical protein. (399 aa)
h16_A0223Exodeoxyribonuclease III. (258 aa)
uvrA1Excinuclease ABC, ATPase subunit (A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (953 aa)
h16_A0456Metal-dependent hydrolase. (260 aa)
cJSingle-stranded-DNA-specific exonuclease RecJ. (565 aa)
h16_A1175Mg-dependent DNase. (279 aa)
h16_A1368Exonuclease III. (276 aa)
h16_A1573Mg-dependent DNase. (264 aa)
h16_A1593Lysophosphatidic acid acyltransferase LPAAT related acyltransferase. (300 aa)
h16_A1654Hypothetical membrane spanning protein; 4 TMHs. (660 aa)
h16_A1707Conserved hypothetical protein. (113 aa)
h16_A2022Putative RNA Modifying Enzyme. (452 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (238 aa)
h16_A2124Hypothetical protein. (61 aa)
vacBExoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (909 aa)
h16_A2371Metal-dependent hydrolase. (284 aa)
h16_A2372Predicted 3'-5' exonuclease related to the exonuclease domain of PolB. (278 aa)
h16_B2474Conserved hypothetical protein; Function unknown. (96 aa)
h16_B2432Conserved hypothetical protein. (174 aa)
h16_B2389Putative exonuclease. (220 aa)
h16_B2374Conserved hypothetical protein. (60 aa)
h16_B2352ATP-dependent DNA ligase. (910 aa)
h16_B2261Hypothetical protein. (145 aa)
h16_B2006Predicted nucleic acid-binding protein,containsPIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (136 aa)
h16_B1948Phosphonoacetate hydrolase. (420 aa)
h16_B1861PemK-like protein DNA binding protein; Toxic component of a type II toxin-antitoxin (TA) system. (119 aa)
uvrA2Excinuclease ABC, ATPase subunit (A2); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1953 aa)
elsHMetal-dependent hydrolase. (243 aa)
h16_B1204Conserved hypothetical protein. (126 aa)
h16_B1168Conserved hypothetical protein. (667 aa)
h16_B1120Extracellular nuclease. (600 aa)
dnaE2DNA polymerase III alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1136 aa)
cBATP-dependent exoDNAse (exonuclease V) beta subunit; Belongs to the helicase family. UvrD subfamily. (1200 aa)
addBTwo domain protein: Inactivated superfamily I helicase and RecB family exonuclease. (955 aa)
h16_A2430Hypothetical membrane associated protein,contains exonuclease domain. (247 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (145 aa)
dnaQDNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (246 aa)
h16_A2475Hypothetical protein. (121 aa)
h16_A2480MobA/MobL family protein. (457 aa)
h16_A2491Conserved hypothetical protein. (403 aa)
uvrCExcinuclease ABC, nuclease subunit (C); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (681 aa)
h16_A2555dsRNA-specific ribonuclease; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (256 aa)
cafA2Ribonuclease G and E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1024 aa)
h16_A2675Conserved hypothetical protein; Function unknown. (118 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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